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Functional Organization of the Skin as an Immune Response Organ: Skin, Immune Response, and Useful Immunohistochemistry

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Cutaneous Hematopathology

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Abstract

This chapter describes properties of the skin which endow it with the ability to function as an immune response organ. Cellular constituents of the innate (nonspecific) and secondary (specific) immune responses in the skin are discussed. Lymphocyte trafficking which enables the immune response by interaction of lymphocyte surface molecules (addressins) and their cognate receptors in the skin and lymph node is presented. Helper T-cell subsets, the cytokines they produce, and cytokine receptors are outlined and illustrated. The significance of cytokines as therapeutic targets for cutaneous lymphomas and inflammatory diseases is emphasized. Topographical localization and interaction of specific cellular components of the immune response in inflammatory and neoplastic disorders are outlined. Finally, a table summarizing antibodies currently in use for the diagnosis and classification of cutaneous lymphomas and leukemias is included.

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Authors and Affiliations

  1. Department of Dermatology, Roger Williams Medical Center, Boston University School of Medicine, 50 Maude Street, Elmhurst Bldg., Providence, RI, 02908, USA

    Marshall E. Kadin MD

  2. Department of Hematopathology and Cutaneous Lymphoma, IHCFLOW Diagnostic Laboratory, Lutz, FL, USA

    Hernani D. Cualing MD

Authors
  1. Marshall E. Kadin MD
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  2. Hernani D. Cualing MD
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Correspondence to Marshall E. Kadin MD .

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Editors and Affiliations

  1. Department of Hematopathology, IHCFLOW Diagnostic Laboratory, Lutz, Florida, USA

    Hernani D. Cualing

  2. Department of Dermatology, Boston University School of Medicine, Roger Williams Medical Center, Providence, Rhode Island, USA

    Marshall E. Kadin

  3. Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    Mai P. Hoang

  4. Pensacola and Atlanta Dermpath Diagnostics, University of South Florida College of Medicine, Tampa, Florida, USA

    Michael B. Morgan

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Kadin, M.E., Cualing, H.D. (2014). Functional Organization of the Skin as an Immune Response Organ: Skin, Immune Response, and Useful Immunohistochemistry. In: Cualing, H., Kadin, M., Hoang, M., Morgan, M. (eds) Cutaneous Hematopathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0950-6_2

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  • DOI: https://doi.org/10.1007/978-1-4939-0950-6_2

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