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Cav3 Calcium Channel Interactions with Potassium Channels

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Voltage-Gated Calcium Channels

Abstract

The influence of potassium channels on cell activity is markedly enhanced by exhibiting the low voltage for activation, fast activation, and fast inactivation that characterize an A-type channel profile. Previous work had identified only a subset of members of the voltage-gated Kv1, Kv3, and Kv4 families in which alpha subunits are able to exhibit A-type biophysical properties. Recent work has shown that Cav3 channels closely associate with different potassium channels to impart their biophysical and kinetic properties and effectively create three new forms of A-type potassium channel. Cav3-K channel interactions identified to date include Cav3-Kv4, Cav3-IK, and Cav3-BK that enable novel aspects of synaptic processing and spike discharge in cerebellar granule, stellate, Purkinje, and medial vestibular neurons. This chapter will highlight data obtained in each of these cell classes of how Cav3 associations with different potassium channels extend the number of channels capable of exhibiting an A-type phenotype to control cell activity.

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Acknowledgments

We gratefully acknowledge J. Forden, L. Chen, and M Kruskic for their technical assistance in these studies and numerous trainees in the Turner lab who contributed to this work. These studies were supported by operating grants from the Canadian Institutes for Health Research.

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Authors and Affiliations

  1. Hotchkiss Brain Institute, Alberta Children’s Hospital Research Institute, Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

    Ray W. Turner

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  1. Ray W. Turner
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Correspondence to Ray W. Turner .

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Editors and Affiliations

  1. Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

    Gerald Werner Zamponi

  2. Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic

    Norbert Weiss

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Turner, R.W. (2022). Cav3 Calcium Channel Interactions with Potassium Channels. In: Zamponi, G.W., Weiss, N. (eds) Voltage-Gated Calcium Channels . Springer, Cham. https://doi.org/10.1007/978-3-031-08881-0_10

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