Vincent Racaniello’s Post

Immune 80: Intranasal neomycin; sex hormones and skin immunity; and maternal diet and infant microbiomes 〰️ Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health. Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker. 📺 https://bit.ly/4aHBcEl

TWiN 51: Sensory processing dysfunction in autism spectrum disorders 〰️ TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison. 📺 https://bit.ly/4bQRQ61

Immune 79: Spa therapy for the immune system 〰️ Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker. 📺 https://bit.ly/3VimKhq

TWiM 310: Starvation vs. Dehydration – who loses, who wins? 💦 TWiM explores the plasticity of the adult human small intestinal stoma microbiota, and survival and rapid resuscitation that permit limited productivity in desert microbial communities. Hosts: Michael Schmidt, Michele Swanson, and Petra Levin. 📺 https://bit.ly/3Vgw85b

TWiV 1117: Pol dances with the RNA that brought it 〰️ TWiV discusses presence of infectious avian H5N1 influenza virus in raw milk from infected dairy cows, dynamics of measles immunity from birth and following vaccination, and a mechanism for cis-preferential reverse transcription revealed by deep mutational scanning of hepatitis B virus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker. 📺 https://bit.ly/3wV5JRd

TWiV 1116: Clinical update with Dr. Daniel Griffin 🩺 In his weekly clinical update, Dr. Griffin delves into highly pathogenic H5N1 biology including its circulation in New York City, being able to infect cells within mammary glands and why testing is not supported before reviewing the recent statistics on SARS-CoV-2 infection, how vaccination reduced deaths and hospitalizations associated with COVID-19 and how to take off PPE to reduce virus transmission, discussing the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database and the global phase 3 trail of a novel antiviral, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, reminisces about when available monoclonal antibody therapies were effective, and discusses muscle training/exercise for treatment of PASC/long COVID and the use of RNase for its treatment. For more information about long COVID-19 listen to TWiV 1088. 📺 https://bit.ly/4dSnYYd

TWiV 1115: Calling the CoPs on flu 😷 TWiV reviews results of a phase 3 trial of a self-amplifying mRNA COVID-19 vaccine, and the finding that baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology. Hosts: Dickson Despommier, Alan Dove, and Brianne Barker. 📺 https://bit.ly/3K6VLiz

TWiV 1114: Clinical update with Dr. Daniel Griffin 🩺 Dr. Griffin delves into discussing drinking “raw” milk possessing H5N1 influenza virus, if the virus can reproduce in the human gut, and the meaning of finding viral RNA in wastewater samples before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, withdrawal of AstraZeneca’s SARS-CoV-2 vaccine from the European market, discusses the emergency use application of a pre-exposure prophylactic, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of colchicine for the management of COVID-19, compares and provides information for the enrollment into the NIH clinical trials of long COVID and its effects on sleep, exercise intolerance and the cognitive profile in multiple sclerosis and post-COVID, exercise intolerance and post-exertional malaise. For more information about cow and milk infection by H5N1 listen to the discussion with Richard Webby on TWiV 1113 and for long COVID-19 listen to TWiV 1088. Dr. Griffin also provides a list of apps for monitoring one’s health including brain health. 📺 https://bit.ly/3WOn7lo

TWiP 235: The case of the regurgitated wriggler 🪱 TWiP solves the case of a man in his 50s reporting months of abdominal discomfort, who takes mebendazole and sometime afterwards vomits a worm into the sink. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula. 📺 https://bit.ly/4bLsi9T

Beyond the Noise #39: Connecticut stands up for its children 💉 Connecticut recently bucked the national trend by eliminating a religious exemption to vaccination. This video is based on two of Dr. Offit’s substack posts, “Connecticut stands up for its children.” 📺 https://bit.ly/3QMKNCB