Sunday, March 1, 2009 - Biophysical Society

7:30 AM–8:30 AM Postdoctoral Breakfast 2 5 3 

7:30 AM–10:00 PM Family Room 255 

7:30 AM–5:00 PM Registration/Exhibitor Registration/Information N o r t h 

8:00 AM–5:30 PM Career Center Hall 

8:00 AM–6:00 PM Child Care Westin, 

8:00 AM–10:00 PM Poster Viewing Hall 

8:15 AM–10:15 AM 

8:15 AM–10:15 AM 

8:15 AM–10:15 AM 

8:15 AM–10:15 AM 

8:15 AM–10:15 AM 

8:15 AM–10:15 AM 

8:15 AM–10:15 AM 

8:15 AM–10:15 AM 

Sunday, March 1, 2009, Boston, Massachusetts 

Symposium 1 Ballroom 

East 

Protein Modularity and Flexibility in Signal Transduction 

David Eliezer, Weill Medical College of Cornell University, Co-Chair 

Richard Kriwacki, St. Jude Children’s Research Hospital, Co-Chair 

Mechanisms of Biological Regulation by Highly Dynamic Protein Complexes. Julie Forman-Kay 

The Modular Logic of Cell Signaling Systems. Wendell Lim 

Allosteric Effects and Conformational Selection in Signaling: The Ubiquitin E3 Ligases. Ruth Nussinov 

Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein. Mike Rosen 

Symposium 2 Ballroom 

West 

Many Ways to Regulate a Molecular Motor 

Samantha Harris, University of California, Davis, Chair 

Force-dependent Regulation of Myosin-I. Michael Ostap 

Heads to Tails: How Some Myosins Regulate Their Activity. James Sellers 

The Ups and Downs of Smooth Muscle Myosin Regulation. Kenneth Taylor 

Platform A 1 0 2 

A/B 

Platform B 1 0 4 

A/B 

Platform C 1 5 1 

A/B 

Platform D 1 5 3 

A/B 

Platform E 2 5 2 

A/B 

Platform F 2 5 4 

A/B 

9:00 AM–10:30 AM CPOW Committee Meeting 251 

10:00 AM–5:00 PM Exhibits Hall A 

10:15 AM–11:00 AM Coffee Break Exhibit Hall Lounge 

10:30 AM–1:00 PM Undergraduate Student Symposium 153 C 

10:45 AM–12:45 PM 

Sunday, March 1, 2009 

Daily Program Summary 

All rooms in the Boston Convention and Exhibition Center unless noted otherwise. 

Symposium 3 Ballroom East 

The Biophysics of HIV 

David Millar, Scripps Research Institute, Chair 

Mechanisms of Nucleic Acid Chaperones Involved in Retroviral Replication. Karin Musier-Forsyth 

Assembly of Ribonucleoproteins Involved in Viral RNA Trafficking. David Millar 

Insights into the Mechanisms of Genome Selection and Membrane Targeting by the HIV-1 Gag Protein. Michael Summers 

The Biochemistry of HIV Budding. Wesley Sundquist 

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10:45 AM–12:45 PM 

10:45 AM–12:45 PM 

10:45 AM–12:45 PM 

10:45 AM–12:45 PM 

10:45 AM–12:45 PM 

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Symposium 4 Ballroom West 

Systems Biology 

Ravi Iyengar, Mount Sinai School of Medicine, Chair 

Designing Biological Systems. Pamela Silver 

Design Principles of Biological Circuits. Uri Alon 

Nature, Nurture, or Just Blind Chance: Stochastic Gene Expression and Its Consequences. 

Alexander van Oudenaarden, 

Functional Organization of Mammalian Cells. Ravi Iyengar 

Minisymposium 1 102 A/B 

Virus Mechanics: Material Properties and Assembly 

William Gelbart, University of California, Los Angeles and Christoph Schmidt, Georg-August-Universität, Gottingen, Germany, 

Co-Chairs. 

Biophysical Studies of Virus Particles and their Maturation: Insights into Elegantly Programmed Nano-machines. 

Jack Johnson 

Modeling the Size and Structure of RNA: Viral vs. Non-viral Sequences. 

Avinoam Ben-Shaul 

Structural Mechanics of Viral Shells: Stretching the Limits of Continuum Models. 

William Klug 

The Influenza Virus Mechanical Properties Are Dominated By Its Lipid Envelope. 

Frederic Eghiaian 

Single-Molecule Studies of Viral DNA Packaging with Optical Tweezers: Molecular Motor Function and DNA Confinement. 

Douglas Smith 

Response of Viral Shells under Nano-Indentation. 

Christoph Schmidt 

Platform G 104 A/B 

Imaging & Optical Microscopy 

Platform H 151 A/B 

Membrane Physical Chemistry I 

Platform I 153 A/B 

DNA, RNA Structure & Conformation 

10:45 AM–12:45 PM 

Platform J 

Calcium Fluxes, Sparks, & Waves 

252 A/B 

10:45 AM–12:45 PM 

Platform K 

Ion Channels, Other 

254 A/B 

11:00 AM–12:00 PM International Relations Committee Meeting 105 

11:00 AM–12:30 PM 

Exhibitor Presentation 

Veeco Instruments 

103 

12:00 PM–1:00 PM International Travel Awardee Luncheon 105 

12:00 PM–2:00 PM Career Roundtable Luncheon 253 A/B 

12:00 PM–2:00 PM Public Affairs Committee Meeting 152 

1:00 PM–2:30 PM 

Early Careers Committee Panel 253 C 

Negotiating the Transition 

Differences between Academia and Industry 

1:00 PM–3:00 PM Graduate Institution Fair Hall A 

1:45 PM–3:00 PM Snack Break Exhibit Hall Lounge 

1:45 PM–3:45 PM Poster Presentations Hall A 

2:30 PM–4:30 PM 

Public Affairs Committee Panel 153 C 

Science Policy in the Obama Administration 

3:30 PM–4:30 PM Early Careers Committee Meeting 152 

4:00 PM–6:00 PM 

Symposium 5 Ballroom East 

How Proteins Move on DNA 

Smita Patel, UMDNJ RWJ Medical School, Chair 

High-Resolution Optical Trap Measurements of a Ringed DNA Translocase. Yann Chemla 

High Throughput Assays for Visualizing Individual Protein-DNA Interactions. Eric Greene 

Two Motors Move on DNA in a Cooperative Manner to Catalyze DNA Replication. Smita Patel 

Translocation and Unwinding by DnaB. Omar A. Saleh 

Biophysical Society 53 rd Annual Meeting

(Continued from previous page.) 

4:00 PM–6:00 PM 

4:00 PM–6:00 PM 

4:00 PM–6:00 PM 

4:00 PM–6:00 PM 

4:00 PM–6:00 PM 

4:00 PM–6:00 PM 


Symposium 6 Ballroom West 

Store-operated Calcium Channels in the Molecular Age 

Richard Lewis, Stanford University School of Medicine, Chair 

STIMulating Calcium Entry at ER-Plasma Membrane Junctions. Jen Liou 

Store-operated Calcium Entry in Lymphocyte Activation and Disease. Stefan Feske 

Structural and Mechanistic Insights into STIM1-mediated Initiation of Store-operated Calcium Entry. Mitsu Ikura 

A Molecular Mechanism for CRAC Channel Activation. Richard Lewis 

Platform L 102 A/B 

Membrane Protein Structure 

Platform M 104 A/B 

Cell & Bacterial Mechanics Motility 

Platform N 151 A/B 

Membrane Dynamics & Bilayer Probes 

Platform O 153 A/B 

Phototransduction: Signaling Events Downstream of Photon Absorption 

Platform P 252 A/B 

Muscle: Molecular Mechanics and Structure 

6:00 PM–7:00 PM Biophysical Society of Canada Mixer 253 A/B 

6:00 PM–8:00 PM SRAA Poster Competition Hall A 

7:30 PM–9:30 PM 

7:30 PM–9:30 PM 

7:30 PM–9:30 PM 

Workshop 1 Ballroom East 

Advanced Single Molecule Fluorescence Techniques in Vitro and in Vivo 

Jeff Gelles, Brandeis University, Chair 

Single-Molecule Analysis of Transcription. Richard Ebright 

In Vitro and in Vivo; Kinesin and Myosin Moving One (or a Few) at A Time. Paul Selvin 

In Vivo Super-Resolution Microscopy by Structured Illumination. Mats Gustafsson 

Advanced Fluorescence Microscopy of Single, Living Cells: Using Optical Proteomics to Study Native Biochemistry One Molecule 

at A Time. Mark Leake 

Elucidating Regulatory Mechanisms in Complex Systems by Single-Molecule Light Microscopy. Jeff Gelles 

Workshop 2 Ballroom West 

Channelopathies of Nerve and Muscle 

Stephen Cannon, University of Texas Southwestern Medical Center at Dallas, Chair 

Mechanistic Insights on Channelopathies of Brain and Skeletal Muscle. Stephen Cannon 

Neuronal Calcium Channels and Migraine. Daniela Pietrobon 

Presenilins Function as ER Calcium Leak Channels: Implications for AD. Ilya Bezprozvanny 

Sodium Channel Gating Pore Current in Periodic Paralysis. William Catterall 

Gating Pore Currents in NaV1.4 Channels: Insights into Voltage-Sensor Structure and Pathological Implications for Human 

Periodic Paralysis. Arie Struyk 

Workshop 3 153 A/B 

Enzymes in Energy Metabolism 

Michael Radermacher, University of Vermont, Chair 

Enzymes in Energy Metabolism, Introduction. Michael Radermacher 

Organization and Structural Features of Phosphofructokinase and Other Glycolytic Enzymes to Meet Their Role in Energy 

Metabolism. Juan J. Aragón 

How Mitochondrial Structure Can Affect Energy Metabolism: Insights from Electron Tomography. Carmen Mannella 

Molecular Architecture of Pyruvate Dehydrogenase Complexes. Jacqueline Milne 

Electroneutral and Electrogenic Catalysis by Diheme-containing Succinate: Quinone Oxidoreductases. C. Roy Lancaster 

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Sunday, March 1 

7:30 AM–8:30 AM, ROOM 253 A/B 

POSTDOCTORAL BREAKFAST 

Supported by the Burroughs Wellcome Fund. 

The Early Careers Committee hosts this annual breakfast. Discussion will focus 

on the career development activities of the Early Careers Committee, plans for 

future events, and other issues facing Early Career scientists. Space is limited to 

the first 100 attendees. 

7:30 AM–10:00 PM, ROOM 255 

FAMILY ROOM 

7:30 AM–5:00 PM, NORTH LOBBY 

REGISTRATION/INFORMATION 

8:00 AM–5:30 PM, HALL A 

CAREER CENTER 

8:00 AM–6:00 PM, WESTIN, OTIS 

CHILD CARE 

8:00 AM–10:00 PM, HALL A 

POSTER VIEWING 

8:15 AM–10:15 AM, BALLROOM EAST 

SYMPOSIUM 1 

Protein Modularity and Flexibility in 

Signal Transduction 

Co-Chairs: David Eliezer, Weill Medical College of Cornell University 

Richard Kriwacki, St. Jude Children’s Research Hospital 

12-SYMP 8:15 AM 

Mechanisms Of Biological Regulation By Highly Dynamic Protein 

Complexes. Julie Forman-Kay, Tanja Mittag, Jennifer M. Baker, 

Joseph A. Marsh. 

13-SYMP 8:45 AM 

The Modular Logic of Cell Signaling Systems. Wendell Lim. 

14-SYMP 9:15 AM 

Allosteric effects and regulation of signaling: the ubiquitin E3 ligases. 

Ruth Nussinov. 

15-SYMP 9:45 AM 

Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto- 

Oncoprotein. Michael K. Rosen, Pilong Li, Ilidio R. S Martins, 

Gaya K. Amarasinghe, Bingke Yu, Junko Umetani. 

8:15 AM–10:15 AM, BALLROOM WEST 

SYMPOSIUM 2 

Many Ways to Regulate a Molecular Motor 

Chair: Samantha Harris, University of California, Davis 

16-SYMP 8:15 AM 

Force Dependent Regulation of Myosin-I. Michael Ostap. 

17-SYMP 8:45 AM 

Structural Basis for The Regulation of Drosophila Myosin 7a. 

James R. Sellers, Yi Yang, Thomas Baboolal, Verl Siththanandan, 

Matthew L. Walker, Peter J. Knight, Michelle Peckham. 

18-SYMP 9:15 AM 

The Ups and Downs of Smooth Muscle Myosin Regulation. 

Kenneth A. Taylor. 

19-SYMP 9:45 AM 

Switching Gears with Myosin Binding Protein-C. Samantha P. Harris, 

Justin F. Shaffer, Kristina L. Bezold, Robert W. Kensler. 

8:15 AM–10:15 AM, ROOM 102 A/B 

PLATFORM A 

Protein Conformation 

Co-Chairs: Martina Huber, Leiden University, Netherlands 

Ali Rana Atilgan, Sabanci University, Turkey 

20-PLAT 8:15 AM 

Active Unfolding of Collagen is not Required for Collagenolysis to Occur in 

Solution. Ramon Salsas-Escat, Collin M. Stultz. 

21-PLAT 8:30 AM 

Lipid Bilayer Coated Gold Nanoparticles Provide Insight Into Proteins’ 

Conformational Changes. Stephan M. Woods, Katrice E. King, 

Avishek Kumar, Roberta E. Redfern, Alonzo Ross, Arne Gericke. 

22-PLAT 8:45 AM 

Extended conformations in alanine peptides. Kang Chen, Zhigang Liu, 

Chunhui Zhou, W. Clay Bracken, Neville R. Kallenbach. 

23-PLAT 9:00 AM 

A Solution NMR and Crystallographic Study of the Role of the Quaternary 

Shift in the Allosteric Regulation of Phosphofructokinase from B. stearothermophilus. 

Rockann Mosser, Manchi Reddy, James C. Sacchettini, 

Tatyana Igumenova, Gregory D. Reinhart. 

24-PLAT 9:15 AM 

From Data or Dogma? The Myth of the Ideal Helix. 

Daniel J. Kuster, Sergio Urahata, Jay W. Ponder, Garland R. Marshall. 

25-PLAT 9:30 AM 

Conformation Coupling Between The I-like Domain Alpha7 Helix And 

The Hybrid Domain Of Beta3 Integrins. Jizhong Lou, Wei Chen, 

Mei-Yin Chou, Cheng Zhu. 

26-PLAT 9:45 AM 

Spin-label EPR of alpha-Synuclein on Vesicles Reveals Antiparallel 

Arrangement and Differences in the Membrane Binding Affinity of the two 

Helices. Martina Huber, Malte Drescher, Frans Godschalk, 

Sergey Milikisyants, Gertjan Veldhuis, Bart van Rooijen, 

Vinod Subramaniam. 

27-PLAT 10:00 AM 

A Coarsened Network Model Reveals Allosteric Machinery. 

Ali Rana Atilgan, Canan Atilgan. 

8:15 AM–10:15 AM, ROOM 104 A/B 

PLATFORM B 

Biotechnology & Bioengineering 

Co-Chairs: Xiao Wang, Boston University 

Brandon McNaughton, University of Michigan 

28-PLAT 8:15 AM 

Sequencing Paired Reads using True Single Molecule Sequencing (tSMS) 

Technology. Jeff G. Reifenberger, Doron Lipson, Jennifer Colonell, 

Tal Raz, Bill Pierceall, John Thompson, Patrice Milos. 

29-PLAT 8:30 AM 

Self-assembly via Active Transport By Biomolecular Motors. 

Parag Katira, Isaac Luria, Shruti Seshadri, Henry Hess. 

Biophysical Society 53 rd Annual Meeting 

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30-PLAT 8:45 AM 

Single Cell Detection and Analysis with Asynchronous Rotation of Driven 

Magnetic Microspheres. Brandon H. McNaughton, Paivo Kinnunen, 

Rodney R. Agayan, Ron G. Smith, Alan J. Hunt, Raoul Kopelman, Roy 

Clarke. 

31-PLAT 9:00 AM 

Remote Steering of C. Elegans Using Nanoparticle Heating. 

Heng Huang, Savas Delikanli, Hao Zeng, Arnd Pralle. 

32-PLAT 9:15 AM 

Probing Conformational Changes In Rhodopsin With Site-specific Azido 

Labels. Shixin Ye, Thomas Huber, Reiner Vogel, Thomas P. Sakmar. 

33-PLAT 9:30 AM 

Towards Mapping Domain Boundaries of Proteins. Shambaditya Saha, 

Thomas D. Pollard. 

34-PLAT 9:45 AM 

A Protein Interaction Network generated from Streptococcus Pneumoniae. 

Doron Gerber, Sebastian J. maerkl, Stephen R. Quake. 

35-PLAT 10:00 AM 

Diversity-Based Design of Synthetic Gene Networks with Desired 

Functions. Xiao Wang, Tom Ellis, James J. Collins. 

8:15 AM–10:15 AM, ROOM 151 A/B 

PLATFORM C 

Oxidative Phosphorylation & Mitochondrial 

Metabolism 

Co-Chairs: Pia Vogel, Southern Methodist University 

John Miller, University of Houston 

36-PLAT 8:15 AM 

Molecular Basis of Substrate Selectivity in the ADP/ATP Carrier. 

Yi Wang, Emad Tajkhorshid. 

37-PLAT 8:30 AM 

VDAC Regulation by Cytosolic Proteins. Tatiana K. Rostovtseva. 

38-PLAT 8:45 AM 

A Microcompartment Of Mitochondrial Nucleoside Diphosphate Kinase: 

Cardiolipin Interaction And Coupling Of Nucleotide Transfer With 

Respiration. Uwe Schlattner, Malgorzata Tokarska-Schlattner, Ivan Dinh, 

Mathieu Boissan, Marie-Lise Lacombe. 

39-PLAT 9:00 AM 

Using Two-photon Excited Fluorescence Intensity- and Lifetime-based 

NADH Imaging to Investigate Cochlea Metabolism. LeAnn M. Tiede, 

Jorge A. Vergen, Clifford Hecht, Richard Hallworth, Michael G. Nichols. 

40-PLAT 9:15 AM 

Mitochondrial Energy Metabolism and Ca 21 Handling in Pancreatic 

Beta-cells. A System Analysis Approach. Leonid E. Fridlyand, 

Louis H. Philipson. 

41-PLAT 9:30 AM 

Modeling Regulation of Mitochondrial Free Ca 21 by ATP/ADP- 

Dependent Ca 21 Buffering. Ranjan K. Dash, Matthew D. Thompson, 

Kalyan C. Vinnakota, Johan Haumann, Mohammed Aldakkak, 

Amadou K.S. Camara, David F. Stowe, Beard A. Daniel. 

42-PLAT 9:45 AM 

The External Stalk of the FoF1-ATPase: 3D-Structure of the b-Dimer. 

Oleg A. Volkov, Susan J. Pandey, John G. Wise, Pia D. Vogel. 

43-PLAT 10:00 AM 

Torque Generation Mechanism of ATP Synthase and Other Rotary Motors. 

John H. Miller, Vijayanand Vajrala, Hans L. Infante, James R. Claycomb. 


8:15 AM–10:15 AM, ROOM 153 A/B 

PLATFORM D 

RNA Folding & Ribosome 

Co-Chairs: David Rueda, Wayne State University 

Kathleen Hall, Washington University School of Medicine 

44-PLAT 8:15 AM 

Laser Assisted Single-molecule Refolding. Rui Zhao, Elvin Alemán, 

David Rueda. 

45-PLAT 8:30 AM 

Single Molecule Analysis of Group I Ribozyme Folding Reveals Pronounced 

Ruggedness Throughout Its Folding Landscape. Sergey Solomatin, 

Max Greenfeld, Steven Chu, Dan Herschlag. 

46-PLAT 8:45 AM 

Identifying Energy Barriers in RNA Folding Through Kinetic Model 

Enumeration. Joshua S. Martin, Joerg Schlatterer, Michael Brenowitz, 

Alain Laederach. 

47-PLAT 9:00 AM 

Uncovering The Mechanism Used By Drosophila Snf Protein To 

Specifically Bind Two RNAs. Kathleen B. Hall, Gregory DeKoster, 

Sandra Williams. 

48-PLAT 9:15 AM 

Parallel Pathways in 30S Ribosome Assembly. William K. Ridgeway, 

Zahra Shajani, David P. Millar, James R. Williamson. 

49-PLAT 9:30 AM 

Visualizing tmRNA after its accommodation in the Ribosome. 

Jie Fu, Jianlin Lei, Iowna Wower, Jacek Wower, Joachim Frank. 

50-PLAT 9:45 AM 

Coupling Of Ribosome And tRNA Dynamics During Translation. 

Ruben L. Gonzalez, Jr, Jingyi Fei, Samuel H. Sternberg. 

51-PLAT 10:00 AM 

Regulation of the Protein-conducting Channel by a Bound Ribosome. 

James C. Gumbart, Leonardo G. Trabuco, Elizabeth Villa, 

Eduard Schreiner, Christopher B. Harrison, Klaus Schulten. 

8:15 AM–10:15 AM, ROOM 252 A/B 

PLATFORM E 

Excitation-Contraction Coupling 

Co-Chairs: Ye Chen-Izu, University of Kentucky 

Bjorn Knollman, Vanderbilt University Medical Center 

52-PLAT 8:15 AM 

Impaired Sarcoplasmic Reticulum Calcium Release In Skeletal Muscle Fibers 

From Myotubularin-Deficient Mice. Norbert Weiss, Lama Al-Qusairi, 

Celine Berbey, Bruno Allard, Jean Louis Mandel, Jocelyn Laporte, 

Anna Buj-Bello, Vincent Jacquemond. 

53-PLAT 8:30 AM 

Changes of EC-coupling and RyR Calcium Sensitivity in Dystrophic mdx 

Mouse Cardiomyocytes. Nina D. Ullrich, Mohammed Fanchaouy, 

Konstantin Gusev, Eva Polakova, Natalia Shirokova, Ernst Niggli. 

54-PLAT 8:45 AM 

The Skeletal L-type Ca 21 Current is a Major Contributor to Excitation- 

Coupled Ca 21 Entry (ECCE) . Roger A. Bannister, Kurt G. Beam. 

55-PLAT 9:00 AM 

Post-Tetanic Calcium Transients In Adult Skeletal Muscle Fibers Are 

Frequency-Dependent And Fiber Type Specific. Mariana Casas, 

Reinaldo Figueroa, Isaac Garcia, Enrique Jaimovich. 

56-PLAT 9:15 AM 

Negative Relationship Between Fractional SR Ca 21 Release and Stimulation 

Rate. Rosana A. Bassani, Rafael A. Ricardo, José WM Bassani. 

57-PLAT 9:30 AM 

Flecainide Inhibits Cardiac Ryanodine Channels And Spontaneous 

Sarcoplasmic Reticulum Calcium Release In Casq2 Null Myocytes. 

Derek Laver, Nagesh Chopra, Bjorn C. Knollmann. 

58-PLAT 9:45 AM 

CaMKII Regulates L-type Ca 21 Current during Action Potential Plateau and 

Repolarization _ a Direct Link to Arrhythmias. Tamas Banyasz, Leighton T. 

Izu, Ye Chen-Izu. 

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59-PLAT 10:00 AM 

Simultaneous Recordings of Cell Shortening and cAMP or Calcium 

Transients Reveal Differential Regulation of Cardiac Contractility by Specific 

Phosphodiesterases. Delphine Mika, Jérôme Leroy, Patrick Lechêne, 

Grégoire Vandecasteele, Rodolphe Fischmeister. 

8:15 AM–10:15 AM, ROOM 254 A/B 

PLATFORM F 

Voltage-gated Na Channels 

Co-Chairs: Robert Ruff, Veterans Affairs Medical Center, Clevland 

Catherine Morris, Ottawa Hospital Res Institute 

60-PLAT 8:15 AM 

How Myasthenia Gravis Alters the Safety Factor for Neuromuscular 

Transmission. Robert L. Ruff, Vanda A. Lennon. 

61-PLAT 8:30 AM 

NaV1.7 Gain-of-function Mutations As A Continuum: A1632E Displays 

Physiological Changes Associated With Erythromelalgia And Paroxysmal 

Extreme Pain Disorder Mutations And Produces Symptoms Of Both 

Disorders. Mark Estacion, Sulayman D. Dib-Hajj, Paul J. Benke, 

R H. M. te Morsche, Emmanuella M. Eastman, Lawrence J. Macala, 

Joost P.H. Drenth, Stephen G. Waxman. 

62-PLAT 8:45 AM 

Using Potassium Channels As Reporters To Deconstruct The Function And 

Pharmacology Of Sodium Channel Voltage Sensors. Frank Bosmans, 

Marie-France Martin-Eauclaire, Kenton J. Swartz. 

63-PLAT 9:00 AM 

Persistently “Leaky” Nav Channels In Traumatized Axons: Lowered Barriers 

To Nav1.6 Voltage Sensor Motions In Blebbed Plasma Membrane As A 

Possible Explanation. Wei Lin, Peter F. Juranka, Catherine E. Morris. 

64-PLAT 9:15 AM 

Expression, Purification and Biophysical Characterization of a Superfamily of 

Prokaryotic Voltage-gated Sodium Channels. Emily C. McCusker, 

B. A. Wallace. 

65-PLAT 9:30 AM 

Chimeric bacterial-human NaV1.7 sodium channels expressed in E. coli. 

Andrew M. Powl, B. A. Wallace. 

66-PLAT 9:45 AM 

Block of Tetrodotoxin-sensitive, Nav1.7, and Tetrodotoxin-resistant, 

Nav1.8, Na 21 Channels by Ranolazine. Sridharan Rajamani, 

John Shryock, Luiz Belardinelli. 

67-PLAT 10:00 AM 

Insecticide Binding to Voltage-gated Sodium Channels. 

Andrias O. O’Reilly, TG Emyr Davies, Peter N.R. Usherwood, 

Ian R. Mellor, Martin S. Williamson, Linda M. Field, B. A. Wallace. 

9:00 AM–10:30 AM, ROOM 251 

CPOW COMMITTEE MEETING 

10:00 AM–5:00 PM, HALL A 

EXHIBITS 

10:15 AM–11:00 AM, EXHIBIT HALL LOUNGE 

COFFEE BREAK 

10:30 AM–1:00 PM, ROOM 153C 

UNDERGRADUATE STUDENT SYMPOSIUM 

10:45 AM–12:45 PM, BALLROOM EAST 

SYMPOSIUM 3 

The Biophysics of HIV 

Chair: David Millar, Scripps Research Institute 

68-SYMP 10:45 AM 

Nucleic Acid Chaperone Activity of Retroviral Gag and Nucleocapsid 

Proteins. Karin Musier-Forsyth. 

69-SYMP 11:15 AM 

Assembly of Ribonucleoproteins Involved in Viral RNA Trafficking. 

David Millar, Stephanie J. Pond, William Ridgeway, Rae Robertson. 

70-SYMP 11:45 AM 

Insights Into The Mechanism Of Retroviral Genome Packaging And 

Assembly. Michael Summers. 

71-SYMP 12:15 PM 

Mechanistic Studies of HIV Budding. Wesley I. Sundquist. 

10:45 AM–12:45 PM, BALLROOM WEST 

SYMPOSIUM 4 

Systems Biology 

Chair: Ravi Iyengar, Mount Sinai School of Medicine 

72-SYMP 10:45 AM 

Designing Biological Systems. Pamela Silver. 

73-SYMP 11:15 AM 

Design principles of biological circuits. Uri Alon. 

74-SYMP 11:45 AM 

Nature, nurture, or just blind chance: Stochastic gene expression and its consequences. 

Alexander van Oudenaarden. 

75-SYMP 12:15 PM 

Information is critical for cellular life. Ravi Iyengar. 

10:45 AM–12:45 PM, ROOM 102 A/B 

MINISYMPOSIUM 1 

Virus Mechanics: Material Properties and Assembly 

Co-Chairs: William Gelbart, University of California, Los Angeles 

Christoph Schmidt, Georg-August-Universität, Gottingen, Germany 

76-MINISYMP 10:45 AM 

Biophysical Studies of Virus Particles and their Maturation: Insights into 

Elegantly Programmed Nano-machines. Jack Johnson. 


Modeling the Size and Structure of RNA: Viral vs. Non-viral Sequences. 

Avinoam Ben-Shaul, Aron M. Yoffe, Peter Prinsen, William M. Gelbart. 


Structural Mechanics of Viral Shells: Stretching the Limits of Continuum 

Models. William S. Klug. 


The Influenza Virus Mechanical Properties Are Dominated By Its Lipid 

Envelope. Frederic Eghiaian, Iwan Alexander Schaap, 

Amédée Des Georges, John James Skehel, Claudia Veigel. 

80-MINISYMP 12:05 PM 

Single-Molecule Studies of Viral DNA Packaging with Optical Tweezers: 

Molecular Motor Function and DNA Confinement. Douglas E. Smith, 

James M. Tsay. 

81-MINISYMP 12:25 PM 

Response of Viral Shells under Nano-Indentation. Irena L. Ivanovska, 

Pedro J. de Pablo, Roberto Miranda, Melissa M. Gibbons, 

Jean-Philipe Michel, Gijs J.L. Wuite, Fred C. MacKintosh, 

Jose L. Carrascosa, William S. Klug, Robijn F. Bruinsma, 

Charles M. Knobler, Christoph F. Schmidt. 


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10:45 AM–12:45 PM, ROOM 104 A/B 

PLATFORM G 

Imaging & Optical Microscopy 

Chair: Claire Brown, McGill University 

Shaohui Huang, University of Massachusetts Medical School 

82-PLAT 10:45 AM 

Stereo Photoactivated Localization Microscopy for Super-Resolution 

3D Bioimaging. Jianyong Tang, Alipasha Vaziri, Charles V. Shank. 

83-PLAT 11:00 AM 

Flurogen Activating Peptides for Single Molecule Localization based 

Superresolution. Keith A. Lidke, Qi Yan, Sierd C. Smith, Nikolai Joseph, 

Marcel Bruchez. 

84-PLAT 11:15 AM 

Three-dimensional Super-resolution Fluorescence Microscopy and Its 

Application to Clathrin Mediated Endocytosis. Bo Huang, Min Wu, 

Wenqin Wang, Pietro De Camilli, Xiaowei Zhuang. 

85-PLAT 11:30 AM 

STED Nanoscopy in Living Cells using Live Cell Compatible Markers. 

Katrin I. Willig, Birka Hein, U. Valentin Nägerl, Stefan W. Hell. 

86-PLAT 11:45 AM 

Multilayer Three-dimensional Super-resolution Imaging of Thick Biological 

Samples. Alipasha Vaziri, Jianyong Tang, Hari Shroff, Charles Shank. 

87-PLAT 12:00 PM 

Single Molecule Tracking With Light Sheet-Based Microscopy In Vivo. 

Jörg Ritter, Roman Veith, Jan Peter Siebrasse, Ulrich Kubitscheck. 

88-PLAT 12:15 PM 

Ultra-high resolved Multi-Beam-Two-Photon-Striped-Illumination- 

Microscopy (MBTPSIM): Studying the Molecular Nature of Cell-Cell 

Interactions. Raluca Niesner, Jan Leo Rinnenthal. 

89-PLAT 12:30 PM 

A Programmable Light Engine For Quantitative TIRF And HILO Imaging. 

Marcel van ‘t Hoff, Vincent de Sars, Martin Oheim. 

10:45 AM–12:45 PM, ROOM 151 A/B 

PLATFORM H 


Co-Chairs: Beate Kloesgen, University of Southern Denmark 

Brigitte Papahadjopoulos-Sternberg, NanoAnalytical Lab 

90-PLAT 10:45 AM 

Charges in phospholipid layers. Malgorzata Hermanowska, Goran Bijelic, 

Corina Ciobanasu, Ulrich Kubitscheck, Per Claesson, Beate M. Klösgen. 

91-PLAT 11:00 AM 

Domain/Raft Exploration in Lipid Mono- & Bilayer by Freeze-fracture 

Electron Microscopy on Nano-Resolution Scale. 

Brigitte Papahadjopoulos-Sternberg. 

92-PLAT 11:15 AM 

Sterol Uptake From Liposomes By MbCD Is Influenced By The Extent Of 

Sterol Superlattice In The Membrane. Berenice Venegas, 

Parkson L.-G. Chong. 

93-PLAT 11:30 AM 

Lipid Diffusion In Domain-forming Bilayers Studied By Pfg-nmr. 

Goran Lindblom, Greger Orädd. 

94-PLAT 11:45 AM 

Lipid Sorting In Membranes Nanotubes. 

Benoit SORRE, Andrew Callan-Jones, Jean-Baptiste Manneville, 

Pierre Nassoy, Jean-Francois Joanny, Jacques Prost, Bruno Goud, 

Patricia Bassereau. 

95-PLAT 12:00 PM 

Stoichiometries and Energetics of Cationic Nanoparticle-Membrane 

Complexes. Christopher V. Kelly, Meghan G. Liroff, L. Devon Triplett, 

Douglas G. Mullen, James R. Baker, Bradford G. Orr, Mark M. Banaszak 

Holl. 


96-PLAT 12:15 PM 

The Delivery of Lipidic Compounds to Model Membrane Interfaces by 

Non-lamellar Liquid Crystalline Nano-particles. Pauline Vandoolaeghe, 

Adrian R. Rennie, Richard A. Campbell, Robert K. Thomas, Fredrik Höök, 

Giovanna Fragneto, Justas Barauskas, Fredrik Tiberg, Tommy Nylander. 

97-PLAT 12:30 PM 

Construction Of A Tethered-bilayer Lipid Membrane By Physiosorption Of 

Glycolipid GM1 To A Hydrophilically Modified Gold Surface. 

Annia H. Kycia, Jacek Lipkowski, Rod Merrill. 

10:45 AM–12:45 PM, ROOM 153 A/B 

PLATFORM I 

DNA, RNA Structure & Conformation 

Co-Chairs: Laura Finzi, Emory University 

Alexander Vologodski, New York University 

98-PLAT 10:45 AM 

Computational and Experimental Determination of the tRNA-like Structure 

in the 39UTR of the Turnip Crinkle Virus (TCV). Wojciech K. Kasprzak, 

Yaroslava G. Yingling, Anne E. Simon, Bruce A. Shapiro. 

99-PLAT 11:00 AM 

Pre-stressed Tensegrity Structures built from DNA. Tim Liedl, 

Donald E. Ingber, William M. Shih. 

100-PLAT 11:15 AM 

The Role of Sequence-Dependent Mechanics in DNA Looping. 

David P. Wilson, J.C. Meiners, Todd Lillian, Alexei Tkachenko, 

Noel C. Perkins. 

101-PLAT 11:30 AM 

Chromatin Organization in E.coli. Paul Wiggins, Joshua Martin, 

Jane Kondev. 

102-PLAT 11:45 AM 

Structure and Dynamics of the Bacterial Chromosome. 

Nastaran Hadizadeh, John F. Marko. 

103-PLAT 12:00 PM 

DNA Strand Exchange on Liposome Surfaces. Karolin Frykholm, 

Francesca Baldelli Bombelli, Bengt Nordén, Fredrik Westerlund. 

104-PLAT 12:15 PM 

Load Dependence of the Degree of Cooperativity of the Unwinding of Dna 

Helix. Pasquale Bianco, Mario Dolfi, Vincenzo Lombardi. 

105-PLAT 12:30 PM 

Unraveling the Structure of a Single DNA During Overstretching Using 

Multicolor Fluorescence Imaging. Peter Gross, Joost van Mameren, 

Geraldine Farge, Pleuni Hooijman, Maria Falkenberg, Mauro Modesti, 

Erwin J.G. Peterman, Gijs J.L. Wuite. 

10:45 AM–12:45 PM, ROOM 252 A/B 

PLATFORM J 

Calcium Fluxes, Sparks, & Waves 

Co-Chairs: Laszelo Czernoch, University of Debrecen, Hungary 

Eric Sobie, Mt. Sinai School of Medicine 

106-PLAT 10:45 AM 

Calcium Flickers Steer Cell Migration. Chaoliang Wei, Xianhua Wang, 

Min Chen, Kunfu Ouyang, Long-Sheng Song, Heping Cheng. 

107-PLAT 11:00 AM 

Ca21 Spark Restitution In Ventricular Myocytes With Modified Ryanodine 

Receptor Gating. Hena R. Ramay, Eric A. Sobie. 

108-PLAT 11:15 AM 

Quarky Calcium Sparks in Heart. Didier X.P. Brochet, Dongmei Yang, 

Wenjun Xie, Heping Cheng, W. J. Lederer. 

109-PLAT 11:30 AM 

Concerted Phosphodiesterase (PDE) Subtype Activity Modulates Ca 21 

Influx Through L-type Ca 21 Channels To Regulate Spontaneous Firing 

of Rabbit Sinoatrial Node Cells (SANC). Tatiana M. Vinogradova, 

Alexey E. Lyashkov, Harold Spurgeon, Edward G. Lakatta. 

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110-PLAT 11:45 AM 

Development of Calcium Handling Defects During Aging in Spontaneously 

Hypertensive Rats. Sunil Kapur, Gary L. Aistrup, Rohan Sharma, 

Jiabo Zheng, James E. Kelly, Alan H. Kadish, William Balke, 

J Andrew Wasserstrom. 

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111-PLAT 12:00 PM 

Decreased Arrhythmia Probability After Exercise Training In Post Infarction 

Heart Failure. Tomas O. Stølen, Morten A. Høydal, Godfrey L. Smith, 

Ulrik Wisløff. 

112-PLAT 12:15 PM 

Ca21 Spark Activity in Intact Dystrophin-Deficient mdx Muscle during 

Osmotic Challenge is Triggered by Mechanosensitive Pathways. 

Martin DH Teichmann, Frederic von Wegner, Rainer HA Fink, 

Jeffrey S. Chamberlain, Bradley S. Launikonis, Boris Martinac, 

Oliver Friedrich. 

113-PLAT 12:30 PM 

Fluvastatin Alters Both The Calcium Homeostasis And Cell Proliferation In 

Cultured Myotubes And The Calcium Release Events In Adult Muscle 

Fibers Of The Rat. Marta Fuzi, Zoltan Palitz, Laszlo Szabo, Janos Vincze, 

Peter Szentesi, Gyorgy Paragh, Pal Kertai, Laszlo Csernoch. 

10:45 AM–12:45 PM, ROOM 254 A/B 

PLATFORM K 

Ion Channels, Other 

Chair: Cristian Ionescu-Zanetti, Fluxion Biosciences 

Marco Colombini, University of Maryland 

114-PLAT 10:45 AM 

A Microfluidic Approach Enables Ligand Gated Ion Channel Recording 

from Cell Ensembles. Cristian Ionescu-Zanetti, Ian Spencer, Nianzhen Li, 

Jeff Jensen. 

115-PLAT 11:00 AM 

Discovery Of Photochromic Ligands That Block Voltage-gated K1 

Channels At The Internal TEA Binding Site. Matthew R. Banghart, 

Alexandre Mourot, Doris L. Fortin, Richard H. Kramer, Dirk Trauner. 

116-PLAT 11:15 AM 

Gaining control over membrane potential by light using Channelrhodopsin. 

Anton Rösler, Peter Hegemann, Matthias Prigge. 

117-PLAT 11:30 AM 

Determining The Coupling Between Subunits In Kcsa Using Single 

Channel Fluorescence Spectroscopy. Hugo McGuire, Francisco Bezanilla, 

Rikard Blunck. 

118-PLAT 11:45 AM 

Light-gated Ion Channels Based on Gramicidin A. Mike X. Macrae, 

Michael Mayer, Jerry Yang. 

119-PLAT 12:00 PM 

Lipid Channels: Positive and Negative Cooperativity and Regulation by 

Proteins. Vidyaramanan Ganesan, Meenu N. Perera, Leah Siskind, 

Zdzislaw Szulc, Alicja Bielawska, Marco Colombini. 

120-PLAT 12:15 PM 

Ryanodine Receptors Alter Store-Operated Ca 21 Influx In Resting And 

Activated Human T Cells By Regulating Ca 21 Retention Within The Store. 

Sepehr Dadsetan, Liudmila Zakharova, Alla Fomina. 

121-PLAT 12:30 PM 

The Sodium Channel Accessory Subunit Navb1 Associates With Brain 

Kv4.2 And Modulates The Functional Expression Of Kv4.2-encoded 

Channels. Celine Marionneau, Aaron Norris, Reid R. Townsend, 

Andrew J. Link, Jeanne M. Nerbonne. 

11:00 AM–12:00 PM, ROOM 105 

INTERNATIONAL RELATIONS 

COMMITTEE MEETING 

11:00 AM–12:30 PM, ROOM 103 

EXHIBITOR PRESENTATION 

Veeco Instruments 

12:00 PM–1:00 PM, ROOM 105 

INTERNATIONAL TRAVEL 

AWARDEE LUNCHEON 

The International Affairs Committee will honor the International Travel Grant 

Awardees at this annual luncheon. 

12:00 PM–2:00 PM, 253 A/B 

CAREER ROUNDTABLE LUNCHEON 

This roundtable career luncheon, hosted by CPOW, is aimed at helping attendees, 

particularly those early in their careers, navigate the complex waters of a 

faculty-level research career. Popular topics include conflict resolution, how to 

establish a successful collaboration, where to look for alternative research funding, 

and how to select a good group of mentors for career development. 

Approximately one dozen established investigators with expertise in one or 

more of the discussion areas and a keen desire to mentor participate in this 

event. The luncheon begins with each table holding a roundtable discussion on 

a given topic. It ends with a representative from each table summarizing the responses 

to their particular topic, providing a forum for all participants to learn 

from each roundtable discussion. Pre-registration was required. 

12:00 PM–2:00 PM, ROOM 152 

PUBLIC AFFAIRS COMMITTEE MEETING 

1:00 PM–2:30 PM, ROOM 253C 

NEGOTIATING THE TRANSITION: 

DIFFERENCES BETWEEN ACADEMIA 

AND INDUSTRY 

The panelists, from academia and industry, will compare their experiences of 

the transition between postdoc and a more permanent position and provide advice 

on the steps involved in this transition. This panel is part of a popular series 

hosted by the Early Careers Committee. 

Panelists: 

Isabelle Marcotte, Université du Québec á Montréal, Canada 

Jessica Dawson, EMD Serono, Inc. 

Dustin Armstrong, 453 BioScience, Inc. 

Aldrin Gomes, University of California, Davis 

1:00 PM–3:00 PM, HALL A 

GRADUATE INSTITUTION FAIR 

Sponsored by the Education Committee, this fair will introduce undergraduate 

students to colleges and universities with leading graduate training programs in 

biophysics. 

1:45 PM–3:00 PM, EXHIBIT HALL LOUNGE 

SNACK BREAK 

1:45 PM–3:45 PM, HALL A 

SUNDAY POSTER PRESENTATIONS 

(For a complete listing of Sunday Poster presentations, see page 19.) 

Posters will be posted all day long. Authors with odd-numbered boards will 

present from 1:45 PM–2:45 PM, and those with even-numbered boards will 

present from 2:45 PM–3:45 PM. Additional hours (day or evening) may be 

posted by the authors as desired. Also note, paper may be left so that visitors 

may request an appointment. 


2:30 PM–4:30 PM, 153C 

SCIENCE POLICY IN THE 

OBAMA ADMINISTRATION 

With a new President in the Oval Office and new leadership at federal agencies 

government-wide, what is in store for science? Join renowned experts on politics 

and science policy for a discussion of the changes that occur when a new administration 

takes office, as well as the expected role of science policy in the 

Obama Administration. This session is sponsored by the Public Affairs 

Committee. 

Speakers: 

The Honorable John Porter, Chairman, Research! America 

Jeremy Berg, Director, NIGMS, NIH 

Additional speaker to be announced 

3:30 PM–4:30 PM, ROOM 152 

EARLY CAREERS COMMITTEE MEETING 

4:00 PM–6:00 PM, BALLROOM EAST 

SYMPOSIUM 5 

How Proteins Move on DNA 

Chair: Smita Patel, UMDNJ RWJ Medical School 

992-SYMP 4:00 PM 

High-resolution Optical Trap Measurements Of A Ringed DNA 

Translocase. Yann R. Chemla, Jeffrey R. Moffitt, K. Aathavan, 

Shelley Grimes, Paul J. Jardine, Dwight L. Anderson, Carlos Bustamante. 

993-SYMP 4:30 PM 

High throughput assays for visualizing individual protein-DNA interactions. 

Eric Greene. 

994-SYMP 5:00 PM 

Coupling of two motors: T7 helicase-primase and DNA polymerase. 

Smita Patel, Manjula Pandey, Salman Syed, Taekjip Ha, Daniel Johnson, 

Michelle Wang. 

995-SYMP 5:30 PM 

Translocation and Unwinding by DnaB. Omar A. Saleh. 

4:00 PM–6:00 PM, BALLROOM WEST 

SYMPOSIUM 6 

Store-operated Calcium Channels in the 

Molecular Age 

Chair: Richard Lewis, Stanford University School of Medicine 

996-SYMP 4:00 PM 

STIMulating Calcium Entry at ER-Plasma Membrane Junctions. 

Jen Liou, Onn Brandman, Tobias Meyer. 

997-SYMP 4:30 PM 

Calcium Signals In Lymphocyte Activation And Disease. Stefan Feske. 

998-SYMP 5:00 PM 

Structural And Mechanistic Insights Into Stim1-mediated Initiation Of Store 

Operated Calcium Entry. Mitsu Ikura. 

999-SYMP 5:30 PM 

A Molecular Mechanism for CRAC Channel Activation. 

Richard S. Lewis. 

4:00 PM–6:00 PM, ROOM 102 A/B 

PLATFORM L 

Membrane Protein Structure 

Co-Chairs: Linda Columbus, University of Virginia 

Constance Jeffery, University of Illinois Chicago 

1000-PLAT 4:00 PM 

High Throughput Coarse-Grained Simulations of the Insertion of 

Transmembrane Helices. Benjamin A. Hall, Alan Chetwynd, 

Richard Franzese, Mark SP Sansom. 


1001-PLAT 4:15 PM 

Structural models of Alzheimer’s Abeta channels. H. R. Guy, 

Stewart R. Durell, Yinon Shafrir. 

1002-PLAT 4:30 PM 

Pore Formation and Structure of the Twin Arginine Translocase Subunit 

TatA from B. subtilis. Stephan L. Grage, Torsten H. Walther, 

Claudia Muhle, Olga Nolandt, Marco J. Klein, Nadine Roth, 

Sonja D. Mueller, Philip Callow, Anna de Angelis, Fabian V. Filipp, 

Stanley J. Opella, Anne S. Ulrich. 

1003-PLAT 4:45 PM 

Lysophospholipid Micelles Sustain Diacylglycerol Kinase in Active and 

Stable Form for Biochemical and Structural Studies. Endah S. Sulistijo, 

Charles Ellis, Megan Wadington, Charles R. Sanders. 

1004-PLAT 5:00 PM 

Mixing and Matching Detergents for Membrane Protein NMR Structure 

Determination. Linda Columbus, Jan Lipfert, Kalyani Jambunathan, 

Daniel A. Fox, Adelene Y.L. Sim, Sebastian Doniach, Scott A. Lesley. 

1005-PLAT 5:15 PM 

Structure and Dynamics of TM Domains of Human Glycine Receptor in 

LPPG Micelles. Dejian Ma, Yuanyuan Jia, Pei Tang, Yan Xu. 

1006-PLAT 5:30 PM STUDENT TRAVEL AWARDEE 

Conformational Cycle Of A Bacterial Homolog Of Human 

Neurotransmitter Sodium Symporters. Derek Claxton, Matthias Quick, 

Lei Shi, Lynn Chung, Yongfang Zhao, Harel Weinstein, 

Jonathan A. Javitch, Hassane S. Mchaourab. 

1007-PLAT 5:45 PM 

X-ray Footprinting Studies on Photoactivation of Bovine Rhodopsin. 

Sayan Gupta, Thomas Angel, Beata Jastrzebska, Krzysztof Palczewski, 

Mark R. Chance. 

4:00 PM–6:00 PM, ROOM 104 A/B 

PLATFORM M 

Cell & Bacterial Mechanics Motility 

Co-Chairs: Dennis Discher, University of Pennsylvania 

David Odde, University of Minnesota 

1008-PLAT 4:00 PM 

Physical Description of Mitotic Spindle Orientation During Cell Division. 

Andrea Jiménez-Dalmaroni, Manuel Théry, Victor Racine, 

Michel Bornens, Frank Jülicher. 

1009-PLAT 4:15 PM 

Taking Control of the Bacterial Flagellar Motor. Simon Rainville, 

Mathieu Gauthier, Dany Truchon, Alexandre Bastien. 

1010-PLAT 4:30 PM 

How Molecular Motors Shape The Flagellar Beat. Andreas Hilfinger, 

Ingmar Riedel-Kruse, Jonathon Howard, Frank Jülicher. 

1011-PLAT 4:45 PM 

Mechanics Of Neutrophil Motility On Compliant Gels Measured With 

Traction Force Microscopy. Daniel A. Hammer, Risat Jannat, 

Micah Dembo. 

1012-PLAT 5:00 PM 

Mechanics in neuronal development. Kristian Franze, Hanno Svoboda, 

Pouria Moshayedi, Andreas Christ, James Fawcett, Josef A. Kas, 

Christine E. Holt, Jochen Guck. 

1013-PLAT 5:15 PM 

Stem Cell Biophysics: Pre-differentiation Dynamics of Stress Fiber 

Polarization on Elastic Matrices. Andre E.X. Brown, Florian Rehfeldt, 

Allison L. Zajac, Dennis E. Discher. 

1014-PLAT 5:30 PM 

Contractile Force Generation Enhanced Tumor Cell Invasion, But 

Decreased Tumor Growth. Claudia T. Mierke, Benjamin Frey, 

Martina Fellner, Martin Herrmann. 

1015-PLAT 5:45 PM 

Pushing Off The Walls: A Mechanism Of Cell Motility In Confinement. 

Rhoda J. Hawkins, Matthieu Piel, Ana-Maria Lennon-Dumenil, 

Jean-François Joanny, Jacques Prost, Raphaël Voituriez. 

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4:00 PM–6:00 PM, ROOM 151 A/B 

PLATFORM N 

Membrane Dynamics & Bilayer Probes 

Co-Chairs: Christian Eggeling, Max Planck Institute, Germany 

Manuel Prieto, Institute Superior Technico 

16 

1016-PLAT 4:00 PM 

High-Resolution Far-Field Fluorescence STED Microscopy Reveals 

Nanoscale Details of Molecular Membrane Dynamics. Christian Eggeling, 

Christian Ringemann, Rebecca Medda, Birka Hein, Stefan W. Hell. 

1017-PLAT 4:15 PM 

3D Tracking of Antibody-Receptor Dynamics on RBL Cells. 

Nathan P. Wells, Guillaume A. Lessard, Peter M. Goodwin, 

James H. Werner. 

1018-PLAT 4:30 PM 

Physiological Membrane Tension Causes An Increase In Lipid Diffusion: 

A Single Molecule Fluorescence Study. Hari S. Muddana, 

Ramachandra Rao Gullapalli, Tristan Tabouillot, Peter J. Butler. 

1019-PLAT 4:45 PM 

Hydrophobic Mismatch: A universal Tool for Clustering, Demixing, and 

Sorting of Transmembrane Proteins. Ulrich Schmidt, Gernot Guigas, 

Matthias Weiss. 

1020-PLAT 5:00 PM 

Backbone Conformation and Dynamics of the Lipid-Modified Membrane 

Anchor of Human N-Ras Investigated by Solid-State NMR and Molecular 

Dynamics Simulations. Alexander Vogel, Guido Reuther, Kui-Thong Tan, 

Herbert Waldmann, Michael F. Brown, Scott E. Feller, Daniel Huster. 

1021-PLAT 5:15 PM 

Subdiffusion And Diffusion Of Lipid Atoms And Molecules: Relating The 

Dynamics Of Lipids To Neutron Scattering Experiments. 

Elijah Flenner, Jhuma Das, Maikel Rheinstädter, Ioan Kosztin. 

1022-PLAT 5:30 PM 

Towards Subcellular Tissue Sampling by Near-Field Laser Ablation: 

A ‘Protein Microscope’ to Map Peptide Distributions in Cells. 

Mark E. Reeves, Jasper Nijdam, Benjamin Gamari, Deepa Raghu, 

Andrew Gomella, Joan A. Hoffmann. 

1023-PLAT 5:45 PM 

A Biomolecular Photodiode For Imaging Of Cell Membrane Potential. 

Daniel R. Cooper. 

4:00 PM–6:00 PM, ROOM 153 A/B 

PLATFORM O 

Phototransduction: Signaling Events Downstream of 

Photon Absorption 

Co-Chairs: Robert Molday, University British Columbia 

Anita Zimmerman, Brown University 

1024-PLAT 4:00 PM 

Structure and Dynamics of Signal Transducing Membrane Complexes. 

Theodore G. Wensel, Feng He, Qiong Wang, Zhixian Zhang. 

1025-PLAT 4:15 PM 

Mouse Cone Opsins Require An Arrestin For Normal Inactivation. 

Edward N. Pugh, Jr., Sergei Nikonov, Jason Davis, Cheryl Craft. 

1026-PLAT 4:30 PM 

Light-Dependent Translocation of Arrestin in Rod Photoreceptors is 

Signaled through a Phospholipase C Cascade and Requires ATP. 

W. Clay Smith, Wilda Orisme, J. Hugh McDowell, Jian Li, Tobias 

Goldmann, Uwe Wolfrum. 

1027-PLAT 4:45 PM 

NCKX Reaction Cycle: ATP, Voltage And Ion Regulation. 

Natascia Vedovato, Giorgio Rispoli. 

1028-PLAT 5:00 PM 

Regulation Of Photoreceptor Guanylyl Cyclase By Ca21/Mg21 Exchange 

In GCAPs. Alexander M. Dizhoor, Elena V. Olshevskaya, 

Igor V. Peshenko. 

1029-PLAT 5:15 PM 

Phototransduction Cascade Inactivation Kinetics Depend on Experimental 

Solutions. Anthony W. Azevedo, Fred Rieke. 

1030-PLAT 5:30 PM 

Mathematical aspects of Variability and Variability Suppression of the Single 

Photon Response in Vertebrate Phototransduction. 

Emmanuele DiBenedetto, Paolo Bisegna, Giovanni Caruso, Lixin Shen, 

Daniele Andreucci, Vsevolod Gurevich, Heidi E. Hamm. 

1031-PLAT 5:45 PM 

Melanopsin Signalling: Low Pigment Density, Large Single-Photon 

Response, and High-Efficiency Transmission. Michael Tri H. Do, 

Shin H. Kang, Tian Xue, Haining Zhong, Hsi-Wen Liao, 

Dwight E. Bergles, King-Wai Yau. 

4:00 PM–6:00 PM, ROOM 252 A/B 

PLATFORM P 

Muscle: Molecular Mechanics and Sructure 

Co-Chairs: Yuri Nesmelov, University of Minnesota 

Jim Vigoreaux, University of Vermont 

1032-PLAT 4:00 PM 

Thermodynamics Of The Myosin Nucleotide-binding Pocket Measured By 

Epr Spectroscopy Using Spin Labeled Nucleotides. Thomas J. Purcell, 

Nariman Naber, Ed Pate, Roger Cooke. 

1033-PLAT 4:15 PM 

Transient Dynamics of the Force-Generating Domain in Myosin During 

the Recovery Stroke. Yuri E. Nesmelov, Roman V. Agafonov, 

Igor V. Negrashov, Sarah Blakely, Margaret A. Titus, David D. Thomas. 

1034-PLAT 4:30 PM 

Modeling The Mechanics and Enzymatic Activities of Doubly, Singly and 

Unphosphorylated Smooth Muscle Myosin. Sam Walcott, 

David M. Warshaw. 

1035-PLAT 4:45 PM 

Drug Effects and Mechanism Underlying the Force-velocity Relationship of 

Skeletal Muscle. Nuria Albet-Torres, Marieke J. Bloemink, Tom Barman, 

Robin Candau, Michael A. Geeves, Kerstin Golker, Christian Herrmann, 

Corinne Lionne, Claudia Piperio, Stefan Schmitz, Claudia Veigel, 

Alf Mansson. 

1036-PLAT 5:00 PM 

Role Of Myosin Binding Proteins On The Structural Stability And Flexural 

Rigidity Of Thick Filaments. Jim O. Vigoreaux, Lori Nyland, 

John Contompasis, Laurent Kreplak, David Maughan, Bradley Palmer. 

1037-PLAT 5:15 PM 

Thin Filament Regulation of Relaxation in 3D Multi-Sarcomere Geometry. 

Srboljub M. Mijailovich, Oliver Kayser-Herald, Richard L. Moss, 

Michael A. Geeves. 

1038-PLAT 5:30 PM 

Molecular Dynamics of Tropomyosin: Implications for the Assembly and 

Regulation of Thin Filaments. Xiaochuan Li, William Lehman, 

Kenneth C. Holmes, Stefan Fischer. 

1039-PLAT 5:45 PM 

Obscurin, A Large Modular Protein, Regulating Sarcomere Formation In 

Drosophila Muscle. Anja Katzemich, John Sparrow, Belinda Bullard. 

6:00 PM–7:00 PM, ROOM 253 A/B 

BIOPHYSICAL SOCIETY OF CANADA MIXER 

6:00 PM–8:00 PM, HALL A 

STUDENT RESEARCH ACHIEVEMENT AWARD 

(SRAA) POSTER COMPETITION 

This session features students who are presenting posters at the meeting and 

have indicated they wish to participate in the competition at the time of abstract 

submission. During the competition, students give a five-to-ten minute verbal 

presentation of their posters to one or more judges. Awardees are honored at the 

Monday evening Awards Ceremony. 


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7:30 PM–9:30 PM, BALLROOM EAST 

WORKSHOP 1 

Advanced Single Molecule Fluorescence 

Techniques in Vitro and in Vivo 

Chair: Jeff Gelles, Brandeis University 

1040-WKSHP 7:30 PM 

Single-Molecule Analysis of Transcription. 

Richard Ebright, Shimon Weiss, Anirban Chakraborty, Dongye Wang, 

You Korlann, Achillefs Kapanidis, Emmanuel Margeat. 

1041-WKSHP 7:55 PM 

In vitro and in vivo; kinesin and myosin moving one (or a few) at a time. 

Paul Selvin. 

1042-WKSHP 8:20 PM 

In-Vivo Super-Resolution Microscopy by Structured Illumination. 

Mats G. L. Gustafsson. 

1043-WKSHP 8:45 PM 

Advanced Fluorescence Microscopy Of Single, Living Cells: Using Optical 

Proteomics To Study Native Biochemistry One Molecule At A Time. 

Mark C. Leake. 

1044-WKSHP 9:10 PM 

Elucidating Mechanisms in Complex Systems by Multi-wavelength Singlemolecule 

Fluorescence. Jeff Gelles. 

7:30 PM–9:30 PM, BALLROOM WEST 

WORKSHOP 2 

Channelopathies of Nerve and Muscle 

Chair: Stephen Cannon, University of Texas Southwestern Medical Center at Dallas 

1045-WKSHP 7:30 PM 

Mechanistic Diversity for Channelopathies of Brain and Skeletal Muscle. 

Stephen C. Cannon. 

1046-WKSHP 7:55 PM 

Neuronal calcium channels and migraine. Daniela Pietrobon. 

1047-WKSHP 8:20 PM 

Presenilins Function as ER Calcium Leak Channels: Implications for 

Alzheimer’s Disease. Ilya Bezprozvanny. 

1048-WKSHP 8:45 PM 

Mutations in skeletal muscle. William A. Catterall. 

1049-WKSHP 9:10 PM 

Gating Pore Currents from S4 Mutations of NaV1.4: A Common 

Pathomechanism in Hypokalemic Periodic Paralysis. Arie Struyk, 

Stephen C. Cannon. 


7:30 PM–9:30 PM, ROOM 153 A/B 

WORKSHOP 3 

Enzymes in Energy Metabolism 

Chair: Michael Radermacher, University of Vermont 

1050-WKSHP 7:30 PM 

Enzymes in Energy Metabolism, Introduction. Michael Radermacher. 

1051-WKSHP 7:55 PM 

Organization and Structural Features of Phosphofructokinase and other 

Glycolytic Enzymes to Meet their Role in Energy Metabolism. 

Juan J. Aragón, Cristina Ferreras, Cristina Sánchez, Valentina Sánchez, Eloy 

D. Hernández, Carmen Hermida, Cristina Adan, Rafael Garesse, Oscar H. 

Martínez-Costa. 

1052-WKSHP 8:20 PM 

How Mitochondrial Structure Can Affect Energy Metabolism: Insights 

From Electron Microscopic Tomography. Carmen Mannella, 

Chyong-ere Hsieh, Karolyn Buttle, Christian Renken, Michael Marko. 

1053-WKSHP 8:45 PM 

Molecular Architecture of Pyruvate Dehydrogenase Complexes. 

Jacqueline Milne. 

1054-WKSHP 9:10 PM 

Electroneutral And Electrogenic Catalysis By Diheme-Containing 

Succinate:Quinone Oxidoreductases. C. Roy D. Lancaster. 

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1:00 PM–3:00 PM, HALL A 

SUNDAY POSTER SESSIONS 

Poster should be mounted at 6:00 PM on the day preceding presentation and removed by 5:30 PM on the day of the presentation. Posters will be on 

view until 10:00 PM the night before presentation. Abstract numbers shown refer to the program order of abstracts printed in the Abstracts Issue. 

Board Numbers indicate where they are located in Hall A. 

18 

ODD NUMBERED BOARDS 

1:00 PM–2:00 PM 

BOARD NUMBERS 

Board #B1–Board #B29 


Board #B60–Board #80 








































Authors Present 

EVEN NUMBERED BOARDS 

2:00 PM–3:00 PM 

POSTER CATEGORIES 

Emerging Single Molecule Techniques I 

Imaging & Optical Microscopy I 

Molecular Mechanics & Force Spectroscopy 

Molecular Simulations of Membranes & Membrane Proteins 

Fluorescence Spectroscopy I 

Micro & Nanotechnology 

Genome Packaging & Manipulation I 

Protein-Nucleic Acid Interactions I 

Protein Structure 

Protein Dynamics I 

Protein Assemblies 

Protein Folding & Stability I 

Molecular Recognition in Silico 

Protein Aggregates I 

Protein Aggregates II 

Lipids and Signaling on Membrane Surface 

IP3 Receptors 

Exocytosis & Endocytosis 

Endoplasmic Reticulum & Protein Trafficking 

Nucleocytoplasmic Transport 

Ryanodine Receptors Type I 

Ryanodine Receptors Type II 

Calcium Signaling Proteins 

Calcium Signaling Pathways 

Actin & Actin-binding Proteins 

Actin-binding Proteins in Physiology & Disease 

Cytoskeletal Protein Dynamics & Intracellular Cargo Transport 

Microtubular Motors I 

Unconventional Myosins 

Ion Motive ATPases 

Membrane Transport 

Membrane Dynamics & Bilayer Probes I 

Membrane Active Peptides I 

Membrane Active Peptides II 


Smooth & Skeletal Muscle Electrophysiology 

Acetylcholine Receptors 

Channel Regulation & Modulation 

Voltage-gated K Channels—Permeation 

Voltage-gated Ca Channels I 

Voltage-gated Ca Channels II 

Voltage-gated K Channels - Gating I 


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Emerging Single Molecule Techniques I 

(Boards #B1–#B29) 

122-POS BOARD #B1 

Single Molecule Immuno Pull Down Assay (SiMPull) for Studying Protein- 

Protein Interactions. Ankur Jain, Biswa Ramani, Kaushik Raghunathan, 

Prakrit Jena, Yang Xiang, Taekjip Ha. 


A Single-Molecule System for Detection and Quantification of Proteins with 

Robust Capture Units and Potential for High Multiplexing. 

Vyacheslav Papkov, Ying Wu, Ted Foss, Alicia L. Dow, Eric J. White, 

Nancy L. Pellerin, Natalia Mamaeva, Rudolf Gilmanshin, Randall E. Burton*. 


Binding Specificity of Multi-Labeled PNA Probes Studied by Single Molecule 

Mapping. Ekaterina Protozanova, Ting Wang, Kyoko Uehara, 

Misha Safranovitch, Rhea Mahabir, Jess Shen, Niru Chennagiri, 

Douglas B. Cameron, Rudolf Gilmanshin. 


High Resolution Imaging Via SHREC And SHRImP For Ultra-High 

DNA/RNA Resolution. Murat Baday, Ming Xiao, Han Cao, Paul Selvin. 


Dynamic Single-molecule Colocalization Imaging - A New Method For 

Examining Membrane Protein Association In Living Cells. James T. McColl, 

Ricardo Alexandre, John R. James, Paul D. Dunne, Ji Won Yoon, 

Simon J. Davis, David Klenerman. 

127-POS BOARD #B6 STUDENT TRAVEL AWARDEE 

Characterizing The Equilibrium Blinking Behavior Of Fluorogens 

With Fluorogen Activating Proteins (FAPs). Qi Yan, Suvrajit Maji, 

Marcel P. Bruchez. 


Single Molecule Anisotropy Imaging with Fluorescence Photoactivation 

Localization Microscopy. Travis J. Gould, Mudalige S. Gunewardene, Manasa 

V. Gudheti, Vladislav V. Verkhusha, Shu-Rong Yin, Julie A. Gosse, Samuel T. 

Hess. 


Fluorescence Correlation Spectroscopy In Live Bacillus Subtilis Cells: An In 

Vivo Study Of Transcriptional Regulation. Matthew L. Ferguson, 

Nathalie Declerck, Catherine A. Royer. 


Full Fluorescence Correlation Analysis - From Picoseconds To Seconds- For 

The Study Of Biomolecular Interactions And Dynamics. Samantha Fore, Felix 

Koberling, Michael Wahl, Thomas Huser, Sonny Ly, Ting Guo. 


Fluorescence Correlation Spectroscopy with Sub-Diffraction-Limited 

Resolution Using Near-field Optical Probes. Linda J. Johnston, 

Dusan Vobornik, Zhengfang Lu, Rod Taylor, Daniel Banks, Cecile Fradin. 


Single Molecule Lifetime Probability Distribution Analysis (t-PDA). 

Matthew Antonik. 


FCS and Sub-diffraction Resolution Fluorescence Imaging of Membrane 

Receptors in Living Organelles. Stephanie Grabowski, Stefan Marawske, 

Stanislav Kalinin, Ralf Kühnemuth, Stefanie Weidtkamp-Peters, 

Andrea Bleckmann, Yvonne Stahl, Rüdiger Simon, Claus Seidel. 

134-POS BOARD #B13 SRAA POSTER 

Single molecule image deconvolution. I. Standard deviation analysis of immobile 

fluorescent molecules. Michael C. DeSantis, Shawn DeCenzo, 

Yan Mei Wang. 


EstimationTool And FandPLimittool - User-friendly Software Packages For 

Single Molecule Localization/Resolution And Accuracy Calculations. 

Anish V. Abraham, Sripad Ram, Jerry Chao, E. S. Ward, Raimund J. Ober. 


Maximum-Likelihood Position Sensing of Single Molecules in a Confocal 

Microscope. Lloyd M. Davis, James A. Germann, William N. Robinson, 

Brian K. Canfield. 


Quantitative Study Of Single Molecule Localization Techniques. 

Anish V. Abraham, Sripad Ram, Jerry Chao, E. Sally Ward, 

Raimund J. Ober. 



Creation and Mixing of Monodisperse Sub-femtoliter Bioreactors. 

Jianyong Tang, Ana M. Jofre, Rani B. Kishore, Joseph E. Reiner, 

Mark E. Greene, Geoffrey M. Lowman, John S. Denker, Christina Willis, 

Kristian Helmerson, Lori S. Goldner. 


Simultaneous Measurement Of Ionic Current And Fluorescence From Single 

Protein Pores. Andrew J. Heron, James R. Thompson, Brid Cronin, 

Hagan Bayley, Mark I. Wallace. 


Laser Induced Popcorn-like Conformational Transition of Nano-diamond as a 

Nanoknife. Chia-Ching Chang, Hsueh-Liang Chu, Tzu-Cheng Lee, 

Ching-Chung Chou. 


High throughput Single-Molecule Spectroscopy Using Nanoporous 

Membranes. Joshua Edel, Guillaume Chansin. 


Using Nanomaterials to Probe Rotation of Individual Cell Surface Receptors. 

Shaorui Xu, Peter W. Winter, Deborah A. Roess, B. George Barisas. 


Manipulating The Environment Of a Single Lipase Molecule. 

Li Wei, Nikos Hatzakis, Sune K. Jørgensen, Per Hedegård, 

Dimitrios Stamou. 


Single Molecule Studies of the Interactions between b-Amyloid 1–40 and 

Supported Planar Lipid Membrane. Hao Ding, Joseph A. Schauete, 

Duncan G. Steel, Ari Gafni. 


Single-Molecule Imaging of AMPA and Nicotinic Acetylcholine Receptors in 

Mammalian Cells. Paul D. Simonson, John Alexander, Okunola Jeyifous, 

William N. Green, Paul R. Selvin. 


Single-molecule Imaging of ATP-driven Stepping Rotation of FoF1-ATP 

Synthase Reconstituted into Supported Membrane. Ryota Iino, 

Khek-Chian Tham, Kazuhito V. Tabata, Hiroshi Ueno, Hiroyuki Noji. 


How is the Temperature Sensitive (TS) Reaction of F1-ATPase Coupled with 

its Rotation? Sawako Enoki, Ryota Iino, Rikiya Watanabe, Hiroyuki Noji. 


Towards A New Generation Of Single Molecule High Resolution Sensors. 

Francoise Argoul, Nicolas Hugo, Thibault Roland, Pascale Milani, 

Audrey Fahys, Lotfi Berguiga, Juan Elezgaray, Zofia Haftek, Alain Arneodo. 


Cooperative Three-step Motions In Catalytic Subunits of F1-ATPase Drive 80° 

And 40° Substep Rotations. Takayuki Nishizaka, Tomoko Masaike. 


Investigating the Efficacy of Peptide-based Inhibitors Against the Earliest 

Oligomers of Amyloid-b Peptide. Robin K. Lammi, Lyndsey R. Powell, 

Kyle D. Dukes, Cyrus K. Bett, Marcus A. Etienne, Robert P. Hammer. 

Imaging & Optical Microscopy I (Boards #B30–#B59) 


BioTIFF: A New BigTIFF File Structure For Organizing Large Image Datasets 

And Their Associated Metadata. Peter S. Pennefather, West Suhanic. 


Virtual FRAP - an Experiment-Oriented Simulation Tool. James C. Schaff, 

Ann E. Cowan, Leslie M. Loew, Ion I. Moraru. 


Live Cell Imaging: Tips and Tools. Melanie M. Frigault, Judith Lacoste, 

Jody L. Swift, Claire M. Brown. 


Chondrocytes Deformation In The Live Mouse Knee. Ziad Abusara, 

Ruth Seerattan, Robert Thompson, Walter Herzog. 


Protein Diffusion in the E. coli Cytoplasm and Periplasm under Osmotic 

Stress. James C. Weisshaar, Michael C. Konopka, Kem A. Sochacki, 

Benjamin P. Bratton, Colin Ingram. 

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Measuring the Number of LuxR Proteins in a Single Cell of V. harveyi. 

Shu-Wen Teng, Yufang Wang, Kim Tu, Tao Long, Ned Wingreen, 

Bonnie L. Bassler, Phuan N. Ong. 


Influence Of P-selectin Structure On Its Mobility In The Weibel-Palade Body 

And Plasma Membranes. Gregory Mashanov, Nikolai Kiskin, Nicola Helen, 

Victor Babich, Laura Knipe, Justin Molloy, Matthew Hannah, Tom Carter. 


Quantitative Analysis of Spatial Protein-protein Proximity in Fluorescence 

Confocal Microscopy. Yong Wu, Yi-Kuang Liu, Mansoureh Eghbali, 

Enrico Stefani. 


The White Confocal - Controlling Spectral Fluorescence. Rolf T. 

Borlinghaus. 


Identifying Components Of Astroglial Autofluorescence Using The Spectral 

Separability Index, Xijk. Dan Zhu, Sébastien Nicoulaud, Christina Kleinert, 

Nicholas Benech, Dongdong Li, Nicole Ropert, Martin Oheim. 


Combinatorial Labeling And Spectral Imaging, (CLASI): A Method To 

Greatly Expand The Number of Distinguishable Fluorescent Labels in a Single 

Image. Alex M. Valm, Jessica L. Mark Welch, Christopher W. Rieken, 

Yuko Hasegawa, Rudolf Oldenbourg, Gary G. Borisy. 


Blind Source Separation Techniques For The Decomposition Of Multiply 

Labeled Fluorescence Images. Richard A. Neher, Misˇo Mitkovski, 

Frank Kirchhoff, Erwin Neher, Fabian J. Theis, André Zeug. 


A Theory Facilitating the Investigation of Sub-resolution Membrane 

Trafficking Using Total Internal Reflection Fluorescence Microscopy. 

Shaohui Huang, Lawrence Lifshitz, Karl Bellve, Clive Standley, Kevin Fogarty, 

Michael Czech. 


Expanding The Applicability Of The Multi-photon Fluorescence Recovery 

After Photobleaching Technique In Vivo Using A New Convective Flow 

Model. Kelley D. Sullivan. 


Diffusion and Exchange of Non-Integral Membrane Associated Fluorophores 

During Fluorescence Recovery After Photobleaching with the Confocal Laser 

Scanning Microscope: ROI Size Analysis of EGFP:Ras2 Plasma Membrane 

Diffusion in Saccharomyces cerevisiae. Kalyan C. Vinnakota, David Mitchell, 

Robert J. Deschenes, Tetsuro Wakatsuki, Daniel A. Beard. 


Dynamic Spatial Distribution of RNA Polymerase in Live E. coli. 

Benjamin P. Bratton, M T. Record, James C. Weisshaar. 


Morphogen Gradient Formation Unraveled Using In Vivo Three-dimensional 

Single Molecule Microscopy. Laurent Holtzer, Anna Kicheva, 

Marcos Gonzalez-Gaitan, Thomas Schmidt. 


Gaq Binds Two Effectors Independently in Cells: Evidence for Pre-determined 

Pathways. Urszula P. Golebiewska, Suzanne Scarlata. 


Trafficking Of Glutamatergic And Peptidergic Vesicles In Astrocytes. 

Robert Zorec, Matja Stenovec, Maja Potokar, Marko Kreft, 

Mateja Erdani Kreft. 


Developing Statistical Diagnostic Tools For Discriminating Between Different 

Diffusive Modes Of Fluorescently Tagged Protein Complexes In Living Cells 

For Short Duration Trajectories. Alex Robson, Marcus Tyndall, Philip Maini, 

Mark C. Leake. 


Probing the Intracellular Reaction Dynamics of Low Density Lipoprotein 

Using Single Particle Tracking Fluorescence Microscopy. 

William H. Humphries IV, Christine K. Payne. 


Activation Pathway Of paGFP In Living Cells. Ilaria Testa, Davide Mazza, 

Mario Faretta, Alberto Diaspro. 

20 


Organelle Specific Associations of HIV-1 Nef with HLA-I A2 and CD4 using 

Fluorescence Cross Correlation Spectroscopy. Tilman Rosales, Ling Yi, 

Jay R. Knutson, Sundararajan Venkatesan. 


Raster Image Correlation Spectroscopy (RICS) with One Photon Excitation 

and Analog Detection: Some Practical Considerations for GUVs and Cell 

Membranes. M vandeVen, E. Gielen, B. De Clercq, N. Smisdom, 

M. Ameloot. 


Effects of Oversampling and Scanning Artifacts on the Accuracy of Spatial 

Fluorescence Intensity Fluctuation Analysis Methods. Mikhail Sergeev, 

Antoine G. Godin, Jody L. Swift, Yves De Koninck, Paul W. Wiseman. 


Biocompatible Quantum Dots for Intravital Kidney Imaging. Pu Wang, 

Daniel E. Minner, Keith M. Stantz, Christoph Naumann, Weiming Yu. 


Time-lapse Imaging of Individual BKCa Channels in Live Cells Using 

Site-specific Labeling of Quantum Dots. Ji-Yeon Kim, Haedeun Kim, 

Sungho Chang, Chul-Seung Park. 


Non-Invasive Pyrenebutyrate-mediated Delivery of Quantum Dots to the 

Cytosol of Living Cells. Amy E. Jablonski, Christine K. Payne. 


Characterizing the Architecture of Nicotinic Receptors with Quantum Dot- 

Based Fluorescence Microscopy. Rigo Pantoja, Erik A. Rodriguez, Shelly Tzlil, 

Larry Wade, Dennis A. Dougherty, Henry A. Lester. 


HIV-virions Appear To Be Trapped By Human Cervical Mucus. 

Hacene Boukari, Beda Brichacek, Leonid Margolis, Ralph Nossal. 

Molecular Mechanics & Force Spectroscopy 

(Boards #B60–#B80) 


Nucleosome Stacking Defines The Structural And Mechanical Properites Of 

Chromatin Fibers. Fan-Tso Chien, Maarten Kruithof, Andrew Routh, 

Daniela Rhodes, John van Noort. 


Mechanism Of DNA Translocation By SpoIIIE/Ftsk. Marcelo Nollmann, 

Jerod Ptacin, Eric Becker, Kit Pogliano, Carlos Bustamante. 


VirE2: A Unique ssDNA-Compacting Molecular Machine. Martin Hegner, 

Wilfried Grange, Sudhir Husale, Myriam Duckely. 


Experimental Evidence Of Polymer Hydrophobic Collapse Due To Water 

Density Fluctuation. Isaac T.S. Li, Nikhil Gunari, Gilbert C. Walker. 


Non-ideal Elasticity Of Single Stranded DNA At Low Forces. 

Dustin McIntosh, Omar Saleh, Phil Pincus, Noah Ribeck. 


Single Molecule Force Spectroscopy of Guanine Quadruplex DNA. 

Susanna Lynch, Heather Baker, Sarah Byker, Dejian Zhou, Kumar Sinniah. 


Kalman Filter Estimates of the Contour Length of an Unfolding Protein in 

Single-Molecule Force Spectroscopy Experiments. Vicente I. Fernandez, 

Pallav Kosuri, Vicente Parot, Julio M. Fernandez. 


Unfolding, refolding and proteolysis of the von Willebrand Factor A2 domain 

under tensile force. Xiaohui Zhang, Kenneth Halvorsen, Wesley P. Wong, 

Timothy A. Springer. 


The Temperature Dependency of Disulfide Bond Reduction Events 

Measured by Single-molecule Force Clamp Spectroscopy. Jian Liang, 

Julio M. Fernandez. 


Direct Identification of Two Distinct Transition State Structures in Reduction 

of a Disulfide Bond Revealed by Single Bond Force-clamp Spectroscopy. 

Sergi Garcia-Manyes, Jian Liang, Julio M. Fernandez. 



Nebulin Elasticity Pre-loads Thin Filaments of Skeletal Muscle: Unfolding of 

Transient a-helices. Jeffrey G. Forbes, Vamsi K. Yadavali, Wanxia L. Tsai, 

Kuan Wang. 


Effects of Cantilever Stiffness on Unfolding Force in AFM Protein Unfolding. 

William T. King, Guoliang Yang. 


E-selectin/sLea Form Catch-Slip Bonds Without Force-History Dependence. 

Jeremy H. Snook, William H. Guilford. 


How Protein Materials Balance Strength, Robustness And Adaptability. 

Markus J. Buehler, Sinan Keten, Theodor Ackbarow, Jérémie Bertaud. 


Single-Molecule Mechanics of the Muscle Protein Myomesin. 

Felix Berkemeier, Matthias Rief. 


Bending rigidity of type I collagen homotrimer fibrils. Sejin Han, 

Charlotte Phillips, Daniel McBride, Robert Visse, Hideaki Nagase, 

Wolfgang Losert, Sergey Leikin. 


AFM Manipulation Of Small Fibrin Networks. Nathan E. Hudson, 

Daniel C. Millard, John Houser, E. Timothy O’Brien, Susan T. Lord, 

Richard Superfine, Michael R. Falvo. 


Probing Structure and Mechanics of Yeast Prion Proteins with Optical 

Tweezers. Carlos E. Castro, Jijun Dong, Mary Boyce, Susan Lindquist, 

Matt Lang. 


Dwell Time And Maximum Likelihood Analysis Of Single Molecule Disulfide 

Bond Reduction Events While Under A Stretching Force. 

Robert Szoszkiewicz, Lorin Milescu, Julio M. Fernandez. 


Intrinsically Disordered Titin PEVK as a Molecular Velcro: Salt-Bridge 

Dynamics and Elasticity. Jeffrey G. Forbes, Wanxia L. Tsai, 

Richard J. Wittebort, Kuan Wang. 


AFM Mechanical Studies Of A Novel Form Of The Biopolymer Fibrin: 

Elastomeric Sheets. Michael R. Falvo, Nathan Hudson, Daniel C. Millard, 

E Timothy O’Brien III, Richard Superfine. 

Molecular Simulations of Membranes & Membrane 

Proteins (Boards #B81–#B95) 


Substrate translocation pathway in glutamate transporter: Insights from 

molecular simulations. Yan Gu, Indira H. Shrivastava, Susan G. Amara, 

Ivet Bahar. 


Interaction of Novel Ibogaine Analogs With The Human a3b4 Nicotinic 

Receptor. Benjamin P. Coleman, Samira Sarrami, Hugo R. Arias. 


Noble Gas Anesthetics and Immobilizers Show Different Binding Distributions 

to KcsA Channel. Masayuki Ozaki, Tomoyoshi Seto. 


Ligand Induced Conformational Changes in GPCRs: Insight Into the 

Activation of Rhodopsin and b-adrenergic Receptors. Supriyo Bhattacharya, 

Nagarajan Vaidehi. 


Structural Determinants Of Antibiotic And b-lactamase Diffusion Through 

Bacterial Porins. Amit Kumar, Eric Hajjar, Paolo Ruggerone, 

Matteo Ceccarelli. 


Conformational Transitions and Proton Conduction in the Multidrug Efflux 

Pump AcrB. Nadine Fischer, Christian Kandt. 


Dynamics Of Water Molecules In Bacteriorhodopsin Mutants. 

Mihnea Dulea, Ana-Nicoleta Bondar. 



The Biophysics Of Antibiotics Translocation Through OmpF Revealed By 

Computer Simulations. Eric Hajjar, Amit Kumar, Enrico Spiga, 

Jean-Marie Pages, Kozhinjampara Mahendran, Tivadar Mach, 

Andrey Bessonov, Mathias Winterhalter, Paolo Ruggerone, Matteo Ceccarelli. 


Simulation Studies Of Trace Amines Passing Through Neuronal Membranes. 

Bruno L. Tomberli, Jarrod Nickel, Mark Berry. 


All-atom Molecular Dynamics Simulations of a Membrane Protein Stabilizing 

Polymer. William J. Drasler, Jonathan N. Sachs. 


Electroporation Sensitivity of Oxidized Phospholipid Bilayers. 

Zachary A. Levine, Yu-Hsuan Wu, Matthew J. Ziegler, D. Peter Tieleman, 

P. Thomas Vernier. 


CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to 

Yeast Membranes. Sunhwan Jo, Jeffery B. Klauda, Wonpil Im. 


Conformational Analysis and Molecular Dynamics Study: 2-Arachidonoylsn-glycero-3-phosphoinositol 

(2-AGPI) in a DOPC Bilayer. 

Evangelia Kotsikorou, Diane Lynch, Patricia Reggio. 


A Novel Analysis Technique For Determining Area Per Lipid And Electron 

Density Profiles From Large Lipid Bilayer Molecular Dynamics Simulations. 

Anthony R. Braun. 


Undriven Bead Diffusion Through Extracellular Matrix. Zachary Hackney, 

Lamar Mair, Richard Superfine. 

Fluorescence Spectroscopy I (Boards #B96–#B122) 


Image Correlation Spectroscopy Reveals Global Dynamics of Wound Healing. 

Kandice Tanner, Donald Ferris, Luca Lanzano, Berhan Mandefro, William 

W. Mantulin, David Gardiner, Elizabeth Rugg, Enrico Gratton. 


Studying Molecular Dynamics And Interactions In Living Zebrafish Embryos 

By Fluorescence Correlation Spectroscopy. Xianke Shi, Yong Hwee Foo, 

Shang Wei Chong, Vladimir Korzh, Thankiah Sudhaharan, Sohail Ahmed, 

Thorsten Wohland. 


Applicability Of An EM-CCD For Spatially Resolved TIR-FCS. 

Daniel Boening, Teja Wolfgang Groemer, Jurgen Klingauf. 


Imaging Total Internal reflection - Fluorescence Cross-correlation Spectroscopy 

(ITIR-FCCS). Jagadish Sankaran, Lin Guo, Thorsten Wohland. 


Analysis Of Diffusion And Binding In Cells Using The Rics Approach. 

Enrico Gratton, Michelle A. Digman. 


Effect of Multiple Scattering on the Illumination Profile in Fluorescence 

Correlation Microscopy. Jason Riley, Ralph Nossal, Amir Gandjbakhche, 

Hacene Boukari. 


Characterizing Protein Interactions In Different Cellular Compartments By 

Axial Scan Fluorescence Fluctuation Spectroscopy. Yun Chen, Yan Chen, 

Joachim Mueller. 


The Study of Interaction of Hypericin And Its Pharmaceutical Preparation by 

Fluorescence Techniques. Jun Liu, Constance Lay Lay Saw, Malini Olivo, 

Thankiah Sudhaharan, Sohail Ahmed, Paul Wan Sia Heng, 

Thorsten Wohland. 


Brightness Analysis of Nuclear Receptor Interactions in a Cell-Free Expression 

System. Patrick J. Macdonald, Jolene Johnson, Yan Chen, Bin Wu, 

Joachim Mueller. 


Resolvability of PCH in Two Dimensional Systems. Yu Li, Bill 

McConnaughey, Yanxin Liu, Guy Genin, Elliot Elson. 

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Insights Into The Microscopic Origin Of Anomalous Diffusion From 

Crowded Solutions. Jedrzej Szymanski, Matthias Weiss. 


Bacterial Sec Protein Transport is Rate-limited by Precursor Length: A Single 

Turnover Study. Fucheng Liang, Umesh Bageshwar, Siegfried Musser. 


Single Molecule FRET Measurements of Dye-labeled DNA. 

Nicolas Di Fiori, Amit Meller. 


Structural Dynamics of SERCA and Phospholamban by Fluorescence and 

Phosphorescence. Ji Li, David D. Thomas. 


Single molecule measurements of ATP-myosin V and ADP-myosin V. 

Shira Stav, Ana Jofre. 


Fluorescence Labeling And Purification Of Cellulases For Single Molecule 

Spectroscopy. Jose M. Moran-Mirabal, Stephane C. Corgie, 

Jacob C. Bolewski, Hanna M. Smith, Larry P. Walker. 


Metal-Enhanced Fluorescence (MEF). Yongxia Zhang, Kadir Aslan, 

Chris D. Geddes. 


Action-Spectra of Electrochromic Voltage-Sensitive Dyes in an Intact Excitable 

Tissue. Joseph Foley, Martin Muschol. 


Plasmonic Electricity: A Digital form of Metal-Enhanced Fluorescence. 

Anatoliy Dragan, Chris D. Geddes. 


Ultrafast Decay of Trp in Biological Macromolecules. Jianhua Xu, 

Olga Tcherkasskaya, Angela M. Gronenborn, Patrik Callis, Dmitri Toptygin, 

Florence K. Gleason, Ludwig Brand, Jay R. Knutson. 


Rapid Detection of Troponin I from Serum using Microwave-Accelerated 

Metal-Enhanced Fluorescence. Kadir Aslan, Yongxia Zhang, 

Chris D. Geddes. 


Structural and Mechanistic Characterization of the Mannitol Transporter from 

E. coli using 5-fluorotryptophan as a Spectroscopic Probe. Milena Opacic, 

Ben H. Hesp, Jaap Broos. 


Investigation Of Excited-State Relaxation In Single-Tryptophan- And Other 

Proteins Via Multidimensional Static And Time-Resolved Fluorescence. 

Stefanie Schwedler, Katharina Kohse-Höinghaus, Regina Brockhinke, Andreas 

Brockhinke. 


The g-Crystallin Fold May Have Evolved To Protect Conserved Tryptophan 

Residues From UV Radiation Damage Through Efficient Quenching. 

Jiejin Chen, Patrik R. Callis, Jonathan King. 


Mapping Proximity Within Proteins Using Fluorescence Spectroscopy: New 

Advances In Distance-dependent Tryptophan-induced Fluorescence 

Quenching. Steven E. Mansoor, Mark A. DeWitt, David L. Farrens. 


Mutations In Transhydrogenase Change The Fluorescence Emission State Of 

Trp72 From La To Lb. Jaap Broos, Karina Tveen Jensen, 

Giovanni B. Strambini, Margherita Gonelli, Baz Jackson. 


MD Simulations of the Time-Dependent Red Shift in the Fluorescence of Trp 

in Protein GB1. Dmitri Toptygin, Thomas B. Woolf, Ludwig Brand. 

Micro & Nanotechnology (Boards #B123–#B152) 


An Integrated Multifunctional Lab-on-a-Chip Platform for High Throughput 

Optical Mapping of DNA. Lisa W. Kwok, Yi Zhou, Bryan Crane, 

Linda Knaian, Kedar V. Vyavahare, Robert H. Meltzer, Joshua Griffis, Amanda 

Edmonson, Qun Zhong, Richard Allen, Wolf Mesadieu, 

Jonathan W. Larson, Jeffrey R. Krogmeier, Rudolf Gilmanshin. 

22 


Development Of A Cell Sorting Device Based On The Integration Of Porous 

Poly(dimethylsiloxane) (pdms) Membranes Into Layered Microfluidic Devices. 

Bor-han Chueh. 


3-D Microfluidic Technique for Patterning Cells. Jennifer H. Hou, 

Adam E. Cohen. 


The Toxic Effects of Quantum Dots on Embryogenesis in Caenorhabditis 

elegans. Shyemaa Shehata, Cecile Fradin. 


Collaboratory for Structural Nanobiology (CSN), Nanoparticles Database. 

Alvaro Gonzalez, Fernando D. Gonzalez-Nilo, Raul Cachau. 


A Nano-assay To Measure Modification Of Cysteine Residues In GST-fusion 

Proteins. Dixon J. Woodbury, Chris A. Rees, Ammon M. Thompson, 

Paul Meiners, J. Scott Bluth. 


A Microfluidic Platform for the Culture & Analysis of Single Cells. 

Eric Hall, Samuel Kim, Richard N. Zare. 


A Pulse Width Modulated Microfluidic Diluter. Alar Ainla, Aldo Jesorka, 

Owe Orwar. 


Controlled Near Infrared Laser-Activated Liposome Release. Guohui Wu, 

Claudia Gottstein, Alexander Mikhailovsky, Htet A. Khant, 

Joseph A. Zasadzinski. 


The Collaboratory for Structural Nanobiology. Alvaro M. Gonzalez-Ibanez, 

Fernando Gonzalez-Nilo, Raul Cachau. 


Tunable Delivery Of Chemical Gradients Over Large Cell Culture Substrates 

Using Microfluidic Stacked Flows. Christopher G. Sip, Albert Folch, 

Hoyin LAI. 


Detection and Identification of Virus Particles on a Microfluidic Platform. 

Louis Strong, Clark Edson, Daniel B. Hall, Senerath Palamakumbura, 

Gyula Varadi. 


Phenotypic and Genotypic Heterogeneity of Cyanobacterial Populations in 

Hot Spring Microbial Mats Revealed by Microfluidic Single-Cell Analysis. 

Samuel Kim, Eric Hall, Bor-han Chueh, Richard N. Zare. 


Adsorption and Stability of Streptavidin on Cluster-Assembled Nanostructured 

TiOx Films. Pasquale Emanuele Scopelliti, Luca Giorgetti, Gero Bongiorno, 

Alessandro Podestà, Giuseppe Berlanda, Roberta Carbone, Paolo Milani. 


A “Microfluidic Nose”: Detection of Olfactory Sensory Neuron Responses to 

Odorants Across the Whole Olfactory Receptor Space. Albert Folch, 

Xavier A. Figueroa, Gregory A. Cooksey, Scott V. Votaw, Lisa Horowitz. 


SOI Nanofet Devices For Ultra-Sensitive Detection of Biomolecules. 

Bobby Reddy, Jr., Oguz H. Elibol, Brian R. Dorvel, Pradeep R. Nair, 

Muhammad A. Alam, Rashid Bashir. 


Molecular Scale Dielectric Sensors for Highly Sensitive Biomolecular Detection. 

Manu Sebastian Mannoor, Teena James, Dentcho V. Ivanov, 

William Braunlin, Les Beadling. 


Miniaturized Ion Channel Reconstitution Platform Based On Silicon 

Microfabrication. Michael Goryll, Nipun Chaplot. 


Rapid Incorporation of Heterologously Expressed GPCR CCR5 in Nanoscale 

Apolipoprotein Bound Bilayers (NABBs). Sourabh Banerjee, Amy Grunbeck, 

Thomas Huber, Pallavi Sachdev, Thomas P. Sakmar. 


Nanotubes As Drug Delivery Systems For Prokaryotic And Eukaryotic Cells. 

Sonia Antoranz Contera, Sonia Trigueros, J.F. Ryan. 


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Engineering the protein-nanoparticle interface. Kimberly Hamad-Schifferli. 


Combining Microfluidics, Electrophysiology, and Fluorescence Detection to 

Study Drug Transport Across Biomembranes. Kim Horger, Marian Adamson, 

Divya Rao, Michael Mayer. 


A Realistic Model For The Water-amorphous Silica Interface: Insights Into The 

Electrical Double Layer And Bioengineering Applications. Ali Hassanali, 

Hui Zhang, Yun Kyung Shin, Chris Knight, Sherwin J. Singer. 


1-d Lipid Bilayers On Nanotube And Nanowire Templates: Properties And 

Device Applications. Nipun Misra, Julio Martinez, Shih-Chie Jay Huang, 

Pieter Stroeve, J. Woody Ju, Costas Grigoropoulos, Aleksandr Noy. 


Examining the Role of Neuregulin-1 in Synaptogenesis Using Microfluidics. 

Aileen J. Wu, Samir Koirala, Gabriel Corfas, Albert Folch. 


A Simulation Study of Carbon Nanotube Interactions with Designed 

Amphiphilic Peptides. E. Jayne Wallace, Robert S. G. D’Rozario, 

Beatrice Mendoza, Mark S. P. Sansom. 


Interaction of Fullerol C60(OH)20 with Nucleic Acids. Sini Anttalainen, 

Tatsiana Ratnikova, Pu-Chun Ke, Emppu Salonen. 


A Microdevice To Indicate Human Neural Stem Cell Differentiation Potential. 

Fatima H. Labeed, Jente Lu, Steve A. Marchenko, Kai F. Hoettges, 

Michael P. Hughes, Edwin S. Monuki, Abraham P. Lee, Lisa A. Flanagan. 


A Spectroscopic Monitoring Module Based on a Ceramic Microfluidic 

Platform. Erwin Gaubitzer, Bruno Balluch, Ibrahim Atassi, Walter Semtana, 

Gottfried Koehler. 


Dynamics of Calcitriol Uptake and Signaling using Conjugated Quantum 

Dots. Jeremy Bonor, Beth Bragdon, Betty Ingraham, Anja Nohe. 

Genome Packaging & Manipulation I 

(Boards #B153–#B182) 


The Role of Electrostatics in Sequence Dependent Nucleosome Stability 

Analysis. Thomas C. Bishop, Yuriy V. Sereda, Sergei Y. Ponomarev. 


Laser Microbeam-induced Spatiotemporal Change in Refractive Index of 

Chromosomes in Living PTK2 Cells. Suzanne L. Genc, 

Samarendra Mohanty, Lingfeng Yu, Michael W. Berns. 


Photonic and Magnetic Force Micro-piston: An integrated force/microfluidic 

device for investigating expansion and compression stress in chromatin/chromosomes 

and their roles in chromosome function. Jay K. Fisher, 

Romain Koszul, Mara Prentiss, Nancy Kleckner. 


Counterion Induced Electrostatic Condensation Of Nucleosomes And 

Chromatin Arrays. Lars Nordenskiöld, Abdollah Allahverdi, 

Nikolay Berezhnoy, Nikolay Korolev, Ying Liu, Chenning Lu, 

Alexander P. Lyubartsev, Ye Yang. 


A Course Grain Model of Histones and DNA in the Nucleosome. 

Thomas C. Bishop, Apostol Gramada, Sachin Goyal. 


Quantitative Model and Analysis of Nucleosome Organization near the 

Transcription Start Site in Yeast. Wolfram Mobius, Ulrich Gerland. 


Effect of Histone Acetylation on Nucleosome Dynamics Revealed by spFRET 

Microscopy. Ruth Buning, Wiepke J. A. Koopmans, Heinz Neumann, 

Jason W. Chin, Thomas Schmidt, John van Noort. 


Computer simulations of chromatin fibers. René Stehr, Nick Kepper, Ramona 

Ettig, Karsten Rippe, Gero Wedemann. 



Nanomanipulation Of Single Chromatin Fiber With Magnetic Tweezers. 

Pierre RECOUVREUX, Christophe Lavelle, Natalia Conde e Silva, Maria 

Barbi, Eric Le Cam, Ariel Prunell, Jean-Marc Victor, 

Jean-Louis Viovy. 


Rapid-Quench Mixing and Use of Fast Footprinting to Characterize DNA 

Opening in the Late Steps of Open Complex Formation at lPR by E. coli 

RNA Polymerase. Theodore J. Gries, Wayne S. Kontur, Michael W. Capp, 

Caroline A. Davis, Amanda C. Drennan, Ruth M. Saecker, M. 

Thomas Record, Jr. 


Stress, Scrunching And Tethering: The Roles Of The Connecting Template 

Strand In Initiation By T7 RNA Polymerase. Ankit Vahia, Craig T. Martin. 


Prevention Of Backtracking Alleviates Nucleosomal Barrier To Transcription. 

Jing Jin, Lu Bai, Daniel S. Johnson, Maria L. Kireeva, Mikhail Kashlev, 

Michelle D. Wang. 


Monte Carlo simulation of transcriptional control in 6kbp DNA. 

Naoko Tokuda, Masaki Sasai, George Chikenji. 


Investigating The Structural Dynamics Of The Lict Transcriptional 

Antiterminator And Its RNA Target By Single Molecule FRET. 

Matthew L. Ferguson, Caroline Clerté, Emmanuel Margeat, 

Nathalie Declerck, Catherine A. Royer. 


Characterization of The Open Complex of Yeast Mitochondrial RNA 

Polymerase. Guo-Qing Tang, Swaroopa Paratkar, Smita S. Patel. 


Characterizing the Effects of Highly Bent DNA on Transcription. 

Troy A. Lionberger, Edgar Meyhofer. 


Modulation Of Sequence-dependent Pausing Of Rna Polymerase By The 

Accessory Factor Nusa: A Single-molecule Study. Jing Zhou, Kook Sun Ha, 

Arthur La Porta, Robert Landick, Steven M. Block. 


SRAA POSTER 

Human TBP Bending of DNA Measured at the Single Molecule Level. 

Amanda E. Carpenter, Aaron R. Hieb, Meredith D. Betterton, 

James A. Goodrich, Thomas T. Perkins. 


Mechanics of Transcription Elongation Through The Nucleosome Using 

Single-Molecule and Biochemical Methods. Pooja Gupta, Miroslav Tomschik, 

Andrey Revyakin, Jordanka Zlatanova. 


Regulation of Transcriptional Activity of Estrogen Receptor Alpha by Novel 

Splice Variants. Pallob Kundu, Rong Lu, Enrico Stefani, Ligia Toro. 


Modeling Transcription Initiation By Bacterial RNA Polymerase. 

Marko Djordjevic. 


Probing The Structure And Function Of Transcription Complex Of Rna 

Polymerase Ii With Tfiif At Single Molecular Level. Wei-hau Chang. 


Agaerye. Timothee Lionnet, Jeffrey A. Chao, Yaron Shav-Tal, Xavier Darzacq, 

Robert H. Singer. 


Metal Preference At The Second Metal Binding Site Of E. coli NikR. 

Christine M. Phillips, Paul S. Nerenberg, Catherine L. Drennan, 

Collin M. Stultz. 


Force-Dependence of Lac-Repressor Mediated DNA Loop Formation. 

Yih-Fan Chen, Gerhard Blab, David P. Wilson, Jens-Christian Meiners. 


Malleable machines in transcription regulation: the Mediator complex. 

Ágnes Tóth-Petróczy, István Simon, Christopher Oldfield, 

Yuichiro Takagi, Keith Dunker, Vladimir Uversky, Monika Fuxreiter. 

23 

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Structure/function Correlations in P. aeruginosa DNA Ligase LigD. 

Aswin Natarajan, Hui Zhu, Pravin A. Nair, Stewart Shuman, Ranajeet Ghose. 


Zero-Mode Waveguides for Real-Time Observation of Single Nucleotide 

Incorporation. Zhuangxiong Huang, Serge Donkers, 

Jacob W.J. Kerssemakers, Nynke H. Dekker. 


Formation Of RecA Filament During The Mechanical Unzipping Of dsDNA 

To ssDNA: Competition With SSB Differentially Controls Reca Mediated Sos 

Response And Replication Repair. Carlo Zambonelli, Claudia Danilowicz, 

Nancy Kleckner, Mara Prentiss. 


Control of DNA Replication by Anomalous Reaction-Diffusion Kinetics. 

Michel G. Gauthier, John Bechhoefer. 

Protein-Nucleic Acid Interactions I 

(Boards #B183–#B210) 


Single-molecule Study of Site-specific DNA Recombination by gdResolvase. 

Mingxuan Sun, Hua Bai, Nigel D. Grindley, John F. Marko. 


Thermodynamics of Interactions between Histone-like Proteins from 

Escherichia coli (HU and IHF) and Intact Duplex DNA. Junseock Koh, 

Ruth M. Saecker, M. Thomas Record Jr. 


Novel Techniques for Study of the Nucleosome Core Particle Ionic 

Atmosphere and Its Role in Electrostatically-Driven DNA Packing. 

Kurt Andresen. 


Stress-Activated Sliding Motion: A Coupled-Potential Model. 

Caroline J. Ritz-Gold. 


High Resolution Surface Plasmon Microscopy: From Nano-colloids To Single 

Nucleosome Imaging. Thibault ROLAND, Lotfi Berguiga, 

Audrey Fahys, Zofia Haftek, Pascale Milani, Nicolas Hugo, 

Philippe Bouvet, Juan Elezgaray, Françoise Argoul. 


Ion Exchange in the Nonspecific Bimolecular Association and the 

Unimolecular DNA Bending in Specific Binding of IHF to DNA. 

Paula Vivas, Serguei V. Kuznetsov, Anjum Ansari. 


Analysis of RPA70N Involvement in RPA ssDNA Binding Activity. 

Amalchi Castillo. 


The Role of DNA “Bendability” in the Indirect Read-Out Mechanism of 

Protein-DNA Interactions. Paula Vivas, Velmurugu Yogambigai, 

Serguei V. Kuznetsov, Anjum Ansari. 


Mechanisms of the Type I Restriction Enzyme EcoKI: Characterizing weak interactions 

using AFM. Kelly J. Neaves, David TF Dryden, 

J Michael Edwardson, Robert Henderson. 


Transcriptional Activation by the Human Progesterone Receptor: Towards a 

Predictive Understanding. Keith D. Connaghan, Aaron F. Heneghan, 

Michael T. Miura, David L. Bain. 


Unravelling The Role Of Alba In The Organization Of The Archaeal 

Nucleoid. Maarten C. Noom, Felix J.H. Hol, Niels Laurens, 

Malcolm F. White, Remus T. Dame, Gijs J.L. Wuite. 


Regulation of the nucleic acid chaperone activity of HTLV-1 Nucleocapsid 

Protein. Ioulia Rouzina, Kristen Stewart-Maynard, Fei Wang, 

Margareta Cruceanu, Dominic Qualley, Dominic Qualley, Mithun Mitra, 

Robert Gorelick, Mark Williams, Karin Musier-Forsyth. 


DNA Interaction Properties of Nucleic Acid Chaperone Proteins from 

Retrotransposons. Kathy R. Chaurasiya, Fei Wang, Gaël Cristofari, 

Jean-Luc Darlix, Sandra L. Martin, Mark C. Williams. 

24 


The Codes of “Non-Coding” ncRNA in Epigenetics: Episcription and 

Hermeneutics of the Genome in the Entangled Cancer-Angiogenesis-Tolerance 

Epigenome. Josef H. Wissler. 


Linking Yeast Transcription Factor Structural Class and Detailed Binding 

Preferences with in vivo Regulatory Functions. Rachel Patton McCord, 

Cong Zhu, Trevor W. Siggers, Martha L. Bulyk. 


Dissecting the High Rate Constant for the Binding of a Ribotoxin to the 

Ribosome. Sanbo Qin, Huan-Xiang Zhou. 


Insight into the Roles of the 140–149 Catalytic Loop and the Zinc-Binding 

Domain for HIV-1 Integrase Activity. Kevin Carayon, Li Na, 

Olivier Delelis, Francoise Simon, Jean-Francois Mouscadet, 

Jean-Francois Mouscadet, Jean-Claude Brochon, Eric Deprez. 


Single Molecule Measurements Of The Role Of Tetramer Opening In LacImediated 

DNA Looping. Danielis Rutkauskas, Francesco Vanzi, 

Hongli Zhan, Kathleen S. Matthews, Francesco S. Pavone. 


The Enfolding Arms of EcoRI Endonuclease as Probed by ESR Experiments. 

Jacqueline E. Townsend, Katherine Stone, Zhongyu Yang, Jessica Sarver, 

Sunil Saxena, Linda Jen-Jacobson. 


Nuclear RISC Originates from Cytoplasmic Loaded RISC in Human Cells. 

Joerg Muetze, Thomas Ohrt, Wolfgang Staroske, Karin Crell, Petra Schwille. 


A Dna Mimic Caught In The Act: 3d Electron Microscopy Shows Ecoki 

Methyltransferase In Complex With The T7 Antirestriction Protein Ocr. 

Christopher Kennaway, Agnieszka Obarska-Kosinska, John H. White, 

Irina Tuszynska, Laurie P. Cooper, Janusz M. Bujnicki, John Trinick, 

David T F Dryden. 


Investigation of Dnmt1-DNA Interaction using Fluorescence Fluctuation 

Spectroscopy. Matthias Hoeller, Karin Fellinger, Carina Frauer, 

Heinrich Leonhardt, Don C. Lamb. 


Thermodynamic Characteristics of pre-mRNA Splice Site Recognition. 

Krystle J. Williams, Jermaine L. Jenkins, Clara L. Kielkopf. 


The DNA Bridging Protein H-NS and the SsrB Transcription Factor 

Counteract One Another to Silence and Activate Pathogenicity Island Genes in 

Salmonella. Yinjie Liu, Don Walthers, Linda J. Kenney, Jie Yan. 


TBP Carries Out Specific DNA Binding Involving Information From Both 

Grooves. Cesar Millan-Pacheco, Victor M. Capistran-Licea, Nina Pastor. 


Recognition and Signaling in DNA Mismatch Repair: MD Studies of MutS 

Complexes with DNA and ATP. Susan N. Pieniazek, Manju Hingorani, 

David L. Beveridge. 


In Silico Study Of Nonspecific DNA-protein Encounter Complexes. 

Mu Gao, Jeffrey Skolnick. 


Understanding DNA- and RNA-binding Proteins Using Sequence and 

Structural Features. Matthew B. Carson, Robert Langlois, Hui Lu. 

Protein Structure (Boards #B211–#B230) 


Protein Structure Initiative-Materials Repository (PSI-MR): An open shared 

public resource for structural genomic plasmids. Catherine Cormier, 

Joshua LaBaer, Jean Chin. 


From The Polymer Nature Of Proteins To The Evolution Of Protein 

Function. Igor Berezovsky, Alexandr Goncearenco. 


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Predictions of Protein Circular Dichroism Calculated by the Dipole Interaction 

Model and Compared to Synchrotron Radiation Circular Dichroism 

Experiments. Kathryn A. Thomasson, Neville Y. Forlemu. 


New Spin Label Designed for Double Electron-Electron Resonance Distance 

Measurements in the Liquid Nitrogen Temperature Range. Sandra S. Eaton, 

Gareth R. Eaton, Velavan Kathirvelu, Andrzej Rajca, Sandip K. Roy, 

Suchada Rajca, Shuzhang Xiao, Maren Pink. 


Ensemble Dynamics with Orientational NMR Restraints in Solution and 

Membrane Environments. Sunhwan Jo, Jinhyuk Lee, 

Thenmalarchelvi Rathinavelan, Wonpil Im. 


Molecular Dynamics Simulations Of Escherichia coli Acyl Carrier Protein 

Containing Fatty Acyl Derivatives. David I. Chan, D. Peter Tieleman, 

Hans J. Vogel. 


The Dependence Of Coiled-coil Chirality On Elastic Energy. Sara Sadeghi, 

Eldon Emberly. 


Computational Modeling of the Structural Mechanism Linking Ligand and 

Corepressor Binding to Thyroid Hormone Receptors. Yi Chen. 


Effects Of Reactive Oxygen Species On Cyan Fluorescent Protein. 

Luis Alvarez, Fabienne Merola, Chantal Houée-Levin, Filippo Rusconi, Marie 

Erard. 


Thermodynamic Intermediates of the Alkaline III˘ IV Transition in 

Ferricytochrome c Probed by 695 nm Charge Transfer Band. Daniel Verbaro, 

Andrew Hagarman, Carmichael Wallace, Reinhard Schweitzer-Stenner. 


X-ray Footprinting at Beamline X28C: A National Resource for Studying 

Macromolecular Structure and Dynamics. Rhijuta D’Mello, Sayan Gupta, 

Jen Bohon, Donald Abel, John Toomey, Michael Sullivan, Mark R. Chance. 


Expression and Purification of the Myxoma Virus Leukemia Associated Protein 

Zinc Finger Domain. Bryan G. Hahn, Dominic Esposito, Dana C. Lawrence. 


Expression and Purification of Zinc Finger Antiviral Protein. 

Christina M. Zimmerman, Dominic Esposito, Dana C. Lawrence. 


Troponin T Deletion 96 Related to Restrictive Cardiomyopathy Ablates the 

Effects of Cardiac Troponin I PKA Pseudo-Phosphorylation on Ca 21 

Sensitivity of Force Development. Michelle S. Parvatiyar, Jose R. Pinto, 

Jingsheng Liang, Michelle A. Jones, James D. Potter. 


Structural Comparison Of A Diabetes Drug Target, Mitoneet, A 2Fe-2S 

Cluster Protein To Its More Stable Mutant, H87C. Andrea R. Conlan, 

Herbert L. Axelrod, Aina E. Cohen, Edward C. Abresch, Rachel Nechushtai, 

Mark L. Paddock, Patricia A. Jennings. 


Crystallographic Structure And Structural Stability Of Vertebrate Digestive 

Lysozyme. Yasuhiro Nonaka, Daisuke Akieda, Nobuhisa Watanabe, 

Masakatsu Kamiya, Tomoyasu Aizawa, Makoto Demura, Keiichi Kawano. 


Structural Determination of the Carboxyl Terminal Domain from the Gap 

Junction Protein Connexin45. Jennifer L. Kopanic, Fabien Kieken, 

Paul L. Sorgen. 


Structural and Functional Basis for (S)-allantoin Formation in the Ureide 

Pathway. Kwangsoo Kim, Jinseo Park, Sangkee Rhee. 


A Folding Switch Regulates the Phd/doc Operon by Conditional 

Cooperativity. Abel Garcia Pino, Lode Wyns, Remy Loris. 



Double Hexamer Structure Of The Archaeal Helicase MCM From 

Methanobacterium thermoautotrophicum. Yacob Gomez-Llorente, 

Ryan J. Fletcher, Xiaojiang S. Chen, José María Carazo, 

Carmen San Martín. 

Protein Dynamics I (Boards #B231–#B260) 


Dynamics and Statistical Properties of Disordered Proteins. Vijay Singh, 

Yujie Chen, Bill Wedemeyer, Lisa Lapidus. 


Probing the cytoplasmic substrate permeation pathway of the Serotonin transporter 

with Steered Molecular Dynamics simulation. Anshu Bhatia, Lei Shi, 

Harel Weinstein. 


Solvent Effects On Protein Mechanical Stability: A Steered Molecular 

Dynamics Study. Georgi Z. Genchev, Hui Lu. 


Fluorescence Resonance Energy Transfer Reveals Key Binding Domains of 

Neurotrophin Receptor-Interacting Melanoma-Associated Antigen Homolog 

in Bone Morphogenetic Protein-Mediated Apoptosis. Jennifer A. Rochira, 

Rebecca A. Cowling, Joshua S. Himmelfarb, Samuel T. Hess, Joseph M. Verdi. 


Conformational Dynamics of Antithrombin III With its Allosteric Activator 

Heparin. Lauren Boucher, Richard de la Cruz, Susan Bock, 

Patrick L. Wintrode. 

357-POS BOARD #B236 INTERNATIONAL TRAVEL AWARDEE 

Structural Evaluation of the Effects of Disulfide Bond Eliminations on 

Scorpion Toxin k-Hefutoxin1 from Heterometrus fulvipes. 

Mehriar Amininasab, Maryam Ghobeh. 


Characterization of HIV-1 Protease-Inhibitor Interaction by Interflap Distance 

Measurement, NMR Spectroscopy, and Solution Kinetics. Angelo M. Veloro, 

Mandy E. Blackburn, Luis Galiano, Gail E. Fanucci. 


Picosecond Dynamics Of Surface Water As A Function Of Hydrophobicity. 

Wei Liang, Yunfen He, Deepu George, Andrea G. Markelz. 


The Scaffolding Subunit of PP2A is a Coherent Linear Elastic Object That 

Can Transmit Mechanical Information Along Its Length. Alison E. Grinthal, 

Ivana Adamovic, Martin Karplus, Nancy Kleckner. 


The Closure Mechanism Of M. Tuberculosis Guanylate Kinase Relates 

Structural Fluctuations To Enzymatic Function. Olivier Delalande, 

Sophie Sacquin-Mora, Marc Baaden. 


The Closed ,-.Open Transition of Adenylate Kinase From Crystal Structures 

and Computer Simulations. Oliver Beckstein, 

Elizabeth J. Denning, Thomas B. Woolf. 


Conserved Protein Flexibility And Pathways Of Energy Flow In Enzyme 

Catalysis. Arvind Ramanathan, Jose Borreguero, Christopher J. Langmead, 

Pratul K. Agarwal. 


Accelerated Target Selection By Repair Enzymes Through Charge Transport. 

Pak-Wing Fok, Tom Chou. 


Reference-Free Identification of Dynamic Structural Domains in Proteins: 

Comparison of Numeric Predictions with NMR Measurements. 

Maria Stepanova. 


Spontaneous Substrate Binding and Formation of the Bound State in Glycerol- 

3-Phosphate Transporter (GlpT). Giray Enkavi, Emad Tajkhorsid. 


Single Molecule Fret Reveals Novel Dynamic Structure And Stoichiometry Of 

L27 Domain-mediated Polarity Complexes Formed By Drosophila 

Sdt/DPatj/DLin-7. Andreas Renner, Suren Felekyan, Heike Hornen, 

Paul J. Rothwell, Stanislav Kalinin, André Bachmann, Elisabeth Knust, 

Claus AM Seidel. 

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Conformational Flexibility of the GM2 Activator Protein Loop Regions 

Investigated By Site Directed Spin Labeling EPR Spectroscopy. 

Jordan D. Mathias. 


Single-Molecule Protein Conformational Dynamics and Molecular Interaction 

Dynamics under Enzymatic Reactions. Yufan He, Saptarshi Mukherjee, 

H. Peter Lu. 


Slippage Between Noncovalently Bound Filaments Of Self-assembling Peptide. 

Nathan A. Hammond, Roger D. Kamm. 


Multiple Channels of Structural Relaxations in Functional Proteins. 

Canan Atilgan, Osman B. Okan, Ali Rana Atilgan. 


Solvent Bridging Determines The Molecular Architecture Of The Unfolding 

Transition State Of A Protein. Lorna Dougan, Georgi Genchev, 

Jorge Alegre-Cebollada, Hui Lu, Julio M. Fernandez. 


Site-Specific Folding Dynamics of Isotopically Labeled Peptides Studied by 

Time-Resolved Infrared-Spectroscopy. Carsten Krejtschi, Ling Wu, 

Rong Huang, Karin Hauser, Timothy A. Keiderling. 


Linear Response of Biomolecules To External Perturbations: Revisit Induce-fit. 

Lee Wei Yang, Akio Kitao, Nobuhiro Go. 


Dynamic Allostery In Proteins. Hedvika Toncrova, Thomas CB McLeish. 


Impact of Hofmeister Salts on Structural Dynamics of Photoactive Yellow 

Protein. Sandip Kaledhonkar, Lorand Kelemen, Anupama Thubagere, 

Yunxing Li, Aihua Xie. 


Linking Enzyme Conformational Dynamics To Catalytic Function With 

Single-molecule FRET. Yan-Wen Tan, Jeffrey A. Hanson, Jason Brokaw, 

Jhih-Wei Chu, Haw Yang. 


Two-colors Photo-Switching of E222Q-GFPMut2 Mutant by Fluorescence 

Correlation Spectroscopy. Valentina Quercioli, Chiara Bosisio, 

Maddalena Collini, Laura D’Alfonso, Giuseppe Chirico. 


Conformational Transitions Of Disordered Proteins Associated With Different 

Redox States Of Di-thiol Pairs. Samuel W. Fan, Richard A. George, 

Naomi L. Haworth, Lina L. Feng, Jason Y. Liu, Merridee A. Wouters. 


“Arrhenius Approach to Study Kinetics of Fresh Egg Protein” . Dipti Sharma. 


NMR Dynamics Of PSE-4 b-lactamase: An Interplay Of ps-ns Order And 

m s-ms Motions In The Active Site. Sébastien Morin, 

Stéphane M. Gagné. 

Protein Assemblies (Boards #B261–#B278) 


SEDPHAT - An Analysis Platform for the Biophysical Analysis of Reversibly 

Assembled Multi-protein Complexes in Solution. Patrick H. Brown. 


Probing the Heterogeneity in the Distribution of Binding Properties of 

Immobilized Surface Sites through Bayesian Analysis. Huaying Zhao, 

Inna I. Gorshkova, Juraj Svitel, Faezeh Razjouyan, Peter Schuck. 


Proteomic Analysis of KvLQT1 and HERG-associated Proteins. 

Hitesh K. Jindal, Gideon Koren. 


Computer Simulation of Protein-Protein Association Processes. 

Volkhard Helms, Mazen Ahmad, Alexander Spaar, Wei Gu. 


At clinically relevant concentration Isoflurane and Desflurane induce Abeta 

oligomerization. Molecular details from NMR spectroscopy. 

Pravat K. Mandal, Vincenzo Fodale. 

26 


Molecular Dynamics Simulations of a Single 11-Residue Beta-Sheet Adhesive 

and its Assembly. Ahlam N. Al-Rawi, Brigita Urbanc, Debabani Ganguly, 

Talat S. Rahman, Jianhan Chen, John Tomich. 


Peptide Nanocapsules As Novel Immunogens: Design And Biophysical 

Analysis Of A Prototype SARS Vaccine. Tais Pimentel, Zhe Yan, 

Scott A. Jeffers, Kathryn V. Holmes, Robert S. Hodges, Peter Burkhard. 


Peptide Nanocapsules and Their Conjugation with Inorganic Nanoparticles. 

Yongkun Yang, Peter Burkhard. 


Properties of Glycan-Rich Pericellular Coats - A Study on a Well-Defined 

Model System. Ralf P. Richter, Natalia Baranova, Patricia Wolny. 


Conformational Change of ClpP from Bacillus subtilis Characterized by 

Electron Microscopic study. Byung-Gil Lee Lee, Hyun Kyu Song, 

Hyesung Jeon. 


The Role of the Proline Rich Domain in the Structural Organization of 

Dynamin. Pampa Ray, Shunming Fang, Jason A. Mears, Jenny E. Hinshaw. 


Structural Basis For HIV-1 DNA Integration in the Human Genome. 

Fabrice Michel, Corinne Crucifix, Florence Granger, Sylvia Eiler, 

Jean François Mouscadet, Marina Gottikh, Alexis Nazabal, 

Stéphane Emiliani, Richard Benarous, Dino Moras, Patrick Schultz, 

Marc Ruff. 


Structural studies of a phycobilisome. Marta C. Bunster, Carola E. Bruna, 

Jose A. Martinez-Oyanedel, Maximiliano Figueroa, Carolina Meza, 

Jose R. Sepulveda, Adelio Matamala. 


Quantification of the Exchange of Subunits from Membrane Protein 

Complexes Using Foerster Transfer Recovery (FTR). Zhanjia Hou, 

Kenneth S. Campbell, Seth L. Robia. 


Ligand Binding and Sickle Hemoglobin Polymerization Kinetics: Implication 

for Therapies. Donna Yosmanovich, Maria Rotter, Alexey Aprelev, 

Frank A. Ferrone. 


Fiber Depolymerization: Fracture, Fragments, Vanishing Times and Stochastics 

in Sickle Hemoglobin. Jiang Cheng Wang, Suzanna Kwong, Frank A. Ferrone, 

Matthew S. Turner, Robin W. Briehl. 


A Repulsive Electrostatic Mechanism For Protein Translocation Through Type 

III Secretion System: Insights From Pulling Simulations Of MxiH Across The 

Needle Apparatus Of Shigella flexneri. Thenmalarchelvi Rathinavelan, 

Wendy Picking, Roberto De N. Guzman, Wonpil Im. 


Solid-State NMR Studies of Gas Vesicle Structure. Astrid C. Sivertsen, 

Marvin J. Bayro, Marina Belenky, Robert G. Griffin, Judith Herzfeld. 

Protein Folding & Stability I (Boards #B279–#B305) 


Sequence-dependent Stability Of The Beta-helical Fold. Natha Robert Hayre, 

Daniel Lee Cox, Rajiv R.P. Singh. 


Investigating the Origins of Fractional c-values in Protein Folding Transition 

States. Michael C. Baxa, Karl F. Freed, Tobin R. Sosnick. 


Electrostatic Interaction In The Unfolded States Of Proteins. Jana Khandogin. 


Non-Native Structure in the Unfolded Ensemble of a Prototypical b-Hairpin. 

Massimiliano Bonomi, Davide Branduardi, Francesco L. Gervasio, 

Michele Parrinello. 


Beta-barrel Proteins that Reside in the E. coli Outer Membrane In Vivo 

Demonstrate Varied Folding Behavior In Vitro. Nancy K. Burgess, 

Karen G. Fleming. 


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Bistable Entropy Landscape of Sequences and Folds of Proteins. 

Baoqiang Cao, Ron Elber. 


Amyloid b Proteins, Modified by a Lipid Oxidation Product, Are Nucleation 

Sites for Fibril Formation on Lipid Membranes. Hiroaki Komatsu, Liu Liu, 

Paul H. Axelsen. 


Rescuing Functional Protein from Amyloid-Like Structure. Gergely Agócs, 

Katalin Solymosi, Andrea Varga, Péter Závodszky, Judit Fidy, 

Szabolcs Osváth. 


Dissecting the N-terminal Helical Domain of Apolipoprotein B. 

Laura E. Packer, Zhenghui Gordon Jiang, C. James McKnight. 


Peptide Structure Stabilization: A Study Of Aromatic-aromatic Interaction And 

pH Effect On A b-hairpin Stability. Ling Wu, Takahiro Takekiyo, 

Dan McElheny, Timothy A. Keiderling. 


Molecular Partition Functions For Amino Acids And Beyond. Hui Wang, 

Michael Farchild, Dennis R. Livesay, Donald J. Jacobs. 


Lin-12/Notch Repeat B: The Effects Of Disulfide Bonding And Hydrophobic 

Residues On Its Autonomous Folding. Jessica Lin, Didem Vardar-Ulu. 


Lattice Model Studies of Designability and Alpha-helix to Beta-sheet 

Transitions of Short Peptide Chains. Travis A. Hoppe, Jian-Min Yuan. 


Atomistic Modeling of Macromolecular Crowding Predicts Modest Increases in 

Protein Folding and Binding Stability. Sanbo Qin, Huan-Xiang Zhou. 


Forced Unfolding of CTPR proteins. Gregg Lois, Jerzy Blawzdziewicz, 

Corey OHern. 


Dodging The Crisis Of Folding Proteins With Knots. Joanna I. Sulkowska, 

Piotr Sulkowski, Jose Onuchic. 


Continuous Dissolution Of Structure During The Unfolding Of A Small 

Protein. Santosh Kumar Jha, Deepak Dhar, G. Krishnamoorthy, 

Jayant B. Udgaonkar. 

417-POS BOARD #B296 MINORITY BIOPHYSICISTS TRAVEL GRANT 

AWARDEE 

Experimental Studies on Protein Folding in the Presence of the Hsp70 

Chaperone System. Margarita Santiago, Ashok Sekhar, Silvia Cavagnero. 


Folding Mechanism Of The Z Mutant Of Human Antitrypsin Studied By 

H/D Exchange. Tanusree Sengupta, Patrick L. Wintrode. 


Urea H-bonds to the peptide group, but Gdm does not. Woon K. Lim, 

Jörg Rösgen, Walter Englander. 


The Effect of High Concentration Salt on the Structure, Stability, and 

Aggregation of RecA. William R. Cannon, Gina MacDonald. 


Folding/Unfolding of Glycolipid Transfer Protein: Molten Globule-Like 

Intermediates?. Ravi Kanth Kamlekar, Roopa Kenoth, Helen M. Pike, 

Franklyn G. Prendergast, Sergei Yu. Venyaminov, Rhoderick E. Brown. 


Elucidating The Specificity Determinants Responsible For ClpX-Adaptor 

Interaction. Tahmeena Chowdhury, Peter Chien, Robert T. Sauer, 

Tania A. Baker. 


The Effect of Salts and Co-Solvents on the Cytochrome c Folding Pathway 

within a Sol-gel Glass. Eric S. Peterson, Michael A. Erbele, Brock B. Jas. 


Prosegment Catalyzes Pepsin Folding to a Kinetically Trapped Native State. 

Derek R. Dee, Rickey Y. Yada. 



Osmolytes Control Peptide Folding and Aggregation. Regina Politi, 

Shahar Sukenik, Daniel Harries. 


The Effects of Reduction Potential and Number of Disulfide Bonds on the 

Correct Folding of Lin-12/Notch Repeats (LNRs) Using Human Notch 1 

LNRA as a Model System. Lauren Choi, Didem Vardar Ulu. 


Helical Flexibility Governed by the Placement of Alanine Residues in a Series of 

Aib-Rich Model Peptides. Matthew Cocchiola, Valentine Sackmann, 

Adrienne P. Loh. 

Molecular Recognition in Silico (Boards #B307–#B322) 


Free Energy Calculations of Sparsomycin Analogs Binding to the Ribosome 

with Molecular Dynamics Simulations. Xiaoxia Ge, Benoit Roux. 


Computational Discovery Of The Electronegative Channel In RNA Loop-loop 

Interactions. Andrey Semichaevsky, Abhishek Singh, Yaroslava G. Yingling. 


Docking of a Linker Histone to The Nucleosome With Flexible Linker DNAs. 

Georgi V. Pachov, Rebecca C. Wade. 


Exploring The Spatiotemporal Dynamics of DNA Binding and Cleavage by 

Restriction Endonucleaes. Wei-Ting Wang, Jing-Shin Tsai, Chien-Ting Hsu, 

Tzu-Sen Yang*. 


Molecular Recognition Routes Of DNA By Anticancer Ligands: Mechanisms 

and Free Energies Explored Via Molecular Dynamics Simulations. 

Attilio Vittorio Vargiu, Alessandra Magistrato, Paolo Carloni, 

Paolo Ruggerone. 


Computational Studies of Substrate Binding and Conformational Change in 

the Glycine Betaine Symporter BetP. Kamil Khafizov, Christine Ziegler, 

Lucy Forrest. 


Substrate Binding Directs the Functional Hinge Bending Motion of Human 3- 

Phosphoglycerate Kinase. Erika Balog, Zoltan Palmai, Laurent Chaloin, 

Corinne Lionne, Judit Fidy, David Perahia. 


Molecular Dynamics Simulation Study of T Cell Receptor Molecular 

Recognition of Peptide-Major Histocompatibility Complexes. Ghalib A. Bello, 

Michael E. Paulaitis. 


Free Energy Calculation And Decomposition Of Hiv-1 Protease-Darunavir 

Binding By MM-PB/GBSA And Thermodynamic Integration Method. 

Yufeng Cai. 


Analyzing drug-resistance in terms of substrate recognition by Hepatitis C Virus 

NS3 protease. Keith Romano. 


Modeling Orientation-Constrained Reactions: A Study Of Crowding Effects 

With Brownian Dynamics Simulation. Jian Sun, Harel Weinstein. 


Parameter Effects Of Crowding On Binding Chemistry Using Stochastic Offlattice 

Simulations. Byoungkoo Lee, Philip R. LeDuc, Russell Schwartz. 


Interface Volume As A Possible Diagnostic Of The Quality Of Protein-protein 

Docking. Mihaly Mezei. 


The First Total Synthesis Of Morusin And Himanimide D As Arachidonate 5lipoxygenase 

Inhibitor In Automated Docking. Yean-Jang Lee, 

Chia-Fu Chang, Cheng-Wei Lin, Yu-Chao Huang, Chao-Chin Hu, 

Yen-Min Tsheng, Tsui-Hwa Tseng. 


Simultaneously Targeting Multiple Drug-Resistant Variants with Optimally 

Small Drug Cocktails: Application and Analysis of Novel Methods. 

Andrea P. Johnston, Mala L. Radhakrishnan. 

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High Throughput In-silico Screening Against Flexible Protein Receptors. 

Horacio E. Sánchez. 

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Protein Aggregates I (Boards #B323–#B343) 


Structural Investigation of an SH3 Amyloid Protein Fibril. Marvin J. Bayro, 

Thorsten Maly, Neil R. Birkett, Christopher M. Dobson, Robert G. Griffin. 


Solid-State NMR Studies of the Fibril Forming Protein PABPN1. 

Daniel Huster, Holger A. Scheidt, Grit Lodderstedt, Elisabeth Schwarz. 


Solid-state NMR Investigation of b2-Microglobulin Fibril Structure and 

Dynamics. Galia T. Debelouchina, Marvin J. Bayro, Geoffrey W. Platt, 

Sheena E. Radford, Robert G. Griffin. 


Native Conformation at Specific Residues in Inclusion Body Protein in Whole 

Cells Detected with Solid-State Nuclear Magnetic Resonance. 

Jaime Curtis-Fisk, Ryan M. Spencer, David P. Weliky. 


Different Individual Amyloid Fibrils Exhibit Different Beta Sheet Secondary 

Structures via Near-field Infrared Spectroscopy. Melissa Paulite, 

Zahra Fakhraai, Nikhil Gunari, Adrienne Tanur, Gilbert C. Walker. 


Evolution Of Protein Misfolding And Cell Apoptosis In Huntington’s Disease 

Studied By Synchrotron Infra-Red Microspectroscopy. Markus Bonda, 

Heike Runne, Bertrand Vileno, Valérie Perrin, Ariane Kretlow, 

Lisa M. Miller, László Forró, Ruth Lüthi-Carter, Sylvia Jeney. 


An Infrared 2D-COS Study of Fibril Formation. Jose Luis R. Arrondo, 

Igor De la Arada. 


Investigating Amyloid Aggregates At Different Size Scales. Suman Nag, 

Bankanidhi Sahoo, Jiji Chen, C. Muralidharan, Riddhi Shah, 

Joseph Irudayaraj, Sudipta Maiti. 


Amyloid Peptide Conformations In Soluble Oligomers. 

Jyothi L. Digambaranath, Ben P. Block, Tyler Campbell, Loan Dang, 

Monika Dembinska, Kim K. Williams, John M. Finke. 


Real-Time Monitoring of Heat Induced Unfolding and Aggregation of 

b-lactoglobulin in the Presence of Chaperones Using High Resolution 

Ultrasonic Spectroscopy. Agnieszka Ochenduszko, Vitaly Buckin. 


Detecting Protein Aggregation on Cells Surface: Concanavalin A Oligomers 

Formation. Valeria Vetri, Giulia Ossato, Valeria Militello, 

Michelle A. Digman, Maurizio Leone, Enrico Gratton. 


Protein aggregation in live cells: N&B analysis of Huntingtin. Giulia Ossato, 

Michelle Digman, Charity Aiken, Lawrence Marsh, Enrico Gratton. 


Sickle Hemoglobin Fiber Growth Rates Deduced Using Optical Channels. 

Alexey Aprelev, Mikhail Zakharov, Zenghui Liu, Matthew S. Turner, 

Frank A. Ferrone. 


A Unified Theory of Liquid-Liquid Demixing and Polymer Formation 

Kinetics. Frank A. Ferrone, Yihua Wang, Zenghui Liu, A. Emanuele, 

M. B. Vittorelli-Palma, M. U. Palma. 


Amyloid-like Aggregation Of A Human Apolipoprotein A-I Variant. 

Nahuel Ramella, M. Alejandra Tricerri, Susana A. Sanchez, Sergio T. Ferreira, 

Omar J. Rimoldi. 


Endogenous Formaldehyde Is Related To Sporadic Alzheimer’s Disease. 

Rongqiao He, Zhi Qian Tong, Jin Ling Zhang, Wen Hong Luo, 

Hui Li, Hong Jun Luo, Wen San Wang, Ying Liu. 


Intramolecular Diffusion of the Amyloidgenic Protein HypF. Yujie Chen, 

Lisa Lapidus. 


Amyloid Formation By Peptides From Yeast Adhesins. Caleen B. Ramsook, 

Gregory Soybelman, Ryan Henry, Raymond G. Fung, Peter N. Lipke. 


Conformational Instability, Aggregation, and Hydrogel formation of a 16- 

Residue Alanine-Based Peptide in Aqueous Media. Thomas J. Measey, 

Melinda Bendon, Reinhard Schweitzer-Stenner, Guoliang Yang, 

Konstantin Kornev. 


Study of Misfolding and Aggregation for Short Peptide from the Yeast Prion 

Sup35 Using AFM Imaging and Force Spectroscopy. 

Alexey V. Krasnoslobodtsev, Alexander M. Portillo, Luda S. Shlyakhtenko, 

Yuri L. Lyubchenko. 


On The Mechanisms Regulating Alpha-crystallin Activity. Marco De Spirito, 

Giuseppe Maulucci, Massimiliano Papi, Mauro Missori, Giuseppe Arcovito. 

Protein Aggregates II (Boards #B344–#B362) 


Effect Of Beta-sheet-breaker Peptides On The Assembly, Morphology And 

Mechanical Stability Of Oriented ab25–35 Amyloid Fibrils. Ünige Murvai, 

Arpad Karsai, Miklos S.Z. Kellermayer. 


Thermal Stability Of Oriented Ab25–35 Amyloid Fibril Nanoarray. Matyas 

Kolsofszki, Arpad Karsai, Miklos S. Kellermayer. 


Fibril formation of Ab (10–35) studied by UV resonance Raman Spectroscopy. 

Anwesha Bhattacharya, Maiko Kondo, Ishita Mukerji. 


Amyloid Beta Oligomer Formation Analysis by Photon Counting Histogram. 

Naofumi Terada, Tamotsu Zako, Masafumi Sakono, Mizuo Maeda. 


The Aggregation of Ab 16–22 Probed by Circular Dichroism and Infrared 

Spectroscopies. Andrea Grund, Elisa Frankel, Sean M. Decatur. 


Conformational Change Induced In A Random Coil Peptide By 

Prion Peptide Aggregates. Dana M. Alessi, Sean M. Decatur. 


Successful de novo conversion from [psi-] to [PSI1] Saccharomyces cerevisiae. 

Edward C. Koellhoffer, Hideyo Inouye, Daniel A. Kirschner. 


Conversion Of Antiparallel b-sheet To Parallel b-sheet In A Prion Peptide 

Aggregate. Dana M. Alessi. 


Probing the effect of Heat Shock Protein 70 on the aggregation of a-Synuclein. 

Evan T. Spiegel, Phill Jones, Pamela McLean, Brad Hyman, Warren R. 

Zipfel. 


The Effect of Cations on a-Synuclein Misfolding: Single Molecule AFM Force 

Spectroscopy Study. Junping Yu, Yuri L. Lyubchenko. 


A Single Mutation in the Non-Amyloidogenic Region of IAPP Greatly 

Reduces Toxicity. Kevin Hartman, Jeffrey R. Brender, Kendra R. Reid, 

Pieter E.S. Smith, Ravi P.R. Nanga, Marchello A. Cavitt, Edgar L. Lee, 

Duncan G. Steel, Ari Gafni, Robert T. Kennedy, Ayyalusamy Ramamoorthy. 


Curcumin Inhibits The Formation Of Fibrils From Islet Amyloid Polypeptide. 

Gai Liu. 


High-resolution Structures of Membrane-Bound IAPP Reveal Functional 

Implications of the Toxicity of Prefibrillar States of Amyloidogenic Proteins. 

Ravi P. R. Nanga, Jeffrey R. Brender, Kevin Hartman, 

Ayyalusamy Ramamoorthy. 


Amyloidogenic Propensity of ProIAPP and IAPP in the Presence of Negatively 

Charged Lipid Bilayers. Suman Jha. 


Structural Studies Of Islet Amyloid Polypeptide In The Presence Of Insulin 

And Lipid Membranes. Shuqiu Han. 


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Amyloid-like Misfolding Of Peptides By Membrane Mimicking 

Environments. Alex Perálvarez-Marín, Anna Wahlström, Jesper Lind, Loïc 

Hugonin, Jüri Jarvet, Lena Mäler, Andreas Barth, Astrid Gräslund. 


Modeling amyloid toxic ion channels. Hyunbum Jang, Ratnesh Lal, 

Ruth Nussinov. 


Probing Tau-Vesicle Interactions. Shana Elbaum, Jocelyn Traina, 

David Eliezer, Elizabeth Rhoades. 


An a-Helical Conformation of the SEVI Peptide, a Dramatic Enhancer of 

HIV Infectivity, Promotes Lipid Aggregation and Fusion. Jeffrey Brender, 

Kevin Hartman, Ravi PR Nanga, Stephanie V. Le Clair, Lindsey M. Gottler, 

Ayyalusamy Ramamoorthy. 

Lipids and Signaling on Membrane Surface 

(Boards #B363–#B373) 


The Preferential Reconstitution Of Ampa Receptor Proteins Into Model Lipid 

Domains With Cholesterol Studied By Atomic Force Microscopy - an Imaging 

And Force Spectroscopy Study. Chandra Ramanujan, Nahoko Kasai, 

Matthew Suggit, Jelena Baranovic, Keiichi Torimitsu, John F. Ryan. 


Piezoelectricity of phospholipids: Are cell membranes also piezoelectric?. 

Antal Jakli. 


SRAA POSTER 

Gastrin-Releasing Peptide Adopts An Orientation Parallel To The Membrane 

Plane As A Preferred Orientation In DMPC Bilayers: Multiple Molecular 

Dynamics Simulations. Priyanka Prakash Srivastava. 


Lipid Composition Modulates the Stability of DNA Acting as Model 

Membrane-bound Receptors. Paul A. Beales, T. Kyle Vanderlick. 


Phosphatidylinositol-(4,5)-bisphosphate Acting As A Ligand Of PKCalpha 

Modulates The Membrane Localization Of This Enzyme In Living Cells. 

Juan C. Gómez-Fernández, Consuelo Marin-Vicente, 

Francisco E. Nicolas, Senena Corbalán-García. 


Probing Phosphoinositide Kinetics With A Voltage-sensitive Phosphatase. 

Bjoern H. Falkenburger, Jill B. Jensen, Byung-Chang Suh, Bertil Hille. 


Interaction Of PTEN1–21 Peptide With Phosphatidylinositol-4,5-Bisphosphate: 

A P NMR Relaxation Study. Edgar E. Kooijman, Avigdor Leftin, 

Michael F. Brown, Arne Gericke. 


Plasma Membrane Order In T Cell Signalling. Jelena Dinic, Jeremy Adler, 

Ingela Parmryd. 


Adsorption Of Bar-domain Proteins To Charged Lipid Membranes Causes 

Deformations And Lipid Demixing. George Khelashvili, Daniel Harries, 

Harel Weinstein. 


Inducing and Reversing Anesthesia with Temperature Variation - Experiments 

on an Excised Frog Sciatic Nerve. Bineyam Kassahun, Martin Bier, 

Alexander Murashov. 


Ci-VSP Is A Depolarization-Activated PI(4,5)P2 And PI(3,4,5)P3 59 

Phosphatase. Christian R. Halaszovich, Dominik Oliver. 

IP3 Receptors (Boards #B374–#B381) 


Toward A Computational Model Of IP3R1-associated Ataxia. 

Sherry-Ann Brown, Leslie M. Loew. 


Electron Cryomicroscopy of IP3R1 Calcium Release Channel. Que T. Ngo, 

Joshua T. Maxwell, Gregory A. Mignery, Wah Chiu, Steven J. Ludtke, 

Irina I. Serysheva. 



The Amplification Of InsP3R Activity By NCS-1 Is Attenuated By 

Medications Used In The Treatment Of Bipolar Disorder. Christin Schulze, 

Jessica Olofsson, Barbara E. Ehrlich. 


The Role of the Pore-forming Region in the Regulation of IP3 Receptor by 

Luminal Ca21. Shitian Cai, Wenqian Chen, Lin Zhang, Wayne S.R. Chen. 


A C-terminal Fragment of Chromogranin B Amplifies Inostiol (1,4,5)- 

Trisphohsphate Receptor Mediated Signaling. Stefan Schmidt, 

Felix M. Heidrich, Michelle Mo, Barbara E. Ehrlich. 


Comparison of IP3R and RyR Expression and Ca 21 Release Characteristics in 

Isolated Cardiac Nuclei. Susan Currie, Richard D. Rainbow, 

Marie-ann Ewart, John G. McCarron. 


Type 2 Inositol 1,4,5-trisphosphate Receptor Phosphorylation and Modulation 

by Ca 21 /Calmodulin-dependent Protein Kinase II. Joshua T. Maxwell, 

Ademuyiwa S. Aromolaran, Gregory A. Mignery. 


Regulation Of Inositol 1,4,5-Trisphosphate Receptor Isoforms By O-Linked 

Glycosylation. Patricia Bimboese, Craig J. Gibson, Stefan Schmidt, 

Jere Paavola, Barbara E. Ehrlich. 

Exocytosis & Endocytosis (Boards #B382–#B410) 


Bioanalytical Analysis of Bis(monoacylglycero)phosphate (BMP) Model Lipid 

Membranes. Janetricks N. Chebukati, Gail E. Fanucci. 


Pacap Acts As A Transmitter At The Sympatho-adrenal Synapse Under The 

Acute Stress Response. Barbara A. Kuri, Shyue-An Chan, Corey Smith. 


Jamming Dynamics Of Stretch-induced Surfactant Secretion By Alveolar 

Epithelial Cells. Arnab Majumdar, Stephen P. Arold, Erzsebet Bartolak-Suki, 

Harikrishnan Parameswaran, Bela Suki. 


Action Potential Code And Cocaine Modulates Dopamine Release In Mice 

Striatum in vivo. PL Zuo, XJ Kang, J Fan, Q Lei, SR Wang, W Yao, T Luo, 

YF Xiong, HQ Dou, XY Liu, CH Wang, S Guo, CX Zhang, HH Gu, 

Zhuan Zhou. 


Monitoring Exocytosis And Endocytosis At Neuronal Cells Using A Quartz 

Crystal Microbalance Technique With Simultaneous Amperometric Detection. 

Ann-Sofie Cans. 


Probing Exocytosis In Blood Platelets. Shencheng Ge, Nathan J. Wittenberg, 

Emily Woo, Christy L. Haynes. 


Ca 21 Syntillas Inhibit Spontaneous Exocytosis In Mouse Adrenal Chromaffin 

Cells. Jason J. Lefkowitz, Kevin E. Fogarty, John V. Walsh, Jr., 

Valerie De Crescenzo. 


F-actin Re-organization Through MARCKS and Myosin II Activity Regulates 

Quantal Exocytosis. Bryan Doreian, Robert Mecklemburg, Corey Smith. 


Fusion Pore Regulation of Peptidergic Vesicles. Jernej Jorgačevski, 

Matjzˇ Stenovec, Marko Kreft, Aleksandar Bajic, Bosˇtjan Rituper, 

Nina Vardjan, Stanko Stojilkovic, Robert Zorec. 


Synchronous Versus Asynchronous Contributions to Frequency-induced 

Synaptic Depletion in Zebrafish. Hua Wen, Paul Brehm. 


Norepinephrine Inhibits Endocytosis In Insulin-secreting Cells. Ying Zhao, 

Qinghua Fang, Susanne G. Straub, Lindau Manfred, Geoffrey W.G. Sharp. 


Secretory Phospholipase A2 Type III Enhances a-secretase-dependent Amyloid 

Precursor Protein Processing by its Effect on Membrane Fluidity and 

Endocytosis. Xiaoguang Yang, Wenwen Sheng, Mark Haidekker, Grace Sun, 

James Lee. 

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Quantification of Noise Sources for Amperometric Measurement of Quantal 

Exocytosis Using Ultramicroelectrodes. Jia Yao, Kevin Gillis. 


Calcium/synaptotagmin-mediated Compound Fusion Increases Quantal Size 

And Causes Post-tetanic Potentiation At Synapses. Liming He, Lei Xue, 

Jianhua Xu, Benjamin D. McNeil, Ernestina Melicoff, Roberto Adachi, 

Ling-Gang Wu. 


Evidence Of A Role For SNAP-25 As A v-SNARE In Vitro. 

Brandon E. Forbes, Nathan C. La Monica, Gary R. Edwards, 

Dixon J. Woodbury. 


Massive Endocytosis (MEND) Activated By Ca and Polyamines in Fibroblasts 

and Cardiac Myocytes: Optical Studies of Membrane and Na/Ca Exchanger 

(NCX1) Internalization, The Possible Role of Ca-activated Transglutaminase in 

MEND, and The Possible Function of. Simona Magi, Alp Yaradanakul, 

Marc Llaguno, Mei-Jung Li, Chengcheng Shen, Michael Fine, Debora Nicoll, 

Donald W. Hilgemann. 


A New Method for Studying Apical Membrane Trafficking. 

Roland Thuenauer, Thomas Fruehwirth, Peter Pohl, Alois Sonnleitner. 


Constitutive and Ca 21 -stimulated Turnover of the Plasma Membrane Vacuolar 

H 1 -ATPase (V-ATPase) in Murine Osteoclasts. Hiromu Sakai, Takuya 

Notomi, Yoshie Moriura, Junko Kawawaki, Miyuki Kuno. 


Characterizing the Conformation of the Yeast Endocytic Scaffold Protein Pan1. 

B Daniel Pierce, Beverly Wendland. 


Single Fluorophore Detection And Tracking Of Fluorescent Weibel-Palade 

Body Membrane Proteins During Exocytosis. Gregory Mashanov, 

Nikolai Kiskin, Laura Knipe, Justin Molloy, Matthew Hannah, Tom Carter. 


A Role For Protein Phosphorylation In Fusion Pore Opening And Transmitter 

Release. Qinghua Fang, Ying Zhao, Khajak Berberian, Joan S. Lenz, 

Manfred Lindau. 


Effects of Calcium and PIP2 on the Membrane Binding of Synaptotagmin I. 

Weiwei Kuo, Dawn Z. Herrick, David S. Cafiso. 


A Novel Approach For Wireless Communication Of In Vivo Data From Freely 

Moving Research Animals. Khajak Berberian, Alycia Gailey, 

Michael G. Kaplitt, Manfred Lindau. 


Intracellular Ca 21 In Physiological Range Affects The Forward Rate Of Priming 

Of Large Dense Core Vesicles, But Not The Backward Rate. 

Mathias Pasche, Detlef Hof, Ulf Matti, Jens Rettig, Ute Becherer. 


Role Of SPIN90 (SH3 Protein Interacting With Nck, 90kda) In The 

Formation Of Endocytic Vesicle And Its Movement In Receptor-mediated 

Endocytosis. Hye Jin Oh. 


TIRF-FRET As An Approach To Quantitative Analysis Of Dynamic 

Molecular Interactions On Secretory Granules In Live Cells. Alice D. Lam, 

Edward L. Stuenkel. 


Patterning Single Cell-Electrode Pairs for Electrochemical Measurement of 

Quantal Exocytosis on Microchips. Xin Liu, Syed Barizuddin, 

Cherian J. Mathai, Shubhra Gangopadhyay, Kevin D. Gillis. 


Endophilin N-BAR Domains-induced Membrane Remodeling Revealed By 

Molecular Dynamics Simulations. Haosheng Cui, Gary S. Ayton, 

Gregory A. Voth. 


Chronic Palmitate Exposure Inhibits Insulin Secretion By Dissociation Of 

Ca 21 -Channels From Secretory Vesicles. Michael B. Hoppa, Stephan Collins, 

Reshma Ramracheya, Paul Johnson, Frances M. Ashcroft, Patrik Rorsman. 

30 

Endoplasmic Reticulum & Protein Trafficking 

(Boards #B411–#B421) 


Conformational transition of the Sec translocon induced by channel partner: A 

molecular dynamics study. Takaharu Mori, Ryuichiro Ishitani, 

Tomoya Tsukazaki, Osamu Nureki, Yuji Sugita. 


Simulations Of Multi-protein Complexes: Structure, Binding Affinity, And 

Dynamics Of Vps27/hse1 Bound To Membrane-tethered Ubiquitin. 

Youngchan Kim, James H. Hurley, Gerhard Hummer. 


Modulation of Membrane Mechanical Properties by Sar1, a Vesicle Trafficking 

Protein. Raghuveer Parthasarathy. 


Blocking helix formation without blocking organellar localization in 

Plasmodium falciparum. John R. Gallagher, Sean T. Prigge. 


Mapping Of The Signal Peptide-binding Domain Of Escherichia coli SecA 

Using Förster Resonance Energy Transfer. Sarah M. Auclair, Julia P. Moses, 

Monika Musial-Siwek, Debra A. Kendall, Ishita Mukerji, Donald B. Oliver. 


Evaluating Protein Interactions & Organelle Dynamics in Saccharomyces 

cerevisiae: Spatial Distribution of Molecular Chaperone/Co-Chaperones 

Evident at a Sub-organelle Level in the Endoplasmic Reticulum. 

Carissa L. Young, David Raden, Anne S. Robinson. 


Microtubule Network is Necessary to Direct and Maintain The Apical 

Localization of Slo1 Channels in Epithelial Cells. 

Enrique Alejandro Sanchez-Pastor, Jimmy W. Ou, Abderrahmane Alioua, 

Pallob Kundu, Enrico Stefani, Ligia Toro. 


N-Terminal LQT2 Nonsense Mutations Cause a Dominant-Negative 

Destabilization of WT hERG Subunits. Elon C. Roti Roti, Gail A. Robertson. 


hERG Trafficking is Dependent on a Cytosolic Chaperone Network. 

Valerie Walker, Jason Young, Alvin Shrier. 


Characterizing Nicotine-Induced a4* nAChR Upregulation with Fluorescence 

Microscopy. Rigo Pantoja, Rahul Srinivasan, Fraser J. Moss, 

Sindhuja Kadambi, Princess I. Imoukhuede, Henry A. Lester. 


Protein Kinase C Regulation Of KATP Channel Recycling. Paul T. Manna, 

Andrew J. Smith, Tarvinder K. Taneja, Sarah Fletcher, Jonathan D. Lippiat, 

Asipu Sivaprasadarao. 

Nucleocytoplasmic Transport (Boards #B422–#B423) 


Probing Nucleocytoplasmic Transport with Fluorescence Fluctuation 

Spectroscopy and Two-photon Activation of Photoactivable GFP. 

Yan Chen, Bin Wu, Joachim Mueller. 


Discontinous Movement Of mRNPs In Nucleoplasmic Regions Devoid Of 

Chromatin. Jan Peter Siebrasse, Roman Veith, Akos Dobay, 

Heinrich Leonhardt, Bertil Daneholt, Ulrich Kubitscheck. 

Ryanodine Receptors Type I (Boards #B424–#B442) 


Structural Characterization of FKBP Interactions with RyR Channels Using 

Site-Directed Fluorescent Labeling and FRET. Razvan L. Cornea, 

Florentin Nitu, Katherine Kohler, David D. Thomas, Bradley R. Fruen. 


Mapping the Ryanodine Receptors Pore Region Using the Substituted 

Cysteine Accessibility Method. Albano C. Meli, Ran Zalk, Anetta Wronska, 

Arthur Karlin, Andrew R. Marks. 


A FRET-based Assay To Measure Molecular Distances Within The Ryanodine 

Receptor Type 1 (RyR1). James D. Fessenden. 


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Ryanodine Receptor Pore Structure and Function. Srinivas Ramachandran, 

Adrian W. R. Serohijos, Le Xu, Gerhard Meissner, Nikolay V. Dokholyan. 


Characterization of Conformation-Specific Monoclonal Antibodies Against 

Skeletal Ryanodine Receptor. Tishan Williams, Ran Zalk, Susan Morton, 

Filippo Mancia, Andrew R. Marks. 


Homer-RyR1 Associations Are Physiological Regulators Of Intracellular 

[Ca21]. Jose Miguel Eltit, Wei Feng, Paul Worley, P. D. Allen, 

Jose Rafael Lopez, Isaac N. Pessah. 


Mitsugumin 29 as a TRPC3-interacting Protein. Ji-Hye Hwang, 

Jin Seok Woo, Chung-Hyun Cho, Eun Hui Lee. 


Cross-Reactivity of Ryanodine Receptors with Putative Modulators of Ion 

Channels in the Plasma Membrane. Jake T. Neumann, Julio A. Copello. 


The Na 1 /ca 21 Exchanger Inhibitor Kb-r7943 Is Also A Potent Inhibitor Of Ec 

Coupling And Ryanodine Receptors. Genaro Barrientos. 


Dust From Pig Confinement Facilities Bind To And Activate Skeletal Muscle 

Ryanodine Receptor Calcium-Release Channel (RyR1). Chengju Tian, 

Danielle S. Fenster, Mark M. Mixan, Myron Toews, Deborah J. Romberger, 

Keshore R. Bidasee. 


Ryanodine Receptor Phosphorylation By Protein Kinase A Alters The Affinity 

For FKBP12. Julia Griffiths, Jonathan-Lee Jones, F. Anthony Lai, 

Lynda Blayney. 


Muscle From Mice Heterozygous For A Mutation That Abolishes FKBP12 

Binding To RyR1 Fatigue More Slowly Than Wildtype Muscle. 

Jianjun Xu, Ruirui Ji, Cheng Long, William Durham, Qing Cheng, Keke 

Dong, Guojun Yang, Susan L. Hamilton. 


S165F Mutation In Junctophilin-2 Affects Phosphorylation And Ca 21 

Signaling In Skeletal Muscle. Jin Seok Woo, Ji-Hye Hwang, Jae-Kyun Ko, 

Noah Weisleder, Do Han Kim, Jianjie Ma, Eun Hui Lee. 


Independent Actions Of Junctin And Triadin On Skeletal Muscle RyR1 

Channels. Lan Wei, Esther M. Gallant, Nicole A. Beard, Angela F. Dulhunty. 


Does Altered Retrograde Coupling Between and RyR1 and the DHPR 

Contribute to Malignant Hyperthermia? . Roger A. Bannister, Jose R. Lopez, 

Paul D. Allen, Kurt G. Beam. 


Understanding The Molecular Defects Of Human MH And CCD. 

Andrea Koop, Wenqian Chen, Ruiwu Wang, Jeff Bolstad, Lin Zhang, 

S.R. Wayne Chen. 


S-nitrosylated Cysteins In The Y522S Ca21 Release Channel RyR1. 

Dimitra K. Georgiou, Aditya D. Joshi, Paula Aracena-Parks, Guojun Yang, 

Susan L. Hamilton. 


Clues to the Formation of Cores in a Mouse Model of Malignant 

Hyperthermia. Simona Boncompagni, Ann E. Rossi, Susan L. Hamilton, 

Robert T. Dirksen, Clara Franzini-Armstrong, Feliciano Protasi. 


Carbohydrate Metabolism and Sudden Death In Mice Heterozygous for the 

Y524S Mutation in RyR1. Qing Cheng, Cheng Long, William J. Durham, 

Susan L. Hamilton. 

Ryanodine Receptors Type II (Boards #B443–#B464) 


Relocation of Calmodulin in Hypertrophic Neonatal Cardiomyocytes. 

Jaya Gangopadhyay, Tomoyo Hamada, Noriaki Ikemoto. 



Endurance Training Abolish Arrhythmogenic Ca21 Leak In Cardiomyocytes 

From Mice Over-expressing CaMKII. Tomas O. Stølen, 

Morten A. Høydal, Joan H. Brown, Lars S. Maier, Godfrey L. Smith, 



Ca 21 -calmodulin Increases RyR2 Open Probability Yet Reduces Ryanoid 

Association With RyR2. Charalambos Sigalas, Belen Bayo-Martin, David Jane, 

Rebecca Sitsapesan. 


Phosphorylation Activates RyR2 By Uncoupling The Channel From The 

Influence Of Cytosolic Ca 21 But Also Inhibits RyR2 By A Distinct 

Mechanism. Simon Carter, Rebecca Sitsapesan. 


FKBP12.6 Overexpression Blunts Cardiomyocyte Remodeling After Leftventricular 

Pressure-overload. Liesbeth Biesmans, Virginie Bito, Laurent Vinet, 

Patricia Rouet-Benzineb, Jean-Jacques Mercadier, Karin Sipido. 


FKBP12.6 Binding Characteristics of Ryanodine Receptor Mutations 

Associated with Arrhythmogenic Cardiac Disease. Spyros Zissimopoulos, 

N. Lowri Thomas, F. Anthony Lai. 


Impact of RyR2 Mutation Responsible for Cathecolaminergic Polymorphic 

Ventricular Tachycardia (CPTV) on the Short Term Interval-Force 

Relationship of Atrial and Ventricular Myocardium. Cecilia Ferrantini, 

Raffaele Coppini, Beatrice Scellini, Alexandra Belus, Chiara Tesi, 

Barbara Colombi, Elisabetta Cerbai, Carlo Napolitano, Silvia Priori, 

Corrado Poggesi. 


An L433P Arrhythmia-linked Mutation In RyR2 Uncouples Agonist-evoked 

Ca 21 Release From Homeostatic Ca 21 Cycling. Aaron I. Clack, Debra L. Fry, 

N. Lowri Thomas, F. Anthony Lai, Christopher H. George. 


A G1885E RyR2 Polymorphism Modulates The Caffeine Sensitivity Of An 

Arrhythmia-linked Mutation. Aaron I. Clack, N. Lowri Thomas, 

Christopher H. George, F. Anthony Lai. 


Decoding The Molecular Basis Of Anti-Apoptotic Cardiac Ca 21 Signalling Via 

Human RyR2 Splice Variants. Wai Yin Yeung, Matthew Davies, 

F. Anthony Lai, Alan J. Williams, Christopher H. George. 


Use Of Shaker B K 1 Channel NH2-inactivation Peptides To Probe The 

Ryanodine Receptor Ca 21 Release Channel Pore. Cedric Viero, Jo Carney, 

Sammy Mason, Mark Bannister, S R. Chen, Alan J. Williams. 


Imperatoxin A, A Calcin Toxin From Pandinus Imperator Scorpions, Ablates 

Calcium Sparks In Permeabilized Cells. Erin M. Capes, Hector H. Valdivia. 


Block Of Mouse Cardiac Ryanodine Receptor (mRyR2) By hERG Blocking 

Agents. Sammy A. Mason, Wayne S.R. Chen, Alan J. Williams. 


Cardiac Ca21 Release Channel/RyR2 -Molecular Mechanism Of Green Tea 

Extract epigallocatechin-3-gallate. George G. Rodney, Elaine Cabrales, 

Isaac N. Pessah, Wei Feng. 


Voltage-Dependent Modulation of Cardiac Ryanodine Receptors (RyR2) by 

Protamine. Paula L. Diaz-Sylvester, Julio A. Copello. 


SAM Regulation of RyR2. Angela J. Kampfer, Edward M. Balog. 


Targeted Stabilisation Of The RyR2 I-Domain Restores Ca 21 Handling And 

Intercellular Synchrony In Ouabain-disrupted Cardiac Cell Monolayers. 

Hala Jundi, F. Anthony Lai, Christopher H. George. 


The Effect of Volatile Anaesthetics on the Cardiac Ryanodine Receptor. 

Derek R. Laver, Tony Quail, Holly Sitsapesan, Dirk F. VanHelden. 


Iron (II) Modulation of the Cardiac Ryanodine Receptor (RyR2). 

Daniel T. Baptista-Hon, Austin C. Elliott, Mary E. Diaz. 

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Increased Expression of Ryanodine Receptors and the Iron Transporter DMT1 

in Hippocampal Neurons by Brain Derived Neurotrophic Factor (BDNF), 

NMDA or Spatial Memory Training. Paola Haeger, Tatiana Adasme, 

Pablo Munoz, Alexis Humeres, M. Angelica Carrasco, Marco T. Nunez, 

Cecilia Hidalgo. 


Increased Levels Of Type 2 Ryanodine Receptor (RyR2) In Rat Heart 

Mitochondria During Diabetes. Ming Li, Aydin Tay, Gisela Beutner, 

Wenjun Ding, Shey-Shing Sheu, Keshore Bidasee. 


Intracellular Calcium Release Channels Mediate Their Own Countercurrent: 

The Ryanodine Receptor Case Study. Dirk Gillespie, Michael Fill. 

32 

Calcium Signaling Proteins (Boards #B465–#B484) 


Essential Roles for Coiled-coil Domains in STIM1 Oligomerization and 

CRAC Channel Activation. Elizabeth D. Covington, Richard S. Lewis. 


Atomic Force Microscopy of Copine I and Annexin A1 on Supported 

Phospholipid Bilayers: Structure and Synergism. Carl E. Creutz, 

J. Michael Edwardson. 


Depletion Of Intracellular Cholesterol Disrupts Carbachol But Not PTH-mediated 

Ca 21 Signals In HEK293 Cells. Stephen C. Tovey, Colin W. Taylor. 


Increased Store-Operated Ca21 Entry in Skeletal Muscle with Knockdown of 

Calsequestrin. Choon Kee Min, Xiaoli Zhao, Jae-kyun Ko, Zui Pan, 

Jerome Parness, Do Han Kim, Noah Weisleder, JIanjie Ma. 


Role of the Ryanodine Receptor/Calcium Release Channel in Beta-adrenergic 

Receptor Blocker Treatment of Heart Failure. Jian Shan, Steve Reiken, 

Miroslav Dura, Albano Meli, Marco Mongillo, Andrew R. Marks. 


Structural Basis for Calcium Sensing by GCaMP2. Qi Wang. 


Interference In Coiled-coil Mediated Coupling Between Stim1 And Orai 

Channels. Judith Bergsmann, Irene Frischauf, Martin Muik, Isabella Derler, 

Marc Fahrner, Klaus Groschner, Christoph Romanin. 


An Orai1 Activating Minimal Fragment Of Stim1. Martin Muik, 

Marc Fahrner, Isabella Derler, Rainer Schindl, Irene Frischauf, 

Judith Bergsmann, Reinhard Fritsch, Josef Madl, Klaus Groschner, 

Christoph Romanin. 


Increased Hydrophobicity At The N-terminus/membrane Interface Impairs 

Gating Of The Scid-related Orai1 Mutant. Isabella Derler, Marc Fahrner, 

Oliviero Carugo, Martin Muik, Judith Bergsmann, Rainer Schindl, 

Irene Frischauf, Said Eshaghi, Christoph Romanin. 


Structural dynamics of CaMKII activation. Laurel Hoffman, 

Hassane S. Mchaourab. 


Calcium binding and conformational properties of calmodulin complexed 

With PEP-19. Xu Wang, Quinn Kleerekoper, John Putkey. 


Characterization of Calmodulin with Mutated Ca21-Binding Sites. 

Liangwen Xiong, Quinn Kleerekoper, John Putkey. 


Interactions of the Anti-Psychotic Drug Trifluoperazine with Calmodulin. 

Michael D. Feldkamp, Madeline A. Shea. 


Integration of Extracellular and Intracellular Calcium Signals via Calcium- 

Sensing Receptor (CaSR). Yun Huang, Yubin Zhou, Adriana Castiblanco, 

Hing-Cheung Wong, Yangyi Chen, Wei Yang, Edward M. Brown, 

Jenny J. Yang. 


Altered Calcium Handling Between Healthy And Atherosclerotic Vascular 

Smooth Muscle. Marie-Ann Ewart, Susan Currie, John G. McCarron, 

Simon Kennedy. 


PEP-19 is an Intrinsically Disordered, Acidic/IQ Motif Regulator of 

Calmodulin Signaling. Quinn K. Kleerekoper, Liangwen Xiong, Xu Wang, 

John A. Putkey. 


Preferential Binding and Orientation of Recoverin to Phospholipid 

Monolayers. Philippe Calvez, Julie Boucher, Philippe Desmeules, 

Christian Salesse. 


Characterization Of Ca 21 Photo-release From DM-nitrophen Using 

Photothermal Beam Deflection. Gangadhar Dhulipala, Jaroslava Miksovska. 


Altered Structure Of The Cerebellar Granule Cell Layer Of Mice Lacking 

Calretinin. Patrick Bischop, Céline Roussel, Serge Schiffmann, David Gall. 


Characterization Of Zebrafish (Danio Rerio) NCX4: A Novel Na/Ca 

Exchanger With Distinct Electrophysiological Properties. Glen F. Tibbits. 

Calcium Signaling Pathways (Boards #B485–#B503) 


Modeling [Na1] in PM-SR Nanodomains of Vascular Smooth Muscle Cells. 

Nicola Fameli, Cornelis van Breemen. 


A 3d Pseudo-stochastic Model Of Intercellular Calcium Signaling In Smooth 

Muscle. Dumitru A. Iacobas, Sylvia O. Suadicani, David C. Spray. 


Increased Sensitivity to Ischemia in an Early Diabetic Cardiomyopathy: The 

Role of Calcium Handling. Natale P L Rolim, Charlotte B. Ingul, 

Harald E M Hansen, Tomas Stølen, Morten Høydal, Anne Berit Johnsen, 



Calcium Induced Conformational Changes In The Cytoplasmic Tail Of 

Polycystin-2. Edward T. Petri, Andjelka S. Celic, Titus J. Boggon, 

Barbara E. Ehrlich. 


L163,255, a Synthetic Growth Hormone Secretagogue, Raises [Ca21 ]i by 

Promoting Intracellular Calcium Stores Depletion in Intact Fast-Twitch Fibers 

of Rat Skeletal Muscle. Antonella Liantonio, Viviana Giannuzzi, 

Gianluca Gramegna, Diana Conte Camerino. 


Multiple Sources of Light-Evoked Intracellular Calcium Increases in 

Hermissenda Type B Photoreceptors. Joseph Farley, Joel Cavallo, 

Brent Hallahan, Jeff Johnson. 


Chromophore Formation of Fluorescence Proteins and Its Application of 

Developing Ca21 Sensors. Jin Zou, Malcom Delgado, Yun Huang, 

Shen Tang, Yusheng Jiang, Blein McIntyre, Anne Wang, Jenny J. Yang. 


Orai1 Channel And Ca21-independent Phospholipase A2 Are The New 

Determinants Of Proliferation And Migration Of Vascular Smooth Muscle 

Cells. Bo Yang, Victoria M. Bolotina. 


Complexity Of Relationship Between STIM1, iPLA2b And Orai1 Expression, 

Puncta Formation And SOCE Activation In Native And Heterologous 

Systems. Tomasz Gwozdz, Joanna Dutko-Gwozdz, Vladislav Zarayskiy, 

Victoria M. Bolotina. 


Membrane Depolarization of Skeletal Muscle Cells Induces IL6 and SOCS3 

mRNA Expression Through Calcium Dependent Stat3 Phosphorylation. 

Mario A. Bustamante, Jose M. Eltit, Manuel Estrada, Enrique Jaimovich. 


Isoproterenol-Enhanced Diastolic Sarcoplasmic Reticulum Ca Leak in 

Ventricular Myocytes Requires Activation of Nitric Oxide Synthase. 

Jerry Curran, Usama Ahmed, Donald M. Bers, Mark Ziolo, 

Thomas R. Shannon. 


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Discrete Proteolysis Of Neuronal Calcium Sensor 1 By m -calpain Disrupts 

Calcium Binding. Courtney R. Blachford, Andjelka S. Celic, 

Edward T. Petri Jr, Barbara E. Ehrlich. 


Effect Of (-)-epigallocatechin Gallate (EGCG), A Green Tea Extract, On 

Excitation-contraction Coupling Of Murine Cardiomyocytes. 

Hyun Seok Hwang, Wei Feng, Tao Yang, Isaac N. Pessah, 

Bjorn C. Knollmann. 


Properties and Functions of Store-Operated Calcium Entry in the Developing 

Nervous System. Agila Somasundaram, Murali Prakriya. 


Investigating the Architecture of the CRAC Channel Pore using SCAM. 

Beth McNally, Murali Prakriya. 


Both Membrane Depolarization And IL-6 Induce Calcium-Dependent Hsp70 

Expression In Skeletal Muscle Cells. Gonzalo Jorquera, Nevenka Juretic, 

Alejandra Espinosa, Enrique Jaimovich, Nora Riveros. 


Ryanodine receptor 1 signaling in dendritic cells. Mirko Vukcevic, 

Giulio C. Spagnoli, Giandomenica Iezzi, Francesco Zorzato, Susan Treves. 


Understanding Interval-Force Relations in the Rat Ventricular Myocytes with a 

Computational Model. Ryosuke Kadoi, Sameer Bajikar, Mohsin S. Jafri. 


Ca11T LAB - A Computational Model for Intracellular Calcium Signaling In 

T Lymphocytes. Rayhan Lal, Jose L. Puglisi, Heike Wulff, Donald M. Bers. 

Actin & Actin-binding Proteins (Boards #B504–#B526) 


Actin Branching Is Affected by Local Bending of the Mother Filament. 

Viviana Risca, Ovijit Chaudhuri, JiaJun Chia, Daniel A. Fletcher. 


Mechanics of Biophysical Networks with Flexible Cross-links. 

Goran Zagar, Patrick R. Onck, Erik Van der Giessen. 


Intracellular Particles Involved in Stress Fiber Formation through Remodeling 

of Actin Filament Networks. Kazushi Tamura, Takeomi Mizutani, 

Hisashi Haga, Kazushige Kawabata. 


Purification Of Cytosolic Actin By Affinity Chromatography Using C-terminal 

Half Of Gelsolin. Takashi Ohki, Koutarou Ohyama, Shin’ichi Ishiwata. 


Actin Polymerization In Differentiated Vascular Smooth Muscle Cells Requires 

Vasodilator-Stimulated Phosphoprotein (VASP). HakRim Kim, 

Francois Ferron, Malgorzata Boczkowska, Philip Graceffa, Cynthia Gallant, 

Paul Leavis, Roberto Dominguez, Kathleen G. Morgan. 


Actin - Myosin Interaction. Cynthia N. Prudence, Jim Segala, 

Vladislav Markin, Yana Reshetnyak, Oleg Andreev. 


A Thermodynamic Model Describing the Mechanosensitivity of Actin-cofilin 

Binding. Yasuhiro Inoue, Taiji Adachi, Masaki Hojo. 


Slow skeletal muscle actin. Robert C. C. Mercer, Wasana A.K.A. Mudalige, 

David H. Heeley. 


Binding Studies Between Cofilin And Actin Using Fluorescence Resonance 

Energy Transfer And Molecular Modeling. Joo-Mee Hwang, Deepak Chhabra, 

Murat Kekic, Piotr G. Fajer, Brett D. Hambly. 


Starting Actin Filaments Anew - Adenomatous Polyposis Coli Is an Actin 

Nucleator. Kyoko Okada, Alexandra M. Deaconescu, James B. Moseley, 

Zvonimir Dogic, Nikolaus Grigorieff, Bruce L. Goode. 



Measuring Molecular Interaction between Actin Filament and Actin Binding 

Protein Governing Mechanical Properties of Cross-Linked F-Actin Network. 

Hyungsuk Lee, Benjamin Pelz, Jorge M. Ferrer, Fumihiko Nakamura, 

Roger D. Kamm, Matthew J. Lang. 


Interaction of CapZ with Actin: Molecular Mechanism and Regulation. 

Taekyung Kim, John A. Cooper. 


Structural Binding Model of Cofilin and F-actin. Diana Y. Wong, David Sept. 


Energy Coupling In Profilin-Dependent Actin Polymerization. 

Elena G. Yarmola, Dmitri A. Dranishnikov, Michael R. Bubb. 


Computational Study Of Viscoelasticity Of Crosslinked Actin-like Networks. 

Taeyoon Kim, Wonmuk Hwang, Hyungsuk Lee, Roger D. Kamm. 


Weak to Strong Transition at the Actin-Myosin Interface Detected by 

Sensitized Emission Luminescence Resonance Energy Transfer (SELRET). 

Piyali Guhathakurta, Ewa Prochniewicz, David D. Thomas. 


Crystal Structures of Monomeric Actin Bound to Cytochalasin D. 

Usha B. Nair, Peteranne B. Joel, Qun Wan, Susan Lowey, Mark A. Rould, 

Kathleen M. Trybus. 


Structure of an Actin Trimer Stabilized by a Tandem W Domain Hybrid 

Construct. Grzegorz Rebowski, Malgorzata Boczkowska, David B. Hayes, 

Liang Guo, Thomas C. Irving, Roberto Dominguez. 


Finite Element and Statistical Methods Applied to Actin Bundles and 

Networks under Load. Chia-Cheng Liu, Esfandiar A. Khatiblou, 

Tess J. Moon. 


Different Types Of Polymorphisms Within The F-actin And ParM Filaments. 

Vitold E. Galkin, Albina Orlova, Ethan C. Garner, R Dyche Mullins, Edward 

H. Egelman. 


The Effect of Actin-Binding Proteins on the Dynamics of Monomeric Actin. 

Gábor Hild, Roland Kardos, Miklós Nyitrai, Elisa Nevalainen, Pekka 

Lappalainen. 


Computational Analysis of the Interaction Between Paired CH-Domains - 

Implications for their F-actin Bound Conformations. Kevin C. Facemyer, 

Roberto Dominguez, Christine R. Cremo, William J. Lehman. 


Molecular Dynamics Simulation Reveals The Role Of Cross-linkers In Semiflexible 

Filament Assembly. Lam T. Nguyen, Wei Yang, Linda S. Hirst. 

Actin-binding Proteins in Physiology & Disease 

(Boards #B527–#B543) 


Structure Function Analysis of Disease-Causing Missense Mutations in 

Dystrophin. Davin M. Henderson, James M. Ervasti. 


Computational modeling of the binding interaction of Jasplakinolide and 

Phalloidin with mammalian and parasite F-actin. Karthikeyan Diraviyam, 

David Sept. 


Vinculin Expression Regulates Tumor Cell Invasion In 3-D Matrices. 

Claudia T. Mierke, Wolfgang H. Goldmann. 


Role of Nebulin on Actomyosin Interaction Studied in situ in Demembranated 

Skeletal Muscle Fibers from Newborn Mice. M.L. Bang, M. Caremani, 

E. Brunello, R. Littlefield, R. Lieber, J. Chen, V. Lombardi, M. Linari. 


Tropomyosin Specifically Regulates Type II Myosin In Yeast. 

Arthur T. Coulton, Daniel P. Mulvihill. 

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Neurospora Crassa possesses a novel ultra short tropomyosin. 

Seham Ebrahim, Robin Maytum. 


Multiple Isoforms of Fesselin (Avian Synaptopodin 2) are expressed in Smooth, 

Skeletal and Heart Muscle. Mechthild M. Schroeter, Daniel Hurley, J 

oseph M. Chalovich. 


A Mechano-kinetic Model For The Myosin-V Walking Mechanism. 

Erin M. Craig, Heiner Linke. 


Regional Variations in Flexibilities Limit Continuum Rod Description of Long 

Coiled Coils. Sirish K. Lakkaraju, Wonmuk Hwang. 


The Striated Organelle: A Molecular Motor In Vestibular Type I Hair Cells. 

Anna Lysakowski, Florin Vranceanu. 


Dystrophin and Utrophin have Distinct Effects on the Microsecond Dynamics 

of Actin. Ewa Prochniewicz, Davin Henderson, Ava Yun Lin, James Ervasti, 

David D. Thomas. 


Myosin-induced Movement Of Tropomyosin Isoforms On Actin Filament. 

Joanna Moraczewska, Malgorzata Séliwinéska, Magdalena ˙ Zukowska, Danuta 

Borys. 


Interactions of the Pleckstrin Homology Domains of M-RIP (p116Rip) with 

F-actin. Ana M. Garcia, Terence C. Tao. 


bCaMKII Regulates Actin Assembly and Structure. Hugo Sanabria, 

Kolodziej J. Steven, Matthew T. Swulius, Jun Liu, M. Neal Waxham. 


Coactosin, A Cofilin Like Protein, Does Not Change The Twist of F-actin. 

Albina Orlova, Vitold E. Galkin, Pekka Lappalainen, Edward H. Egelman. 


Conformational Changes Of Arp2/3 Complex During Activation. 

Paul Dalhaimer, Thomas D. Pollard. 


Acidic Calponin controls ERK1/2 translocation and l-Caldesmon phosphorylation 

in fibroblasts. Sarah Appel, J.-P. Jin, Kathleen G. Morgan. 

Cytoskeletal Protein Dynamics & Intracellular Cargo 

Transport (Boards #B544–#B564) 


The Pro-apoptotic Protein Par-4 Regulates Myosin Light Chain 

Phosphorylation By Activating Myosin Phosphatase Activity. 

Susanne Vetterkind, Eunhee Lee, Eric J. Sundberg, Terence C. Tao, Ute 

Preuss, Kathleen G. Morgan. 


Microinjection of Smooth Muscle Myosin in Cultured Cells. 

Katherine McDonald, Renaud Leguillette. 


Essential Features of a Non-processive Class V Myosin from Budding Yeast for 

ASH1 mRNA Transport. Carol S. Bookwalter, Matthew Lord, 



Towards Custom-topology Tracks For Probing Myosin Motor Dynamics. 

Hendrik Dietz, Nathan D. Derr, Alex Dunn, James A. Spudich, 

William M. Shih. 


An Open Model of Actin Dendritic Nucleation. Leslie M. Loew, Igor L. 

Novak, Jonathon A. Ditlev, Nathaniel M. Vacanti. 


Real-time Observation Of Actin Polymerization Regulated By The Gelsolinfamily 

Of Proteins. Balakrishnan Kannan, Robert C. Robinson. 


Computational Modeling of Antigen Processing and Presentation by Dendritic 

Cells. Kenny K. Tran, Hong Shen. 

34 


Regulation and single-molecule mechanics of microtubule-based motors in living 

Chlamydomonas. Jeneva A. Laib, Robert A. Bloodgood, 

William H. Guilford. 


Multiple-Motor-Based Transport. Ambarish Kunwar, Alex Mogilner. 


Transport Of Micrometer-Sized Vesicles By Kinesin In Vitro. 

Christoph Herold, Cécile Leduc, Eugene P. Petrov, Stefan Diez, 

Petra Schwille. 


Intermittent Search Strategies for Delivering mRNA to Synaptic Targets. 

Jay Newby. 


Microtubule elasticity: Connecting all-atom simulations with continuum 

mechanics. David Sept, Fred MacKintosh. 


Extending the Range of In Vivo Multimotor Force-Velocity Curves by Sizing 

Vesicles Below the Diffraction Limit. Jed C. Macosko, Yuri Shtridelman, 

Clayton T. Bauer, David DeWitt. 


Characterizing Intracellular Structure and Dynamics Through Trajectory 

Analysis and Single-particle Tracking of QDs in Live PC12 Cells. 

Brian R. Long, Tania Q. Vu. 


High Resolution Live-Cell Imaging Reveals Novel Pathways for Lysosomal 

Delivery. Zhuo Gan, Sripad Ram, Carlos Vaccaro, Raimund J. Ober, 

E. Sally Ward. 


Microfluidic Investigation Reveals Distinct Roles for Actin Cytoskeleton and 

Myosin II Activity in Capillary Leukocyte Trafficking. Sylvain Gabriele, Anne- 

Marie Benoliel, Pierre Bongrand, Olivier Theodoly. 


CD2AP Structure And Progression Of Renal Disease. Brian D. Adair, 

Mehmet Altintas, Clemens C. M ller, Jan Flesche, Changli Wei, 

Christian Faul, Kirk Campbell, Changkyu Gu, Sanja Sever, Andrey Shaw, 

Peter Mundel, Jochen Reiser. 


Prestress-dependent Rheology of Semiflexible Polymers of the Cytoskeleton. 

Arnab Majumdar, Noah Rosenblatt, Adriano M. Alencar, Bela Suki, 

Dimitrije Stamenovic. 


Straining the Laws of Attraction: Mechanotransduction Studied Through 

Changes in Intracellular Binding Energy. Nur Aida Abdul Rahim, 

Mohammad R K Mofrad, Peter T C So, Roger D. Kamm. 


Salt Dependence of Neurofilament Gel Phase Behavior - A Synchrotron X-ray 

Scattering Study. Joanna Deek, Jayna Jones, Roy Beck, Cyrus R. Safinya. 


Multi-Parameter Analysis of Spindle and Cell Cycle Dynamics in Asymmetric 

Cell Division. Kemp W. Plumb, Vincent Pelletier, Susi Kaitna, Jackie Vogel, 

Maria L. Kilfoil. 

Microtubular Motors I (Boards #B565–#B590) 


Synthesis Of Novel Fluorescent Atp Analogue And Interaction With 

Nucleotide Dependent Motor Proteins. Taro Kimura, Masafumi Yamada, 

Masato Ito, Shinsaku Maruta. 


Photo-activation Of Atpase Activity Of Caged-kinesin. Yuki Takano, 

Kazuya Aritomi, Masafumi D. Yamada, Shinsaku Maruta. 


Interaction of Processive Motor Proteins with ATP analogue Having Syn 

Conformation with respect to the Adenine-ribose bond. Kazuhiro Kawanoue, 

Shigeru Chaen, Shinsaku Maruta. 


Photo-regulation of Kinesin ATPase Activity using Photochromic Molecule. 

Takeshi Itaba, Masahumi D. Yamada, Shinsaku Maruta. 


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Photo-control Of Atpase Activity Of The Kinesin Motor Domain 

Intermolecularly Cross-linked By Bifunctional Photochromic Compound. 

Eiichi Kobayashi, Masafumi Yamada, Masato Ito, Shinsaku Maruta. 


Processive Motility of Heterodimeric Kinesin That Has Defect in the Neck 

Linker Docking. Teppei Mori, Michiko Nakajima, Michio Tomishige. 


Configuration Of The Kinesin1 Motor Domains In The ATP-waiting State As 

Revealed By Fluorescence Polarization Microscopy. Ana Asenjo, 

Hernando J. Sosa. 


Cooperative Movement Of Wild-type Kinesin And Velocity-deficient Mutants. 

Adam G. Larson, Eric C. Landahl, Sarah E. Rice. 


Kinesin Chimera Protein Fused with Calmodulin as a Molecular Shuttle. 

Kiyoshi L. Nakazato, Hideki Shishido, Kazuhiro Kawanoue, 

Shinsaku Maruta. 


Evidence For Kinesin-1 Passing Obstacles On The Microtubule. 

Ivo A. Telley, Peter Bieling, Thomas Surrey. 


Unique Conformation of Kinesin-1’s Neck Linker in the Nucleotide-free State. 

Tsukasa Makino, Michio Tomishige, Masahide Kikkawa. 


Examination Of The Kinesin-1 Tail Interaction With Microtubules. 

Mark Seeger, Paul Brewer, Cristine Cremo, Sarah Rice. 


Location of Tethered Head of Kinesin-1 When Bound to a Microtubule. 

David D. Hackney. 


How Occasional Backstepping Can Speed Up A Processive Motor Protein. 

Martin Bier. 


How Does Kinesin Walk And Coordinate Its Heads?. 

Imre Derenyi, Andras Czovek, Gergely J. Szollosi. 


Molecular Simulation Study of Kinesin: Coupling between ATPase Domain 

Conformational Change and Mechanical Stepping. Ryo Kanada, 

Kei-ichi Okazaki, Shoji Takada. 


SRAA POSTER 

The Kinesin-1 Tail Conformationally Restricts the Nucleotide Pocket. 

Yao Liang Wong, Kristen A. Dietrich, Nariman Naber, Roger Cooke, 

Sarah E. Rice. 


Kinesin Velocity Increases with the Number of Motors in Gliding Assays 

against a simple Viscoelastic Load. George Holzwarth, Jason Gagliano, 

Matthew Walb, Jed C. Macosko. 


Quantum-dot Assisted Characterization Of Helical Motor Paths On 

Microtubules. Bert Nitzsche, Felix Ruhnow, Stefan Diez. 


Diffusive Movement Of A Processive Kinesin On Microtubules. 

Hailong Lu, Yusuf M. Ali, Carol S. Bookwalter, David M. Warshaw, 



Alternating Site Mechanism Of Kinesin-1 Characterized By Single-molecule 

FRET Of Fluorescent ATP Analogues. Guenther Woehlke, 

Sander Verbrugge, Bettina Ebbing, Erwin Peterman. 


Expression and Characterization of Novel Rice Kinesin E15. 

Masako Tsuchida, Masafumi D. Yamada, Kazunori Kondo, Shinsaku Maruta. 


Kinetic characterization of the Rice Kinesins using Fluorescent-ATP Analogue. 

Nozomi Umezu, Yuko Kubo, Kazunori Kondo, Toshiaki Mitsui, 




Analysis of Crystal Structure and Solution Structure of the Motor Domain of 

Rice Kinesin K16. Shinsaku Maruta, Keiko Tanaka, Yuko Kubo, 

Toshiaki Mitsui, Zui Fujimoto. 


Analysis of Conformational Change of Novel Rice Kinesin K16 Using Small 

Angle X-ray Solution Scattering and EPR. Yuko Kubo, Satoshi Yasuda, 

Yasunobu Sugimoto, Masafumi D. Yamada, Toshiaki Arata, Katsuzo 

Wakabayashi, Shinsaku Maruta. 


The Effect Of Loads on the Collective Behavior of Neurospora Kinesin. 

Adam G. Hendricks, Bogdan I. Epureanu, Edgar Meyhofer. 

Unconventional Myosins (Boards #B591–#B613) 


Photo-Control of Myosin Va using Photoresponsive Calmodulin. 

Hideki Shishido, Nobuhisa Umeki, Osamu Sato, Mitsuo Ikebe, 



Modification Of Loop 1 Affects The Nucleotide-Binding Properties Of 

Myo1c, The Adaptation Motor In The Inner Ear. Nancy Adamek, 

Alena Lieto-Trivedi, Sheffali Dash, Michael A. Geeves, Lynne M. Coluccio. 


Mechanics of myosin V near stall. Claudia Veigel, James R. Sellers. 


Force Dependence of a Myo1b Truncation Mutant. Joseph M. Laakso, 

Henry Shuman, E. Michael Ostap. 


Single-molecule Measurements Of Myo1c-PIP2 Detachment Forces Using 

Optical Tweezers. Serapion Pyrpassopoulos, Henry Shuman, 

E. Michael Ostap. 


High Speed Imaging For Myosin VI. Ikuo Arimoto, So Nishikawa, 

Mitsuhiro Sugawa, Atsuko H. Iwane, Toshio Yanagida. 


Temperature Dependent Energy Transfer Measurements Reveal Flexibility in 

the Upper 50 kDa Domain of Myosin V. Darshan Trivedi, Charles David, 

Michael Rose, Donald J. Jacobs, Christopher Yengo. 


Kinetics Of Myo1c Association To And Dissociation From Phosphoinositidecontaining 

Vesicles. Jennine M. Dawicki McKenna, E. Michael Ostap. 


Single Molecule Investigation of the Acto-Myosin-10 Complex Using Optical 

Tweezers. Yasuharu Takagi, Rachel E. Farrow, Gregory I. Mashanov, 

Christopher Batters, Yi Yang, Michelle Peckham, James R. Sellers, 

Justin E. Molloy. 


Bayesian Estimation for Hidden Information of a Single Molecular Motor. 

Makito Miyazaki, Takahiro Harada. 


ADP Affinity of Myosin VI is Regulated by Off-Axis Load. 

Sergey Mikhailenko, Yusuke Oguchi, Adrian O. Olivares, 

Enrique De La Cruz, Shin’ichi Ishiwata. 


The Tail Binds To The Head-Neck Domain To Form A Folded-Back 

Conformation That Inhibits The Actin-Activated ATPase Activity Of 

Drosophila Myosin VIIA. Nobuhisa Umeki, Hyun Suk Jung, 

Shinya Watanabe, Tsuyoshi Sakai, Xiang dong Li, Reiko Ikebe, Roger Craig, 

Mitsuo Ikebe. 


The Medial-tail Domain of Myosin-VI as a Dimerization Region. 

Hyeongjun Kim, Monalisa Mukherjea, H. Lee Sweeney, Paul R. Selvin. 


Processivity of Myosin V and X on two-dimensional (2D) paracrystalline actin 

array. Daniel Huck, Abhishek Roka, Jim Sellers, Takeshi Sakamoto. 


Cargo-mediated dimerization of Myosin VI. Denis Phichith, Mirko Travaglia, 

Zhaohui Yang, Allan B. Zong, Daniel Safer, Clara Franzini-Armstrong, 

Hugh Lee Sweeney. 

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Characterization of drosophila myosin 7a mechanics. Verl B. Siththanandan, 

Yasuharu Takagi, Yi Yang, Davin K.T. Hong, James R. Sellers. 


Prefoldin 4 (PFD4): A putative new partner of myosin Va (MyoVa) in 

melanosome transport. Renato F. De Paulo, Alistair N. Hume, 

Verônica S. Pinto, Martha M. Sorenson, Miguel M. Seabra. 


The Mechanism of Filament Rotation in Gliding Assays with Non-Processive 

Myosin Motors. Andrej Vilfan. 


SRAA POSTER 

Non-muscle Myosin IIb Is A Processive Actin-based Motor. 

Melanie Norstrom, Ronald S. Rock. 


Lever Arm Length Determines The Azimuthal But Not The Axial Orientation 

Of Myosin V During Processive Motility. John H. Lewis, John F. Beausang, 

H. L. Sweeney, Yale E. Goldman. 


Structural and Mechanistic Determinants of Myosin VI Processivity and 

Anchoring. Peiying Chuan, Alexander R. Dunn, Zev Bryant, 

James A. Spudich. 


Myosin VI Dimerizes And Walks Processively Along Actin. 

Monalisa Mukherjea, Daniel Safer, Julie Ménétrey, Paola Llinas, 

Anne Houdusse, H. Lee Sweeney. 


Cryo-Electron Microscopy of Myosin 5 on Actin. Kavitha Thirumurugan, 

Stan A. Burgess, Fang Zhang, James R. Sellers, Peter J. Knight. 

36 

Ion Motive ATPases (Boards #B614–#B630) 


Kinetic Analysis Of ATP Synthesis Catalyzed By E. coli FoF1 ATP Synthase 

Reconstituted Into Egg Yolk Liposomes: Evidence For Bi-site Activation. 

Mikhail Galkin, Robert K. Nakamoto. 


Ca21 Binding to Site I of the Cardiac Ca21 Pump (SERCA2a) is Sufficient to 

Dissociate Phospholamban (PLB). Zhenhui Chen, Brandy L. Akin, 

Larry R. Jones. 


Concerted but Noncooperative Activation of Nucleotide and Actuator 

Domains of the Ca-ATPase Upon Calcium Binding. Baowei Chen, 

James E. Mahaney, M. Uljana Mayer, Diana J. Bigelow, Thomas C. Squier. 


FRET from SERCA to Phospholamban is Decreased by Thapsigargin and 

Anti-PLB Antibody, but not by Calcium. Philip Bidwell, Daniel J. Blackwell, 

Zhanjia Hou, Seth L. Robia. 


Collapse of TA-Calmodulin (TACaM) upon Binding to Ca 21 Pump Peptide 

C28 Exposes the TA Moiety to Water and Quenches Its Fluorescence. 

John T. Penniston, Ariel J. Caride, Nenad O. Juranic, 

Franklyn G. Prendergast, Elena Atanasova, Adelaida G. Filoteo, 

Emanuel E. Strehler. 


Distinct Regulation of pH in the Cytosol and in Acidic Organelles by a 

Subunit Isoforms of V-ATPase in Human Cancer Cells. Souad R. Sennoune, 

Ayana Hinton, Sarah Bond, Michael Forgac, Raul Martinez-Zaguilan. 


Direct Observation Of Rotation Of F1-Atpase From Saccharomyces cerevisiae 

With mgi Mutations. Bradley C. Steel, Yamin Wang, Vijay Pagadala, 

Richard M. Berry, David M. Mueller. 


Structure Analysis of F1-ATPase via Molecular Dynamics. 

Yuko Ito, Mitsunori Ikeguchi. 


Interplay of Ligand Binding, Domain Interaction and Chaperone Mediated 

Cu 21 Delivery to Cu 21 Transport ATPases. Deli Hong, 

Manuel Gonzalez-Guerrero, Jose M. Arguello. 


Structural Dynamics Of The Phospholamban-SERCA Complex By Site- 

Directed EPR Spectroscopy. Zachary M. James, Kurt D. Torgersen, 

Christine Karim, David D. Thomas. 


Structural Dynamics Of Sarcoplasmic Reticulum Ca21-ATPase (SERCA) 

Studied By Molecular Simulations Of Site-specific Labeled Protein. 

Bengt Svensson, L. Michel Espinoza-Fonseca, David D. Thomas. 


Molecular Dynamics Simulations Reveal Intrinsic Features of SERCA 

Dynamics. L. Michel Espinoza-Fonseca, Bengt Svensson, David D. Thomas. 


Investigation Of Electrogenic Partial Reactions In Detergent-solubilized 

Na,K-ATPase. Michael Habeck, Hans-Juergen Apell. 


Influence of Phosphate Analogs on Palytoxin-opened Na,K-ATPase 

Pump-channel. Ayako Takeuchi, David C. Gadsby. 


Truncation Of The Na/K Pump’s C-terminus Attenuates Voltage-dependent 

Binding Of External Na 1 By Destabilizing Na 1 Occlusion. 

Natascia Vedovato, David C. Gadsby. 


Temporal and Steric Analysis Of Ionic Permeation and Binding in Na1,K1- 

ATPase via Molecular Dynamic Simulations. James E. Fonseca, Savas Kaya. 


Relative Movement Of The a-Subunit’s First And Last External Loops 

Throughout Na/K-Pump Cycle. Pablo Artigas. 

Membrane Transport (Boards #B631–#B647) 


Modeling Osmotic Lysis of Cells by Antimicrobial Peptides: Transient 

Diffusion of Ions and Osmotically-driven Flow. Dan S. Bolintineanu, 

Yiannis N. Kaznessis, H Ted Davis. 


Quantitative Modeling of Passive Permeation through the Blood Brain Barrier. 

Hugo Filipe, Armindo Salvador, Winchil Vaz, Maria Joao Moreno. 

Universidade de Coimbra, Coimbra, Portugal. 


Time-Resolved Studies of Adsorption and Transport of a Hydrophobic Ion at 

Escherichia coli Bacterial Membranes by Second Harmonic Generation. 

Jia Zeng, Heather Eckenrode, Hai-Lung Dai. 


15N Chemical Shift Anisotropy of the Schiff Base in Bacteriorhodopsin 

Intermediates. Melody L. Mak-Jurkauskas, Alexander B. Barnes, 

Yoh Matsuki, Marina Belenky, Robert G. Griffin, Judith Herzfeld. 


Insight on the Diverse Cellular Pathways of Two Novel Chelators from 

Liposome Partition Studies. Maria Rangel, Paula Gameiro, Andreia Leite, 

Ana Nunes, Tao Zhou, Yongming Ma, Robert Hider. 


Teaching Undergraduate Biophysics using Excel. Peter H. Nelson. 


A Novel Approach to Measure Flip-flop of Very Long Chain Saturated Fatty 

Acids (VLCFA) in Model Membranes. Biju K. Pillai, Ravi Jasuja, 

James A. Hamilton. 


Cyclodextrins Deliver FA to Membranes Rapidly while Maintaining a Low 

Concentration of Unbound FA in Water. Kellen Brunaldi, 

James A. Hamilton. 


Permeability of Model Stratum Corneum Lipid Membrane Measured Using 

Quartz Crystal Microbalance. Daeyeon Lee, Eugene Pashkovski, 

David Weitz. 


Roles Of The Membrane Protein CD36 In Fatty Acid Transport And 

Metabolism. Su Xu, James A. Hamilton. 


Analytical Description Of The Diffusion Coefficient And Current Of A Single 

Particle On A Two-dimensional Corral Model. Hernan L. Martinez. 


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Phase Transitions in Single Nano-Vesicles. Poul M. Bendix, Peter P. Wibroe, 

Dimitrios Stamou. 


Intracellular Water Lifetime Depends on Cellular Energetic State. 

Yajie Zhang, Marie Poirer-Quinot, Charles Springer, James Balschi. 


Interaction Of Enrofloxacin With Model Membrane Systems. Implications In 

The Permeation Pathways, Revealed By Fluorescence And Conductance 

Studies. Paula Gameiro, Isabel Sousa, Tivadar Match, Mathias Winterhalter. 


The Porin passport control - Conductance measurements and biological 

relevance. Mahendran R. Kozhinjampara, Tivadar Mach, 

Andrey N. Bessonov, Helge Weingart, Chloe E. James, Jean-Marie Pages, 

Eric Hajjar, Amit Kumar, Matteo Ceccarelli, Mathias Winterhalter. 


Detecting Conformational Changes In The Bacterial Glutamate Transporter 

Homolog GltPh Using EPR Spectroscopy. Paul Focke, 

Pierre Moenne-Loccoz, Peter Larsson. 


Uncovering an Analytical Description of the Transmembrane Voltage 

Bistability at Low Extracellular Potassium Concentrations. Jill Gallaher, 

Martin Bier, Jan Siegenbeek van Heukelom. 

Membrane Dynamics & Bilayer Probes I 

(Boards #B648–#B667) 


Solid-State 2H NMR Spectroscopy Reveals Micromechanics of Raft-Like 

Ternary Lipid Membranes Containing Sphingomyelin and Cholesterol. 

Tim Bartels, Ravi S. Lankalapalli, Robert Bittmann, Michael F. Brown, 

Klaus Beyer. 


Implementation of Two Photon Excitation Fluorescence Microscopy 

Techniques in Langmuir Films. Jonathan Brewer, 

Jorge Bernardino de la Serna Bernardino de la Serna, Luis Bagatolli. 


Three-dimensional Dynamic Structure Of Phospholipid Bilayers Saturated 

With Cholesterol. Marija Raguz, Justyna Widomska, Witold K. Subczynski. 


Comparative Characterization of Lateral Organization and Packing Properties 

of Lipids in Pulmonary Surfactant Membranes and Interfacial Films. 

M. Victoria Picardi, Antonio Cruz, Guillermo Orellana, Jesús Pérez-Gil. 


Nystatin Action On POPC/sterol Membranes Along Its Phase Diagram. 

Javier González-Damián, Iván Ortega-Blake. 


Changes in Membrane Fluidity of Blood Platelets in Myeloid Neoplasm. 

Eugenia Kovacs, Emanuela Cicarma, Tiberiu Corhan, Ana Maria Vladareanu, 

Horia Bumbea, Tudor Savopol. 


NSAIDs Alter Lipid Bilayer Mechanical Properties. Subhi J. Al’Aref, 

Olaf S. Andersen, Roger E. Koeppe II. 


Plasma Membrane Area Increases With Spread Area By Exocytosis Of GPI 

Anchored Protein Compartment. Nils C. Gauthier. 


Diffusion-Matched and Spectrally-Discrete Lipophilic Probes for Neuronal 

Tracing*. Maria Hansen, Jeff Tonniges, Jeremy Duncan, Matthew Bassett, 

Bernd Fritzsch, Brian Gray, Michael Nichols. 


Liposome Steady-state Anisotropy Of E.coli Total Lipid Extracts: A Tool To 

Better Understand Antibiotic Translocation In A Bacterial Environment. 

Jean-Philippe Borges, Carla Queiroz, Marcos Lovelle, Paula Gameiro. 


Laurdan GP Fluctuations In Membranes Of Intact Erythrocytes. 

Susana A. Sanchez, Enrico Gratton. 



Mechanical Pull On A Guest Molecule By A Photoresponsive Lipid Bilayer. 

Jens A. Lundbaek, Peter Tidemand-Lichtenberg, Claus H. Nielsen, Johanna 

M. Kuiper, Jan B. Engberts, Bert Poolman, Salim Abdali. 


Study Of The Drug/lipid Interactions Between Cephalosporin Antibiotics And 

Liposomes By Complementary Techniques. Marcos Lovelle, 

Jean Philippe Borges, Paula Gameiro. 


Inversion of Lipid Bilayer Surface Charge by Trivalent Cations: Probing with 

Single-channel Conductance and Kinetics. Philip A. Gurnev, Brian A. Todd, 

Sergey M. Bezrukov. 


Breakdown of Charged Lipid Asymmetry as a Result of Lipidic Pore 

Formation. Gulcin Pekkurnaz, Konstantine Pavlov, Vadim Frolov, 

Paul S. Blank, Joshua Zimmerberg. 


Percolation Thresholds for Diffusing Particles of Nonzero Radius: Circular 

Obstacles in the Two-dimensional Continuum. Michael J. Saxton. 


Effects Of Hydration On The Dynamics Of Water In Lipid Bilayer Systems: A 

Molecular Dynamics Study. Eric Pinnick, Feng Wang, 

Shyamsunder Erramilli. 


Photophysical Properties of Novel Ruthenium Metal-Ligand Complexes incorporated 

in Lipid Membrane Bilayers. Ayesha Sharmin, Reuben C. Darlington, 

Edward Rosenberg, J.B. Alexander Ross. 


Evaluating Gramicidin A Channel Backbone Dynamics by Molecular 

Dynamics and Nuclear Magnetic Resonance. Helgi I. Ingolfsson, 

Vitaly V. Vostrikov, Hong Gu, Roger E. Koeppe, II, James F. Hinton, 

Benoit Roux, Toby W. Allen, Olaf S. Andersen. 


Assessment of Merocyanine Subpopulations in DPPC Vesicles using Ansitropy 

and Lifetime Measurements. Hannabeth A. Franchino, Brett C. Johnson, 

Steven K. Neeley, Rajeev B. Tajhya, John D. Bell. 

Membrane Active Peptides I (Boards #B668–#B687) 


High Throughput Methods for Discovering Membrane Active Peptides. 

Ramesh Rathinakumar, Jessica R. Marks, Aram Krauson, William C. Wimley. 


Non-membranolytic, Translocating Peptides Selected From A Peptide Library. 

Jessica R. Marks, William C. Wimley. 


PG-1 Orientation in Lipid Bilayers: Insights from Molecular Dynamics 

Simulations and Calculations of Potentials of Mean Force as a Function of Its 

Tilt Angle. Huan Rui, Jinhyuk Lee, Wonpil Im. 


Structure And Dynamics Of Phospholamban In The Context Of SERCA. 

Maryam Sayadi, Michael Feig. 


Antimicrobial Lipopeptides In Anionic And Zwitterionic Membranes 

Investigated By Molecules Dynamics Simulations. 

Alan Grossfield, Julie Hwang, Michael C. Pitman. 


Learning From A Bacillus How To Kill Fungi. Hiren Patel, Heiko Heerklotz. 


Short Membrane Active (Lipo)-peptides - Interplay Of Domain Formation, 

Membrane Curvature Stress And Cellular Leakage. Dagmar Zweytick, 

Guenter Deutsch, Sabine Tumer, Mateja Zorko, Roman Jerala, 

Sylvie Blondelle, Daniel Monreal, Guillermo Martinez de Tejada, Karl Lohner. 


Free Energies of Molecular Bound States in Lipid Bilayers: Lethal 

Concentrations of Antimicrobial Peptides. Huey W. Huang, Ming-Tao Lee. 


Biophysical Parameters Involved in Bacteria Resistance to Antimicrobial 

Peptides. Adi Peleg, Yosef Rosenfeld, Yechiel Shai. 

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Antimicrobial Peptide C18G binds to Lipid Bilayers in a Lipid Composition 

Dependent Manner. Emmanuel Yawson, Jeffrey Foster, Gregory A. Caputo. 


Determination Of The Mechanism Of Action Of Peptides With Antimicrobial 

Potential By P And H Solid-state NMR. Mathieu Noël, 

Aurélien Lorin, Marie-Éve Provencher, Michéle Auger, Normand Voyer. 


Biophysical Characterization And Membrane Interactions Of Peptides With 

Antimicrobial Potential. Aurélien Lorin, Mathieu Noël, 

Marie-Ève Provencher, Mariza Gattuso, François Malouin, Normand Voyer, 

Michèle Auger. 


Can Peptide-Lipid Interactions Predict Bactericidal and Hemolytic Activity in 

Antimicrobial Peptides? Jing He, Michelle Pate, Janet Hammer, Jack Blazyk. 


Molecular Mechanism of pEM-2 Activity. Amy Won, Anatoli Ianoul. 


Deamidation Weakens Membrane Binding Properties of Antimicrobial Peptide 

Anoplin. Amy Won, Anatoli Ianoul. 


The Activity of the Amphipathic Peptide delta-Lysin Correlates with 

Phospholipid Acyl Chain Structure and Bilayer Elastic Properties. 

Antje Pokorny, Erin M. Kilelee, Diana Wu, Paulo Almeida. 


Magainin 2 Revisited: a Test of the Quantitative Model for All-or-None 

Permeabilization of Phospholipid Vesicles. Paulo F. Almeida, 

Sonia M. Gregory, Antje Pokorny. 


Influence Of The Bilayer Composition On The Membrane-Disruption Effect 

Of Polybia-MP1, A Mastoparan Peptide With Antimicrobial And Leukemic 

Cell Selectivity. Marcia Perez dos Santos Cabrera, Manoel Arcisio-Miranda, 

Renata Gorjão, Natalia Bueno Leite, Bibiana Monson de Souza, 

Mario Sergio Palma, Rui Cury, João Ruggiero Neto, Joaquim Procopio. 


Effect of Antimicrobial Peptides from Australian Tree Frogs on Anionic 

Phospholipid Membranes. Frances Separovic, John D. Gehman, 

Tzong-Hsien Lee, John H. Bowie, Marie-Isabel Aguilar. 


The Alignment of Membrane-Active Peptides Depends on the Lipid Phase 

State as Viewed by solid state 19F-NMR. Sergii Afonin, Stephan L. Grage, 

Marco Ieronimo, Daniel Maisch, Parvesh Wadhwani, Pavel K. Mykhailiuk, 

Jesus Salgado, Igor V. Komarov, Anne S. Ulrich. 

Membrane Active Peptides II (Boards #B688–#B702) 


Molecular Determinants of effective Pore Formation. Antje Brack, Markus 

Schwiering, Christian Beck, Max Koistinen, Heinz Decker, Nadja Hellmann. 


Polycation Peptides Derived from the Primary Structure of Bacillus thuringiensis 

Cry11Bb Protoxin Permeabilize Aedes aegypti Midgut Mitochondria. 

Victor V. Lemeshko, Gabriela Jaramillo, Sergio Orduz. 


Phosphatidylserine Selective Peptides As Novel Anti-cancer Agents. 

Yasemin Manavbasi, Dagmar Zweytick, Regine Willumeit, Karl Lohner. 


Human Erythrocytes And Mononuclear Leukocytes Are Capable Of 

Concentrating HIV-1 Fusion Inhibitor Peptides In Their Membranes. 

Pedro M. Matos, Miguel A. R. B. Castanho, Nuno C. Santos. 


Membrane Interaction of N-Terminal Peptides of Annexin A1. 

Heiko Weigelt, Olaf Zschörnig. 


Interaction Of Human Islet Amyloid Poly Peptide With Phospholipid 

Membrane Vesicles. Claudia Dannehl, Martin Stöckl, Andreas Herrmann, 

Olaf Zschörnig. 


Single Particle Analysis of Liposome Leakage Induced by Islet Amyloid 

Polypeptide. Nicholas B. Last, Elizabeth Rhoades, Andrew D. Miranker. 

38 


Amyloid Oligomers Alter The Conductance Of The Gramicidin Channel. 

Yuri V. Sokolov, Saskia C. Milton, Charles G. Glabe, James E. Hall. 


The Insulin-sensitizers Troglitazone And Rosiglitazone Alter Lipid Bilayer 

Properties. Radda Rusinova, Roger E. Koeppe II, Olaf S. Andersen. 


The Antimicrobial Peptide Gramicidin S Permeabilizes Phospholipid Bilayer 

Membranes Without Forming Discrete Ion Channels. 

Md. Ashrafuzzaman, Olaf S. Andersen, Ronald N. McElhaney. 


The Superstructure of an Antimicrobial Peptide, Alamethicin, in Lipid 

Membranes. Jianjun Pan, Stephanie Tristram-Nagle, John F. Nagle. 


Characterization of the Dynamic Structural Changes of Melittin - Lipid Bilayer 

Interactions. Usha Devi, Mark Gostock, Jonathan F. Popplewell, 

Marcus J. Swann. 


Experiments Meet Hydrophobic Mismatch: A Re-evaluation Of The 

Orientation Of Model Transmembrane Peptides From Solid-State NMR. 

Santi Esteban-Martin, Erik Strandberg, Gustavo Fuertes, Anne S Ulrich, 

Jesus Salgado. 


The Structural Plasticity Of Lung Surfactant Peptide KL4 In Lipid 

Membranes. Joanna R. Long, Anil K. Mehta, Yilin Meng, Adrian Roitberg, 

Vijay Antharam, Omjoy Ganesh, Suzanne Farver. 


Structure Of Complexes Of Helix-5 From Bax With Lipid Membranes. 

Gustavo Fuertes, Joshua Manor, Santi Esteban-Martín, Isaiah T. Arkin, Jesús 

Salgado. 

Membrane Physical Chemistry I (Boards #B703–#B732) 


Lateral Stress Profiles In Lipid Monolayers. Svetlana Baoukina, 

Siewert J. Marrink, D. Peter Tieleman. 


Entropy Driven Like Charched Condensation. Uri Raviv. 


Free Energy and Conformation of Hydrocarbons in Lipid Bilayers. 

Eoin P. Coll, D. Peter Tieleman. 


Monte Carlo Simulations of Sterol Superlattice Mosaics in Bilayers Yield 

Simultaneous Agreement with Concentration and Chemical Potential Data. 

Carl S. Helrich, Rebecca K. Friesen, Kathy A. Steiner, Erwin Sucipto. 


The Temperature Dependence And Quantized Nature Of The Lipid 

Membrane Permeability. Andreas Blicher, Katarzyna Wodzinska, 

Thomas Heimburg. 


Headgroup and Interfacial Hydration in Some Headgroup-Modified 

Analogues of Dimyristoylphosphatidylethanolamine: A DSC and FTIR 

Spectroscopic Study. Ruthven N. Lewis, Maria Frias, John R. Silvius, 

Ronald N. McElhaney. 


Giant vesicles under oxidative stress. Karin A. Riske, Tatiane Sudbrack, 

Nathaly L. Archilha, Adjaci U. Fernandes, André P. Schroder, 

Carlos M. Marques, Maurício S. Baptista, Rosangela Itri. 


Miscibility Phase Behavior Of GUV Membranes Containing Ternary Mixtures 

Of PS Lipids, PC Lipids, And Cholesterol. Jake Ashcraft, Sarah Keller. 


Direct Measurement Of Nonideal Mixing In Lipid Membranes. 

Thomas G. Anderson, Bradley Towey. 


Lipid Domains In Giant Vesicles Composed Of Ternary Lipid Mixtures 

Containing Cholesterol And Their Relationship With Thermodynamic Phases. 

Laura Rodriguez Arriaga, John Ipsen, Alejandra Garcia, Steffen Härtel, 

Francisco Monroy, Luis A. Bagatolli. 


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Bursting Instability of Charged Multicomponent Vesicles Subjected to Electric 

Pulses. Karin A. Riske, Roland L. Knorr, Rumiana Dimova. 


Effects Of Sodium Halide Solutions Of High Concentrations On Bending 

Elasticity Of POPC GUVs. Hélène Bouvrais, Philippe Méléard, 

Tanja Pott, John Hjort Ipsen. 


Cholesterol Perturbs Lipid Bilayers Non-Universally. 

Jianjun Pan, Thalia T. Mills, Stephanie Tristram-Nagle, John F. Nagle. 


The Influence of Sterol Composition on Transbilayer Diffusion Rates. 

Christine M. Staloch, Benjamin R. Hoffmann, Benjamin L. Stottrup. 


Cholesterol Flip-flop And Chemical Potential In A Systematic Set Of Lipid 

Bilayers. W.F. Drew Bennett, Justin L. MacCallum, Marlon J. Hinner, 

Siewert J. Marrink, D. Peter Tieleman. 


The Behavior of Two Oxidized Derivatives of Cholesterol in Model 

Membranes. Evan Mintzer, Grace Charles. 


A Calorimetric and Spectroscopic Comparison of the Effects on Ergosterol and 

Cholesterol on the Thermotropic Phase Behavior and Organization of 

Dipalmitoylphosphatidylcholine Bilayer Membranes. 

David A. Mannock, Ruthven N.A.H. Lewis, Ronald N. McElhaney. 


Schiff Base Formation Between The Cholesterol Oxidation Product 3b-hydroxy-5-oxo-5,6-secocholestan-6-al 

And Amino Phospholipids. 

Ellen J. Wachtel, Diana Bach, Israel R. Miller. 


A Comparison Of Ceramide And Ceramide-1-phosphate Miscibility In 

Phosphatidylcholine Bilayers. Michael R. Morrow, Anne Helle, Joshua Perry, 

Ilpo Vattulainen, Susanne K. Wiedmer, Juha M. Holopainen. 


Sterol Solubility in Vesicles (GUV’s) Containing the Ternary Lipid Mixture 

DPPC:DOPC:Sterol by Quantitative NMR. Mark M. Stevens, 

Aurelia R. Honerkamp-Smith, Sarah L. Keller. 


Modeling The Temperature Dependence of Membrane Solubilization by 

Detergents. Nardin Samuel, Alekos Tsamaloukas, Heiko Heerklotz. 


An Approximate Cooperativity Analysis By Dsc And Uv-vis Phase Of 

Pseudobinary DXPC-DC8,9PC-Cholesterol Dispersions. 

Evelina S B Maranzana, Carlos F. Temprana, 

Silvia del V. Alonso-Romanowski. 


Energetics of Cholesterol Transfer between Lipid Bilayers. 

Zhancheng Zhang, Lanyuan Lu, Max L. Berkowitz. 


Impact Of Ceramide3 On POPC Host Membranes: A Study On Structure 

And Thermodynamics. Raghu Sankar M., S. S. Funari, C. L.P. Oliveira, 

J. S. Pedersen, Beate Klösgen. 


The Effect Of Glycerol On Membrane Solubilization By Nonionic Surfactants. 

Hiren Patel, Alekos Tsamaloukas, Heiko Heerklotz. 


Synthetic and Mycobacterial Trehalose Glycolipids Confer Dehydration 

Resistance to Supported Phospholipid Monolayers. Christopher Harland, 

Zsofia Botyanszki, David Rabuka, Carolyn Bertozzi, Raghuveer Parthasarathy. 


How Small Polar Molecules Protect Membrane Systems Against Osmotic 

Stress. Emma Sparr, Fatima Costa-Balogh, Stéphane Douzan, 

Agnieszka Nowacka, Daniel Topgaard, Håkan Wennerström, 

Lars Wadsö. 


How Bilayer Curvatures Modulate Molecular Reaction Efficiencies In A 

Membrane Junction. Andreas H. Kunding, Dimitrios Stamou. 



Effect of Poloxamer 188 on the Osmotic Response of Cell Membranes. 

Jia-Yu Wang, Jaemin Chin, Jeremy Marks, Ka Yee C. Lee. 


Self-assembly Formation of Multiple Tethered Lipid Bilayers. 

Seyed Tabaei. 

Smooth & Skeletal Muscle Electrophysiology 

(Boards #B733–#B735) 


ATP Regulates Mammalian Neuromuscular Transmission by Dramatically 

Decreasing the Resting Muscle Chloride Conductance via P2Y1. 

Andrew Voss, Julio Vergara. 


Cycloxygenase-2 Inhibitor Celecoxib Is A Potent Activator Of Vascular KCNQ 

K 1 Channels And An Inhibitor Of L-type Ca 21 Channels. 

Lyubov I. Brueggemann, Kenneth L. Byron. 


Basal Ca 21 Entry Controls NFAT Transcriptional Activity, Proliferation And 

Migration Of Human Vascular Smooth Muscle Cells. Alain Coulombe, 

Yassine Sassi, Fabrice Atassi, Lahouaria Hadri, Stephane N. Hatem, 

Roger Hajjar, Anne-Marie Lompre, Larissa Lipskaia. 

Acetylcholine Receptors (Boards #B736–#B757) 


Cellular Basis Of Nicotine-induced nAChr Upregulation. Rahul Srinivasan, 

Rigo Pantoja, Sindhuja Kadambi, Henry A. Lester. 


a-7 Nicotinic Receptor Positive Allosteric Modulators have Varying Kinetic 

Effects on Desensitization and Current Amplitude. Sarita Yeola, Flora Jow, 

Yan Tony Lee, Angela Kramer, Tim Lock, John Dunlop, Ravi Peri, 

Mark R. Bowlby. 


Channel Blocking Properties Of Tetramethylammonium At The Human 

Muscle Acetylcholine Receptor. Remigijus Lape, David Colquhoun, 

Lucia Sivilotti. 


Temperature Dependence And Activation Energy of nAChR Gating. 

Shaweta Gupta, Anthony Auerbach. 


Interaction Between Two Domains in the AChR Gating Reaction. 

David J. Cadugan, Lin Chen, Anthony Auerbach. 


bM2 of The Neuromuscular AChR : Gating, Desensitization and Orientation. 

Snehal V. Jadey, Prasad Purohit, Anthony Auerbach. 


The Unliganded Gating Mechanism Of Nicotinic Acetylcholine Receptors. 

Prasad G. Purohit, Anthony Auerbach. 


Detection and Trapping of Elusive Priming Intermediates Towards Open 

Nicotinic Receptor Channel. Nuriya F. Mukhtasimoova, Won Yong Lee, 

Hai-Long Wang, Steven M. Sine. 


Single Channel Current Through Nicotinic Receptor Produced By Closure Of 

The Binding Site C-loop. Hai-Long Wang, Steven M. Sine. 


Electrical Fingerprinting Reveals Agonist Binding Sites Required for Activation 

of Homo-pentameric Cys-loop Receptors. Cecilia B. Bouzat, Diego Rayes, 

Maria Jose De Rosa, Steven M. Sine. 


Photoaffinity Labeling the Agonist Binding Sites of nAChRs with 

[H]Epibatidine. Shouryadeep Srivastava, Ayman K. Hamouda, 

Mitesh Sanghvi, Akash Pandhare, Phaneendra K. Duddempudi, Sarah Hiyari, 

David C. Chiara, Jonathan B. Cohen, Michael P. Blanton. 


Hyperfine Splitting Trends in the EPR Spectra of M2d in Aligned 

Phospholipid Bilayers. Nidhi Subbaraman, Stuart M. Grosser, 

Justin P. Newstadt, Johnson J. Inbaraj, Daniel J. Mayo, Gary A. Lorigan. 

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Examining the Structure of the Neuronal a4b2 nAChR Transmembrane 

Domain by Photoaffinity Labeling. Ayman K. Hamouda, S. Shaukat Husain, 

Michael P. Blanton, Jonathan B. Cohen. 


Regulation Of The Acetylcholine Receptor Function By Thyroid Hormones. 

Yomarie Rivera, Gisselle Lopez, Lydia Miranda, Martita Marcano, 

Yanira Marcano, Solalba Bueno, Jenise Segarra, Amelia Rivera, Legier V. Rojas. 


Role of Membrane Cholesterol Levels in the Lateral Diffusion and Function of 

the Novel Slow Channel Congenital Myasthenia Syndrome aC418W AChR 

Mutant. Jessica Oyola-Cintrón, Daniel Caballero-Rivera, Leomar Ballester, 

Karla Vélez-Arroyo, Jomarie García-Matos, Leonardo Martínez, 

Carlos J. Nogueras, Orestes Quesada, José García, Walter I. Silva, 

José A. Lasalde-Dominicci. 


Modulation Of Nicotinic Acetylcholine Receptor Conformational States By 

Free Fatty Acids And Steroids. Silvia S. Antollini, Gaspar Fernandez Nievas, 

Francisco J. Barrantes. 


Embedded Cholesterol in the Nicotinic Acetylcholine Receptor. 

Grace Brannigan, Jerome Henin, Richard Law, Roderic Eckenhoff, 

Michael L. Klein. 


Identification Of Channel-lining Residues In The Prokaryotic Proton-gated 

Cys-loop Receptor Ion Channel From Gloeobacter Violaceus. 

Rishi Parikh, Moez Bali, Myles H. Akabas. 


Oligomeric Size of the M2 Muscarinic Receptor in the Plasma Membrane of 

Live Cells as Determined by Quantitative FRET. Luca F. Pisterzi, 

David B. Jansma, John Georgiou, Michael J. Woodside, 

Judy Tai-Chieh Chou, Stéphane Angers, Valericǎ Raicu, James W. Wells. 


Oligomeric Size of the M2 Muscarinic Receptor in Live Cells as Determined 

from FRET Efficiencies at the Level of Single Pixels. Luca F. Pisterzi, 

Michael R. Stoneman, James W. Wells, Valericǎ Raicu. 


Gating Current Measurements Reveal Ligand-Selective Conformational 

Changes in the M2 Muscarinic Receptor. Ricardo Navarro-Polanco, 

Eloy Moreno-Galindo, Tania Ferrer-Villada, Marcelo Arias, J. Ryan Rigby, 

Jose S nchez-Chapula, Martin Tristani-Firouzi. 


Site-specific Fluorescence Reveals GABA-induced Structural Movements Near 

the Extracellular End of the Pore-lining M2 a-helices of the GABA-A Receptor. 

Cassandra M. Theusch, Meyer B. Jackson, Cynthia Czajkowski. 

Channel Regulation & Modulation 

(Boards #B758–#B787) 


Chronic and Acute n-3 Polyunsaturated Fatty Acid (n-3 PUFA) Treatments 

Have Divergent Effects on Cardiac Ion Channel Function. 

Xulin Xu, Min Jiang, Mark A. Wood, Clive M. Baunmgarten, Gea-Ny Tseng. 


Acute Toxic Effects Of Fatty Acids. Evgenia I. Fedotova, 

Alexey V. Berezhnov, Valery P. Zinchenko, Vladimir V. Dynnik. 


Oxidative Inactivation of the Lipid Phosphatase PTEN as a Novel Mechanism 

of Acquired Long QT Syndrome. Adrienne Dennis, Xiaoping Wan, Lu Wang, 

Eckhard Ficker. 


Can Pharmacological Openers Of M-type Potassium Channels Overcome 

Receptor-mediated Channel Inhibition? John E. Linley, Nikita Gamper. 


Identification of Phosphorylation Sites that Activate Voltage Gated Proton 

Channels in Leukocytes. Boris Musset, Melania Capasso, Vladimir V. Cherny, 

Deri Morgan, Martin J.S. Dyer, Thomas E. DeCoursey. 


Differential Regulation Of The L-type Ca Channels And SERCA Pump By 

Type 3 Phosphodiesterase. Andriy Belevych, Dmitry Terentyev, 

Radmila Terentyeva, Sandor Gyorke. 

40 


IKS Is Activated By Both Ca 21 Dependent And Independent Isoforms Of 

PKC. Jin O-Uchi, Alessandra Matavel, Coeli M.B. Lopes. 


Phosphorylation Of KAT1 C-terminus Modulates K1 Uptake Activity. 

Aiko Sato, Mitsutaka Taniguchi, Hiroshi Miyake, Taishi Umezawa, Kazuo 

Shinozaki, Derek B. Goto, Nobuyuki Uozumi. 


Modulation of the Cardiac Transient Outward Potassium Current by Alpha1- 

Adrenoceptors Requires Caveolae Integrity. Aintzane Alday, Janire Urrutia, 

Monica Gallego, Oscar Casis. 


Human Ether á-go-go Gene Potassium Channels Are Regulated by EGFR 

Tyrosine Kinase. W Wu, C P. Lau, H F. Tse, G R. Li. 


Modeling Of The Adrenergic Response Of The Human IKs Current 

(hKCNQ1/hKCNE1) Stably Expressed In HEK-293 Cells. 

John P. Imredy, Jacob R. Penniman, Spencer J. Dech, Winston D. Irving, 

Joseph J. Salata. 


Loss Of Transient Outward Potassium Current (Ito) Gradient Across The 

Ventricular Wall With Exposure To Elevated Levels Of Glucose. 

Keith W. Dilly, Fernando Santana. 


Effects Of Estrogen On The IKr Channel And Cardiac Repolarization. 

Junko Kurokawa, Masaji Tamagawa, Nobuhiro Harada, Shin-ichiro Honda, 

Haruaki Nakaya, Tetsushi Furukawa. 


Four-and-a-half LIM Protein 2 And Erk1/2 Are Involved In The Regulation 

Of The IKs Current In The Heart. Nathalie Hélix Nielsen, 

Guiscard Seebohm, Kirstine Calloe, Nathalie Strutz-Seebohm, 

Søren-Peter Olesen, Nicole Schmitt. 


L-arginine Decreases L-type Ca21 Current Through Receptor Activation Of 

NO-cGMP Cascade. Enigma Of “Arginine Paradox”. Miroslav N. Nenov, 

Kirill S. Grushin, Oleg Yu Pimenov, Vladimir V. Dynnik, Yurii M. Kokoz. 


Activation of Na 1 -Dependent Potassium Currents by Persistent Sodium 

Currents. Gonzalo Budelli, Travis Hage, Aguan Wei, Patricio Rojas, 

Yuh-Jiin Ivy Jong, Karen O’Malley, Lawrence Salkoff. 


Uptake Of S100A1 And Augmentation Of Cav1 Channel Current And 

Action Potential Duration In Sympathetic Ganglion Neurons. 

Erick O. Hernández-Ochoa, Benjamin L. Prosser, Nathan T. Wright, 

Minerva Contreras, David J. Weber, Martin F. Schneider. 


Direct Interaction Of A Small Molecule Modulator With G551D-CFTR, A 

Cystic Fibrosis Causing Mutation Associated With Severe Disease. 

Stan Pasyk, Canhui Li, Mohabir Ramjeesingh, Christine E. Bear. 


Oscillation of the Membrane Potential of T-cells Forming Immunological 

Synapse. Ferenc Papp, Ágnes Tóth, Orsolya Szilágyi, 

Sándor Damjanovich, Gyorgy Panyi. 


Negative charges in the loop between the A and B box of the T1 domain are 

involved in Kv2.1 and Kv2.1/Kv6.3 channel tetramerization. 

Elke Bocksteins, Alain J. Labro, Evy Mayeur, Dirk J. Snyders. 


Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation. 

Ping Liang, Huayi Wang, Hao Chen, Yuanyuan Cui, Jijie Chai, 

KeWei Wang. 


Divergent PIP2 Sensitivity Confers Differential Muscarinic Agonist Efficacy For 

Suppression Of Kv7 K 1 Channels. Ciria C. Hernandez, Mark S. Shapiro. 


Two Distinct Molecular Mechanisms Underlie pH Sensitivity of the Human 

Potassium Leak Channel K2P2.1. Asi Cohen, Yuval Ben-Abu, 

Noam Zilberberg. 



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How Do Mutations in the L0-linker of ABCC8 Produce Neonatal Diabetes? 

Andrey P. Babenko. 


Comparison between the Functions of TRPP and Other Structurally-related 

Channels and their Links to Membrane Trafficking. 

Peter M. Vassilev, Philipp V. Fuchs, Marie Kanazirska, Liping Chen. 


Binding of Syntaxin 1A to the C-terminus of hERG Channels Affects Channel 

Trafficking and Inactivation. Anton Mihic, Xiaodong Gao, Alvin Shrier, 

Herbert Gaisano, Robert Tsushima. 


Rapidly Inducible Protein Modification Using Rapamycin-mediated 

Complementation Of Tobacco Etch Virus (TEV) Protease. 

Stephen R. Ikeda, Damian J. Williams, Henry L. Puhl. 


Resolving the Structural-Functional Interaction Between HIV-1 Vpu and 

TASK Channels by FLIM/FRET. Kate Hsu, Derek Lin, Tsung-Lin Kuo, 

Huei-Ning Wan, Nai-Wen Chi, Fu-Jen Kao. 


The Positive Effect Of STREX On BK Channels. Owen Jeffries. 


Regulation Of Kcnq2/3 Channels By The Transcriptional Repressor REST In 

Nociception. Lezanne Ooi, Kirstin E. Rose, John E. Linley, Mariusz Mucha, 

Ian C. Wood, Nikita Gamper. 

Voltage-gated K Channels—Permeation (Boards 

#B788–#B809) 


Permeation And Conformational Changes Of The Pore Domain Of The 

Kv1.2 Potassium Channel. Morten Ø. Jensen, David W. Borhani, 

Ron O. Dror, Michael P. Eastwood, Kresten Lindorff-Larsen, Paul Maragakis, 

David E. Shaw. 


Mapping the Binding Site of the Alkoxypsoralen PAP-1 in the Voltage-Gated 

K1 Channel Kv1.3. Pavel I. Zimin, Bojan Garic, Heike Wulff, 

Boris S. Zhorov. 


Modeling of Binding of the Anti-Arrhythmic Compound Vernakalant to 

Kv1.5. Jodene Eldstrom, David Fedida, Hongjian Xu. 


Partnership interactions target Kv1.5 to distinct membrane surface microdomains. 

Núria Villalonga, Ramón Martínez-Mármol, Laura Solé, Rubén 

Vicente, Concepció Soler, Michael M. Tamkun, Antonio Felipe. 


A Novel Screening Tool for Voltage-Gated Ion Channels: Light Induced 

Voltage Clamp. Sonja Kleinlogel, Ulrich Pehl, Maarten Ruitenberg, 

Juergen Rettinger, Bela Kelety, Ernst Bamberg. 


Kv1.7 - Interactions with Protons and a blocking Conotoxin. 

Rocio K. Finol-Urdaneta, Stefan Becker, Heinrich Terlau, Robert J. French. 


Pore Block of KCNQ1 Channels by Zn21 is Modulated by Ancillary Subunits. 

Michael Duffey, Gennadiy Bakis, Khalid Saahah, Rupa Krishnaswamy, 

John Crane. 


Discovery of a Novel Activator of KCNQ1-KCNE1 K1 Channel Complexes. 

Karen Mruk, William R. Kobertz. 


Using Inducible Expression Vector Technology To Create Stable Cell Lines 

Expressing KCNQ2/3, KCNQ4, And KCNQ3/5 Currents Suitable For 

Automated Electrophysiology Platforms. Andrew P. Southan, 

Scott Maidment, Simon Dowler, Matthew Gardener, Anthony Lawrence, 

Omar Aziz, Tristana von Will, Gary Clark. 


The Dipeptidyl-peptidase-like-protein DPP6 Determines the Unitary 

Conductance of Neuronal Kv4.2 Channels. Yuri A. Kaulin, 

Jose A. De Santiago-Castillo, Carmen A. Rocha, Marcela Nadal, 

Bernardo Rudy, Manuel Covarrubias. 



Cardiac Kv4.3 and KCNE2 Are Differentially Regulated by E2 and Have 

Different Sensitivities to Local Heart E2 Concentrations. 

Andrea Ciobotaru, Ligia Toro, Enrico Stefani, Mansoureh Eghbali. 


Vernakalant Blocks Kv4.3 Channels in The Open State Without Significant 

Modulation by KChIP2 Subunits. Shunping Lin, Marc Pourrier, 

John K. Gibson, Donald A. McAfee. 


Characterization of the External Sodium Inhibition of hERG Potassium 

Channels. Jun Guo, Shetuan Zhang. 


Papaverine, A Vasodilator, Blocks The Pore Of The Herg Channel At 

Submicromolar Concentration. Su-Hyun Jo, Hee Kyung Hong, 

Young Jin Kim, Hui Sun Lee, Han Choe. 


Block Of The HERG Mutant D540K By Terfenadine Shows The Opposite 

Dependency On Extracellular Potassium Compared To Block Of WT HERG 

By Terfenadine. Kristofer Richter, Brad Barrows, Stephen Hioe, John Yun, 

Mike Farrell, John Schulze, Alan Miller. 


Isoform-specific Dominant Negative Effects of LQT2 Mutations in hERGa 

and hERGuso Variants. Matthew R. Stump, Qiuming Gong, 

Zhengfeng Zhou. 


Probing the KcsA Permeation Pathway using Barium Block. 

Kene N. Piasta, Christopher Miller. 


Asymmetrical Ligands in the Potassium Channel Cavity. 

Michael J. Lenaeus, Adrian Gross. 


The Water-ion Coupling Ratio for Ion Permeation through the KcsA 

Potassium Channel: Dependencies on Concentration and Species of 

Permeating Ions. Masayuki Iwamoto, Hirofumi Shimizu, Shigetoshi Oiki. 


Light At The End Of The Channel: Photochromic Blockers For Optical 

Control Of Ion Channels In Individual Cells. Alexandre Mourot, 

Matthew R. Banghart, Doris L. Fortin, Dirk Trauner, Richard H. Kramer. 


Exploring Whether a Large Entrance To The Inner Vestibule Of BK Channels 

Is Required For Their Large Conductance. Yanyan Geng, Xiaowei Niu, 

Karl Magleby. 


Ca 21 - and Thromboxane-Dependent Distribution of Functional MaxiK 

Channels in Cultured Astrocytes. Jimmy W. Ou, Yogesh Kumar, 

Abderrahmane Alioua, Enrico Stefani, Ligia Toro. 

Voltage-gated Ca Channels I (Boards #B810–#B828) 


Membrane Voltage More Efficient In Closing Than Opening CaV1.2?. 

Stanislav Beyl, Philipp Kuegler, Michaela Kudrnac, Annette Hohaus, 

Steffen Hering, Eugen Timin. 


Position Specificity of the Glycine Residues in IS6 of the L-type Cav1.2 

Channel. Florian LeCoz, Alexandra Raybaud, Sebastien Wall-Lacelle, 

Yolaine Dodier, Lucie Parent. 


Distinctive Inactivation Profiles of CaV1.2 Channels Encoding Different 

Timothy Syndrome Mutations in Various Alternative Splicing Backgrounds. 

Ivy E. Dick, Sarah A. Park, David T. Yue. 


Silencing of Cav1.2 gene in Rat Neonatal Cardiomyocytes by Lentiviral delivered 

shRNA. Eddy Karnabi, Yongxia Qu, Natalia Grinkina, Raj Wadgaonkar, 

Yunkun Yue, Salvatore Mancarella, Mohamed Boutjdir. 


Construction Of Functional N-type Ca21 Channels (Cav2.2) With Accessible 

External Epitope Tags Suitable For Live Cell Labeling. Henry L. Puhl, 

Van B. Lu, Yu-Jin Won, Damian J. Williams, Stephen R. Ikeda. 

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Role Of Gamma Subunit In The Targeting Of Functional Cardiac L-Type 

Ca 21 Channels. Anna Angelova, Stefania Samojlik, Roman Shirokov. 


Calreticulin Negatively Regulates the Surface Expression of a1D L-Type 

Calcium Channel. Eddy Karnabi, Yongxia Qu, Natalia Grinkina, 

Omar Ramadan, Yunkun Yue, Mohamed Boutjdir. 


Inhibition Of Recycling Endosomes By Brefeldin-A Prevents KLHL1-mediated 

Upregulation Of a1h T-type Currents. Kelly A A. Aromolaran, 

Kellie A. Benzow, Leanne L. Cribbs, Michael D. Koob, 

Erika S. Piedras-Renteria. 


Cardiac L-type Ca Channel as an Oxygen Sensor; Possible Involvement of 

Ca/Calmodulin Binding Domain. Shahrzad Movafagh, Martin Morad. 


Calcium channels regulate myocardial compaction. George A. Porter, Jr. 


Enhancement of the Cav3.1 Channel Activity by PKA in Ventricular Myocytes 

of a1G Transgenic Mice. Yingxin Li, Xiaoying Zhang, Mingxin Tang, 

Hongyu Zhang, Jeffery D. Molkentin, Steven R. Houser, Xiongwen Chen. 


Cardiovascular profile of newly developed Diltiazem analogs. 

Maria Paola Ugenti, Ilona Bodi, Sheryl Elizabeth Koch, Roberta Budriesi, 

Pierfranco Ioan, Roger Hullin, Alberto Chiarini, Arnold Schwartz. 


Charge-dependent And Isoform-specific Interactions Between ProTxii And 

T-type Calcium Channels. Gabrielle B. Edgerton, Emily Hall, 

Kenneth M. Blumenthal, Dorothy A. Hanck. 


Modeling L-type Calcium Channel with Dihydropyridines. 

Denis B. Tikhonov, Boris S. Zhorov. 


Reinterpretation of SCAM Data in View of Kv1.2-based Models of MTSET- 

Substituted CaV2.1 Channels. Iva Bruhova, Boris S. Zhorov. 


Modeling L-type Calcium Channel with Phenylalkylamines. 

Ricky C.K. Cheng, Denis B. Tikhonov, Boris S. Zhorov. 


Effect Of CaVb Subunits On Structural Organization Of CaV1.2 Calcium 

Channels As Revealed By Three-color Fret Microscopy. Evgeny Kobrinsky, 

Parwiz Abrahimi, Sam Thomas, JoBeth Harry, Chirag Patel, QiZong Lao, 

Nikolai Soldatov. 


Quantification Of L-type Ca Current Inactivation Mechanisms In Trout 

Ventricular Myocytes. Laurent Salle, Caroline Cros, Daniel E. Warren, 

Holly A. Shiels, Fabien Brette. 


Egg Coat Proteins Activate Ca 21 Entry into Mouse Sperm via CATSPER 

Channels. Jingsheng Xia, Dejian Ren. 

42 

Voltage-gated Ca Channels II (Boards #B829–#B848) 


A Simple Link Between Gating And Pore Occupancy Can Describe Complex 

Ion-Dependent Kinetics Of Ca21 Channels. Roman Shirokov, 

Anna Angelova, Alexandra Uliyanova. 


Kinetic Modeling of CaV3.1. Katie C. Bittner, Lorin Milescu, 

Dorothy A. Hanck. 


Voltage-sensor Pharmacology Of Voltage-activated Calcium Channels (cav). 

Mirela Milescu, Kenton J. Swartz. 


Independent Contributions Of Segments IS6 And IIS6 To Activation Gating 

Of CaV1.2. Michaela Kudrnac, Stanislav Beyl, Annette Hohaus, Anna Stary, 

Thomas Peterbauer, Eugen Timin, Steffen Hering. 


Role of S4 segments in Cav1 and Cav3 channels: gating and current density. 

Juan F. Higueldo-Garcia, Jonatan Barrera-Chimal, Juan C. Gomora. 


Depolarization-induced Potentiation Of Cav1.1 Does Not Require The Distal 

C-terminus. Joshua D. Ohrtman, Kurt G. Beam. 


Chimera of CaV1.2 and CaV3.1 alpha1 Subunits Suggests Role of the 

C-terminal Tail in Cytosolic Mg21 Actions on CaV1.2 Gating. 

Min Wang, Yoganand Yadari, Joshua R. Berlin. 


CaV1.4 C-tail Segment (ICDI) Inhibits CaV Channel Inactivation by 

Competing with Calmodulin–Resolution by Holochannels and Calmodulin 

FRET Sensors. Xiaodong Liu, Philemon S. Yang, Vincent Wu, Wanjun Yang, 

David T. Yue. 


Structure-function Relationship of N-terminal Deletion Mutants of Cardiac Ltype 

Calcium Channel b1-subunits. Wanchana Jangsangthong, 

Elza Kuzmenkina, Ismail F. Y. Khan, Roger Hullin, Stefan Herzig. 


Modulation Of Calcium Currents By Acidic Domains Of Calcium Channel 

Subunits: A Novel Feedback Mechanism? Vicenta Salvador-Recatala, 

Robert M. Greenberg. 


Role Of Calmodulin On The Binding Of Alpha Actinin And C-terminus Of 

CaV1.2 Ca 21 Channel. Zulfiqar A. Malik, Duane D. Hall, Madeline Shea, 

Johannes W. Hell. 


Functional Properties Of The CaV1.2 Calcium Channel Activated By 

Calmodulin In The Absence Of a2d Subunits. QiZong Lao, 

Arippa Ravindran, Evgeny Kobrinsky, Nikolai Soldatov. 


Inhibition of L-type Ca 21 Channel Window Current By Steroid Hormones in 

Coronary Artery Smooth Muscle Cells. Rikuo Ochi, Sachin A. Gupte. 


Corticotropin-releasing Factor Regulates Somatodendritic Dopamine Release 

By Inhibiting Voltage-dependent Ca 1 Channels. Yonjung Kim, 

Myoung Kyu Park, Sungkwon Chung. 


Rab11b GTPase Is Expressed In Ventricular Myocardium And Regulates 

Trafficking Of L-type Ca21 Channels. Jabe M. Best, Jason D. Foell, 

Jing Wang, Ravi C. Balijepalli, Timothy J. Kamp. 


Methyl-beta-cyclodextrin Attenuates CaV2.3 Channels Modulation By NK1 

Receptors. Ulises Meza, Yamhilette Licón, Sergio Sánchez-Armass. 


The Monomeric G Proteins AGS1 And Rhes Selectively Influence Gai-dependent 

Signaling To Modulate N-type (Cav2.2) Calcium Channels. 

Ashish Thapliyal, Roger A. Bannister, Christopher Hanks, Brett A. Adams. 


Identifying molecular mechanisms underlying PKC regulation of Cav1.2. 

Lin Yang, Darshan Doshi, John Morrow, Alexander Katchman, 

Sergey Zakharov, Steven O. Marx. 


SRAA POSTER 

Multiple Mechanisms and Determinants Underlie Rem Inhibition of Voltagedependent 

Calcium (CaV) Channels. Tingting Yang, Henry M. Colecraft. 


Differential Modulation Of Cardiac L-type Calcium Currents By GaI2 And 

GaI3. Sara Dizayee, Sonja Kaestner, Olga Felda, Roland Piekorz, 

Janos Meszaros, Jan Matthes, Bernd Nürnberg, Stefan Herzig. 

Voltage-gated K Channels - Gating I 

(Boards #B849–#B870) 


Improved Early Detection of HERG Channel Liability in Lead Optimization 

Programs with Automated Patch-Clamp Technology. Arturo Picones, 

Kendra Kim, Jason Munderloh. 


Mechanism Of Action For The hERG Potassium Channel Activator, PD- 

118057. Matthew D. Perry, Michael C. Sanguinetti. 


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Direct Binding Of Divalent Cations To The S4 Region In Eag Family K 1 

Channels Reveals A Closed Conformation Shared With Kv1 Channels. 

Xiaofei Zhang, Badry Bursulaya, Christian C. Lee, Bihan Chen, 

Timothy Jegla. 


Voltage-dependent Fluorescence Associated with Native-Cysteine Residues in 

hERG channels. Robert R. Fougere, HongJian Xu, Saman Rezazadeh, 

Moni Vaid, David Fedida. 


On the Nature of hERG Inactivation using KcsA, Shaker and Kv1.2 as 

Structural and Functional Models. Julio F. Cordero-Morales, 

Vishwanath Jogini, Anthony Lewis, Valeria Vasquez, Martin Tristani-Firouzi, 

Eduardo Perozo. 


Mapping the hERG Channel Activation Gate Using SCAM. 

Sarah Wynia-Smith, Gail Robertson. 


LQT2 Linked Mutations E444d And P451l In The S1-S2 Linker Lead To 

Biophysical Abnormalities Of Herg Channels. Eric Lin, Brooke Moungey, 

Brian P. Delisle, Craig T. January. 


Transfer Of rolf S3-S4 Linker To hERG Eliminates Activation Gating But 

Spares Inactivation. Aziza El Harchi, Frank S. Choveau, Nicolas Rodriguez, 

Bénédicte Louérat-Oriou, Isabelle Baró, Sophie Demolombe, 

Flavien Charpentier, Gildas Loussouarn. 


KvLQT1’s S3 involvement in LQTS. Matthew E. Loewen, Jodene Eldstrom, 

Amanda M. Degenhardt, Hongjian Xu, David Fedida. 


Dynamic Partnership between KCNQ1 and KCNE Subunits. 

Min Jiang, Xulin Xu, Gea-Ny Tseng. 


Using Disulfide Trapping to Probe KCNQ1/KCNE1 Interactions During the 

IKs Channel Gating. Min Jiang, Xulin Xu, Tseng Gea-Ny. 


Physical Interactions Between The Cytoplasmic Domains Of KCNQ1 And 

KCNE1 Channel Subunits. Renjian Zheng, Keith Thompson, Dana Alessi, 

Edmond Obeng-Gyimah, Thomas V. McDonald. 



Mechanism Of IKr Loss In Mutant T421M-hERG Expressing Rat Ventricular 

Myocytes. Sadguna Y. Balijepalli, David J. Tester, Jing Wang, 

Kassandra E. Holzem, Chen Li Chew, Blake D. Anson, Timothy J. Kamp, 

Michael J. Ackerman, Craig T. January. 


Trafficking-deficient LQT2 Mutations Disrupt Different Steps of hERG 

Channel Transport. Jennifer L. Smith, Daniel C. Bartos, Craig T. January, 

Brian P. Delisle. 


Restoration of Deactivation in N-truncated and LQTS HERG K 1 Channel 

Mutants by a Recombinant N-terminal Region Fragment. 

Ahleah S. Gustina, Elena C. Gianulis, Matthew C. Trudeau. 


Functional Consequences of RNA Editing of the eag Potassium Channel. 

Mary Y. Ryan, Rachel Maloney, Robert A. Reenan, Richard Horn. 


Developing In Silico Descriptions Of Herg Channel Gating. Adam P. Hill, 

Anthony Varghese, Socrates Dokos, Stefan Mann, Jamie I. Vandenberg. 


Simulation of Ion Channel Gating: from Energy Landscapes to Macroscopic 

Currents. Ali Nekouzadeh, Yoram Rudy. 


Molecular Dynamics Simulation of the Kv1.2 Potassium Channel. 

Fatemeh Khalili-Araghi, Vishwanath Jogini, Vladimir Yarov-Yarovoy, 

Emad Tajkhorshid, Benoit Roux, Klaus Schulten. 


Quantum Calculations on Potassium Channel Selectivity and Gating. 

Alisher M. Kariev, Michael E. Green. 


Using Molecular Simulation and Quantum Mechanics tools to answer unsolved 

questions about gating of plant voltage gated potassium channels. 

Wendy Gonzalez, Samuel Morales, Jaime Henriquez, Fernando Danilo 

González-Nilo, Ingo Dréyer. 


Understanding gating transitions within K1 channels using Dynamic 

Importance Sampling. 

Elizabeth Denning, Thomas Woolf. 

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